Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
We study the bijective combinatorics of reduced words. These are fundamental objects in the study of Coxeter groups. We restrict our focus to reduced words of permutations and signed permutations. Our results can all be situated within the context...
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
This thesis constitutes the first steps in the author's program to investigate the question of when a homotopy of 2-cocycles Ï‰ = {Ï‰[subscript t]}[subscript tâˆŠ[0,1]] on a locally compact Hausdorff groupoid Æ“ induces an isomorphism of the...
The focus of this thesis is the study of nuclearity and exactness for groupoid crossed product C*-algebras. In particular, we present generalizations of two well-known facts from group dynamical systems and crossed products to the groupoid setting....
Gene set testing has become a critical tool for interpreting the results of high-throughput genomic experiments. Despite the development of robust statistical methods and extensive gene set collections, however, the results from gene set testing...
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
In the nervous system, neuronal communication relies critically on the function of membrane ion channels. One of these is the voltage-gated sodium channel (VGSC), which is essential for the generation and propagation of action potentials in...
G protein coupled receptors (GPCRs) make up somewhere between 30-50% of all current drug targets, yet the structural characterization of these receptors has been moderate at best. Until recently, structural data were almost nonexistent and...
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
Ice mechanics. Compressibility. Fracture mechanics. Strains and stresses. Brittleness.
This work describes the effect of triaxial compressive confinement on the strength of columnar S2 ice loaded under conditions leading to brittle failure. Cubes of columnar S2 ice were tested at -10 Â°C under triaxial (proportional) loading where...
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...