The brain is a vastly interconnected information processing network. In humans, this network supports the rich mental space at the root of the imagination and enables many flexible cognitive abilities such as scientific and artistic creativity. How...
The transmissible spongiform encephalopathies (TSEs), also known as the prion diseases, are a unique group of fatal neurodegenerative diseases affecting humans and other mammals that have infectious, inherited and sporadic etiologies. A central...
The proliferation of mobile devices and other consumer products has greatly expanded the market for CMOS image sensors. This in turn has promoted a trend of continued improvement in image sensor performance, as companies seek to gain an advantage...
Across mammalian species, adolescence is characterized by a unique combination of cognitive, behavioral and neurobiological changes. Behavioral tendencies observed during this period promote a variety of flexible interactions with the surrounding...
Cosmic acceleration could be an effect of a ""dark energy"" fluid pervading the Universe. It could also be an indication that general relativity is not the correct theory of gravity at cosmological length scales. Unfortunately, observations of the...
Wireless communication systems. Computer networks. Routers (Computer networks).
A mesh network is a network of wireless routers that employ multi-hop routing and can be used to provide network access for mobile clients. Mobile mesh networks can be deployed rapidly to provide an alternate communication infrastructure for...
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
A metric structure on a set gives a concept of distance between any two elements of that set, and it induces a topology. In this thesis, we provide several ways to put a metric structure on the collection of CW complexes. We accomplish this by...
Proteins -- Structure -- Mathematical models. Recombinant proteins -- Mathematical models. Mathematical optimization -- Data processing. Dynamic programming. Protein engineering.
Site-directed protein recombination produces improved and novel protein variants by recombining sequence fragments from parent proteins. The resulting hybrids accumulate multiple mutations that have been evolutionarily accepted together. Subsequent...
Temperature has powerful effects on all scales of biological organization from biochemical reactions to ecosystem processes. Despite the well-appreciated influence and thorough understanding of the physiological and population consequences of...
In Chapter 2 we look at the distribution of permutation statistics in the context of pattern-avoiding permutations. The first part of this chapter deals with a recursively defined bijection of Robertson [37] between 123- and 132-avoiding...
The Euler '-function and Carmichael -function are extremely important in modern number theory, and much work has been devoted to studying the distribution and arithmetic properties of the values of each function. One interesting unresolved question...
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
I investigated the effects of two contemporary disturbances to soil systems: forest clearing in the northeastern U.S. and climate-driven plant succession in the Arctic. To test the effects of clear-cutting forests on mineral soil carbon (C)...
This thesis centers around a generalization of the classical discrete Fourier transform. We first present a general diagrammatic approach to the construction of efficient algorithms for computing the Fourier transform of a function on a finite...
Morbidity and complexity involved in lymph node staging via surgical resection and biopsy could ideally be overcome using node assay techniques that are non-invasive. Visible blue dyes, fluorophores and radio-tracers are often used to locate the...
Aneuploidy is the leading cause of pregnancy loss and birth defects in humans. At least 5% of all recognized pregnancies are aneuploid. Maternal meiosis is especially error-prone and the rate of chromosome missegregation increases exponentially...
Hedgehog (HH) proteins play an important and evolutionary conserved patterning role in metazoan development. Aside from this physiological role, pathologically HH proteins are implicated in human developmental disorders and post-developmental...
Measurement of the ionospheric thermal particle population bridges the two different communities of ground-based radar and space-based rocket studies, which have the common goal of characterizing heavy ion transport in the cusp/cleft region. We...
We present designs, theory and the results of fabrication and testing for a novel parallel microrobotic assembly scheme using stress-engineered MEMS microrobots. The robots are 240-280 μm × 60 μm × 7-20 μm in size, each robot consist of a...
American beech -- Ecology -- North America -- Mathematical models. Beech bark disease -- Mathematical models. Fungal populations -- Mathematical models. Nonindigenous pests -- Environmental aspects -- Mathematical models.
When a nonnative insect or pathogen becomes established in a forest, outcomes for host trees can range from local or minor effects to regional extirpation. Elevated host mortality is often accompanied by compensatory recruitment by co-occurring...
Oligomers -- Structure -- Mathematical models. Nuclear magnetic resonance spectroscopy.
Medical Term: Nuclear Magnetic Resonance, Biomolecular.
Protein complexes play vital roles in the fundamental processes of life. In particular, homo-oligomers are involved in cell signaling, regulation, and transport. To make detailed studies of these symmetric proteins, they need to be discovered, and...
Many microbes thrive in conditions that would be detrimental to human life. These microorganisms have been dubbed extremophiles. Of these, members of a subcategory, termed thermophiles, grow optimally above 45°C. Thermoanaerobacterium...
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...