Quality of life -- Evaluation. ; Health status indicators. ; Psychiatric rating scales. ; Mental illness -- Treatment -- Evaluation. ; Mental illness -- Treatment -- Economic aspects. ; Mental illness -- Treatment -- Social aspects.
Background. It is not clear whether a generic quality-of-life instrument can appropriately represent severe mental illness in an economic evaluation. This problem is particularly salient for resource-allocation decisions where policymakers compare...
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
In this thesis, we study the dynamics of magnetic flows on compact nilmanifolds. Magnetic flows are generalizations of geodesic flows. They model the motion of a particle of unit mass and unit charge in a smooth manifold M in the presence of a...
Spot 14 (S14) is a ~17 KD nuclear protein that functions at the transcriptional level to regulate de novo synthesis of fatty acids in liver, brown and white adipose, and. lactating mammary tissues. Localization of the S14 gene to chromosome 11q13.5...
Sorting very large datasets is a key subroutine in almost any application that is built on top of a large database. Two ways to sort out-of-core data dominate the literature: merging-based algorithms and partitioning-based algorithms. Within these...
Self-reconfiguring (SR) robots are modular systems that can autonomously change shape, or reconfigure , for increased versatility and adaptability in unknown environments. In this thesis, we investigate planning and control for systems of...
We begin with a result on the refocussing of null geodesics in space-times. We show that all oriented refocussing 2-dimensional Lorentz manifolds are also strongly refocussing. We also introduce a theory of virtual Legendrian knots. We show that...
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
We study the bijective combinatorics of reduced words. These are fundamental objects in the study of Coxeter groups. We restrict our focus to reduced words of permutations and signed permutations. Our results can all be situated within the context...
This thesis constitutes the first steps in the author's program to investigate the question of when a homotopy of 2-cocycles Ï‰ = {Ï‰[subscript t]}[subscript tâˆŠ[0,1]] on a locally compact Hausdorff groupoid Æ“ induces an isomorphism of the...
The focus of this thesis is the study of nuclearity and exactness for groupoid crossed product C*-algebras. In particular, we present generalizations of two well-known facts from group dynamical systems and crossed products to the groupoid setting....
Gene set testing has become a critical tool for interpreting the results of high-throughput genomic experiments. Despite the development of robust statistical methods and extensive gene set collections, however, the results from gene set testing...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
In this thesis, we characterize and enumerate the permutations which are realized by the orbits of signed shifts, a family of discrete dynamical systems on words. The permutations, which are called patterns of the signed shifts, are given by the...
In Chapter 2 we look at the distribution of permutation statistics in the context of pattern-avoiding permutations. The first part of this chapter deals with a recursively defined bijection of Robertson [37] between 123- and 132-avoiding...
The Euler '-function and Carmichael -function are extremely important in modern number theory, and much work has been devoted to studying the distribution and arithmetic properties of the values of each function. One interesting unresolved question...
Sex determination in C. elegans leads to the development of sex-specific structures and contributes to the regulation of sexually dimorphic programmed cell death. A search for factors that regulate the sexually dimorphic cell death of the...
Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
While Cherenkov emission was discovered more than eighty years ago, the potential applications of imaging this during radiation therapy have just recently been explored. With approximately half of all cancer patients being treated by radiation at...
Magnetic nanoparticles are promising candidates for use in biomedical applications as remote sensors of biophysical properties, thermal therapy agents, and detectors of specific biomolecules. Many approaches have been used to model magnetic...
In this thesis we study 1=k-geodesics, those closed geodesics that minimize on any subinterval of length L=k, where L is the length of the geodesic. These curves arise as critical points of the uniform energy, a function introduced in Morse theory...
The accelerated expansion of space in the Universe has been known for two decades. However, finding a plausible theory that describes this expansion is more difficult: Taking general relativity for granted requires us to stipulate the existence of...
For ordinary knots in R 3 , there are no degree one Vassiliev invariants. For virtual knots, however, the space of degree one Vassiliev invariants is infinite dimensional. We introduce a sequence of three degree one Vassiliev invariants of virtual...
Identifying the determinants of reproductive success in small-scale societies is critical for understanding how natural selection has shaped human evolution and behavior. The available evidence suggests that status-accruing behaviors such as...
Motivated by quantum mechanics and geometric optics, it is a long-standing problem whether the length spectrum of a compact Riemannian manifold can be recovered from its Laplace spectrum. One route to proving that the length spectrum depends on the...
'Orthogonal modular forms are algebraic modular forms arising from lattices in quadratic spaces. In this thesis, we define orthogonal modular forms, establish their basic properties, and then apply them to a case of ternary quadratic spaces to...
This thesis investigates a notion of Turing reducibility introduced by Winkler [8] that is total on all computably enumerable oracles. Groszek and Weber show in [7] that this is a new notion of reducibility and it is not transitive. They give su...
Partially ordered sets and permutations are combinatorial structures having vast applications in theoretical computer science. In this thesis, we study various computational and algorithmic problems related to these structures. The first chapter of...
In this thesis I present analyses of optical and X-ray data of early-type galaxies in nearby rich clusters as part of the NOAO Fundamental Plane Survey. Spectroscopic parameters, including linestrengths and velocity dispersions are measured for...
The Border Gateway Protocol (BGP) that manages inter-domain routing on the Internet lacks security. Protective measures using public key cryptography introduce complexities and costs. To support authentication and other security functionality in...
Siegel domains. Modular groups. Hecke algebras. Forms
In the 1960s Satake proved the existence of an isomorphism between the local Hecke algebra and the ring of polynomials invariant under the action of the signed permutation group W n (the Weyl group associated to Sp n over a local field)....
Forest ecology -- Northeastern States. ; Forest canopy ecology -- Northeastern States. ; Forest dynamics -- Northeastern States.
In closed-canopy forests, changes in the relative abundance of tree species due to major disturbance or to its absence are thought to be governed principally by differences among component species in the performance of juveniles. However, few...
Geomagnetic micropulsations. ; Magnetosphere. ; Cosmic magnetic fields -- Measurement.
A study of magnetospheric pulsations is presented in three parts. The first consists of a statistical survey using data from the AMPTE/IRM satellite. A number of conclusions are drawn from the study. Evidence is provided that supports the theory...
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Breast -- Cancer -- Diagnosis. ; Near infrared reflectance spectroscopy. ; Image processing -- Digital techniques.
Near-infrared (NIR) light has the potential to be used as a non-invasive means of diagnostic imaging within the human breast. Due to the diffusive nature of light in tissue, computational model-based methods are required for functional imaging...
An interval order is an ordered set whose elements are in correspondence with a collection of intervals in a linearly ordered set, with disjoint intervals ordered by their relative position. The order complex of an ordered set is the simplicial...
Friction severely limits performance in precise positioning systems. This thesis investigates one possible approach to counter friction related performance losses, friction cancellation. In this method a friction observer is used to estimate...
The docking and fusion of cellular membranes plays an essential role in the secretory and endocytic pathways and in organelle inheritance. The homotypic fusion of vacuoles from the yeast Saccharomyces cerevisiae has been used as a model system to...