MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
A fiber can transmit around 25 Tbit/s, but electronic signal processing today is performed at much slower speeds, usually 1-10 Gbit/s. To avoid this "bottleneck" in optical fiber communication systems, all signal processing will have to be done...
Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
A mobile agent is an autonomous program that can migrate under its own control from machine to machine in a heterogeneous network. In other words, the program can suspend its execution at an arbitrary point, transport itself to another machine, and...
A method for the reconstruction of a spectrum of mechanical properties from phase-contrast, MR displacement data is developed and implemented via the finite element method. To overcome the significant computational load associated with...
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
This thesis describes a new synthesis of substituted (3H)-1,2-dithiole-3-thiones (dithiolethiones) from readily available starting materials. Dithiolethiones have a wide variety of industrial and pharmaceutical applications. These include use as...
Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
A novel synthetic route to the synthesis of 9-propyl-10-azacyclododecan-12-olide (1), a natural allomone isolated from the Mexican bean beetle pupa, is presented. The salient features of this synthetic route are a regioselective Beckmann...
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
5,6-Azulyne, the first azulyne to be prepared, has been trapped with furan to give an adduct whose crystal structure reveals marked bond alternation in the azulene pi system. The double bond in the furan moiety is responsible in part for the bond...
Geomagnetic micropulsations. ; Magnetosphere. ; Cosmic magnetic fields -- Measurement.
A study of magnetospheric pulsations is presented in three parts. The first consists of a statistical survey using data from the AMPTE/IRM satellite. A number of conclusions are drawn from the study. Evidence is provided that supports the theory...
The thesis is dedicated to the understanding and characterization of brittle compressive fracture of columnar S2 ice. The work quantifies the strength of fresh-water S2 ice and investigates its characteristic brittle failure modes under biaxial...
The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...
Three-dimensional imaging in medicine -- Mathematical models. ; Stereoencephalotomy.
In the past, clinicians skilled at image-guided neurosurgery have relied solely on pre-operative scans for their navigational information. Often in the course of surgery, tissue is purposely retracted/resected or inadvertently moved resulting in a...
Let K be the function field over a finite field of odd order, and let H be a definite quaternion algebra over K. If Α is an order of level M in H , we define theta series for each ideal I of Α using the reduced norm on H. Using harmonic analysis...
Interaction with aromatic π systems has become recognized as an important mode of stabilization of carbocation intermediates in biological reactions. To gain insight into such carbocation-π interactions, we have undertaken a study of...
Spectral theory is the subfield of differential geometry which provided the solution to Kac''s famous question, "Can you hear the shape of a drum?" That is, can we use the Laplace spectrum of a manifold to draw conclusions about its geometry or...
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Eating disorders are a persistent problem for women on college campuses across the country, and peer education programs are one method that colleges have employed to address these concerns. A previous study found that peer education is actually...
Hypercapnia -- Regulation. ; Carbon dioxide -- Physiological effect. ; Carbon dioxide in the body. ; Brown garden snail -- Respiration. ; Potassium channels.
After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...
RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...