A new synthetic approach to both pyrrolo[2,3- b]indoles and pyrrolo[3,4- b]indoles by the reaction of 3-nitro-1-(substituted)indoles with functionalized isocyanides is presented. The reaction between 3-nitro-1-(phenylsulfonyl)indole (185) and ethyl...
The lateral hypothalamus is a brain region involved in the regulation of feeding, glucose homeostasis, sleep/wake cycle, and autonomic nervous system (ANS). Melanin concentrating hormone (MCH) containing neurons, located in the lateral...
This research has established feasibility of surface temperature characterization using ruby fluorescence. Study was performed in pin-on-disk geometry, with balls made of different plastics sliding against the sapphire disk. Fluorescence signal was...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...
B cells -- Tumors. ; Cancer -- Immunotherapy. ; T cells. ; CD antigens.
The indolent B-cell malignancies of lymphoma and myeloma account for a great number of adult cancers in the United States annually. Hi-dose combination chemotherapy, bone marrow transplants and monoclonal antibody therapeutics have improved the...
An interval order is an ordered set whose elements are in correspondence with a collection of intervals in a linearly ordered set, with disjoint intervals ordered by their relative position. The order complex of an ordered set is the simplicial...
Eddy currents (Electric) -- Mathematical models. Electric generators -- Windings. Finite element method.
Magnetic components, such as transformers and inductors, are essential parts of most power electronics circuits. They usually are the largest components in the circuit, and also account for a large portion of the power loss. Reducing the volume of...
Bioinorganic chemistry, a discipline that bridges chemistry and biology, has become increasingly popular as new techniques and analytical methods have emerged to study metals in biological systems. One such technique that has become increasingly...
An organism's long-term survival is critically dependent on its ability to protect itself from pathogenic microbial infections. The first line of defense against such infections is the branch of the immune response referred to as the innate immune...
For a local field K, we study the affine buildings Ξ n and Δ n naturally associated to SL n ( K ) and Sp n ( K ), respectively. Since Sp n ( K ) is a subgroup of SL 2 n ( K ), we investigate properties of a natural embedding of Δ n in Ξ 2 n ....
We begin with a result on the refocussing of null geodesics in space-times. We show that all oriented refocussing 2-dimensional Lorentz manifolds are also strongly refocussing. We also introduce a theory of virtual Legendrian knots. We show that...
Partially ordered sets and permutations are combinatorial structures having vast applications in theoretical computer science. In this thesis, we study various computational and algorithmic problems related to these structures. The first chapter of...
Three-dimensional imaging in medicine -- Mathematical models. ; Stereoencephalotomy.
In the past, clinicians skilled at image-guided neurosurgery have relied solely on pre-operative scans for their navigational information. Often in the course of surgery, tissue is purposely retracted/resected or inadvertently moved resulting in a...
Friction severely limits performance in precise positioning systems. This thesis investigates one possible approach to counter friction related performance losses, friction cancellation. In this method a friction observer is used to estimate...
The Dartmouth Stellar Evolution Program, a state of the art stellar evolution code, has been modified and expanded to increase its versatility. The modifications include: the ability to self-consistently model stars with arbitrary chemical...
Lungs -- Cancer -- New Hampshire. Bladder -- Cancer -- New Hampshire. Cancer -- Epidemiology. Cancer -- Environmental aspects -- New Hampshire. Cancer -- Genetic aspects
Complex diseases such as lung cancer are most commonly the result of environmental variables acting on an individual's genetic background. Those environmental variables may be found in the external environment, such as exposures to carcinogenic...
The theory community has worked on Secure Multiparty Computation (SMC) for more than two decades, and has produced many protocols for many settings. One common thread in these works is that the protocols cannot use a Trusted Third Party (TTP), even...
Electric inductors -- Design and construction.;""DC-to-DC converters -- Design and construction."";""Thin film devices -- Design and construction."";""Microfabrication."";""Magnetic films."";""Thin films Multilayered."";""Granular...
Investigations into alternative breast cancer (BC) imaging techniques have become increasingly popular based on the limitations of traditional imaging modalities: X-ray mammography uses ionizing radiation, has limited intrinsic contrast and is...
Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
We present designs, theory and the results of fabrication and testing for a novel parallel microrobotic assembly scheme using stress-engineered MEMS microrobots. The robots are 240-280 μm × 60 μm × 7-20 μm in size, each robot consist of a...
Robots -- Control systems -- Design and construction. Mobile robots. Robots -- Dynamics.
This thesis examines the issues of vehicle and information dynamics in the control of a multi-robot system using a radial-basis potential function controller. Distributed control of multi-robot systems requires each robot to communicate state...
'Orthogonal modular forms are algebraic modular forms arising from lattices in quadratic spaces. In this thesis, we define orthogonal modular forms, establish their basic properties, and then apply them to a case of ternary quadratic spaces to...