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    • Investigation of trans-acting factors in AURE-mediated mRNA turnover.

    • Investigation of trans-acting factors in AURE-mediated mRNA turnover.
    • Messenger RNA -- Metabolism. ; Trans-Activation (Genetics). ; RNA-protein interactions. ; Adenosine. ; Uridine. ; Lactate dehydrogenase. ; Genetic regulation. ; RNA-Binding Proteins. ; Protein processings Post-transcriptional. ; Hippel-Lindau...
    • Post-transcriptional pathways provide a major means of regulating eukaryotic gene expression. Reiterations of the AU-rich element (AURE) located within the 3' UTR of many labile cytokine and proto-oncogene mRNA serve as signals for rapid...
    • The role of p38 MAP kinase in the regulation of mRNA stability.

    • The role of p38 MAP kinase in the regulation of mRNA stability.
    • Messenger RNA -- Metabolism. ; Mitogens. ; Thalidomide. ; Glucose -- Physiological transport. ; Mitogen-Activated Protein Kinases. ; MAP Kinase Signaling System. ; Protein processings Post-transcriptional. ; Hippel-Lindau Disease.
    • We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...

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