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The role of CD40 and its ligand in transplant tolerance.

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Call No.	Ph.D. 2004
Author	Jarvinen, Lamis Z.
Title	The role of CD40 and its ligand in transplant tolerance.
Date	2004
Abstract	Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical excitability of neurons is unknown. Semi-quantitative, single-cell RT-PCR and patch clamp recording were combined to correlate the expression of Na v isoform genes with electrical characteristics of Purkinje cells from mice between the ages of postnatal day (PND) 4 to adult. There was an increase in electrical excitability of Purkinje cells between PND 8-10, as defined by significant increases in action potential frequency, Na v density, intrinsic ability to fire action potentials, and the percentage of cells with mature firing patterns. Single-cell RT-PCR analyses revealed that several Na v subunit isoforms were expressed in Purkinje cells, including Na v 1.1, Na v 1.2, and Na v 1.6, Na v β1.1, Na v β1.1A, and Na v β2.1. Both the onset of Na v 1.2 expression and an increase in Na v 1.1 expression at PND 9 correlated with increased electrical excitability in these cells. In transgenic mice precociously expressing Na v 1.2, there was an increase in Na v density in Purkinje cells as well as an indication of compensatory K + channel expression. Purkinje cells in mice expressing a noninactivating mutant form of Na v 1.2 had elevated levels of persistent Na + current and electrical excitability, concomitant with altered dendritic morphology. Taken together, these findings suggest that multiple Na v isoforms and multiple components of Na + current play a role in the electrical activity, and ultimately dendritic development of cerebellar Purkinje cells.
Description	ix, 212 leaves : ill. (some col.) 28 cm.
Format	application/pdf
Advisor	Robert Maue.
Subject	CD antigens. T cells -- Receptors. Receptor-ligand complexes. Transplantation immunology. Immunological tolerance -- Molecular aspects. Antigens
College	Dartmouth Medical School -- Department of Immunology.
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Copyright	All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means without permission in writing from the author.
DOI	http://dx.doi.org/10.1349/ddlp.53

Title	Page 1
Format	application/pdf
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Full Text	• c Dr. Carol Folt The Role of CD40 and Its Ligand in Transplant Tolerance A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Microbiology and Immunology by Lamis Z. Jarvinen DARTMOUTH COLLEGE Hanover, New Hampshire January 9, 2004 Examining CO!Jllllittee: Dr. Willi9J1l...E.. @. Rfgby (Chair) Dr. Randolph J. Noelle o. Dr. Christopher M. Burns Dr. cYnn Puddington Dean of Graduate Studies

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The role of CD40 and its ligand in transplant tolerance.

The role of CD40 and its ligand in transplant tolerance.