Many alkaloids of biological importance have the 11H-pyrido (4,3,2-mn) acridine ring structure such as cystodytin and amphimedine. It would be desirable to find an effective way to synthesize a wide variety of these compounds using a single...
Nucleotide sequence -- Data processing. Linkage (Genetics) -- Data processing. Computer algorithms. Human population genetics. Medical Term Base Pairing -- genetics. Base Sequence -- genetics. Genome wide association studies.
This thesis investigates techniques for the discovery and use of phase information in genetic studies. ""Phase"" refers to the precise assignment of the members of a different base pairs at the same genomic locus to two possible candidate...
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
This thesis centers around a generalization of the classical discrete Fourier transform. We first present a general diagrammatic approach to the construction of efficient algorithms for computing the Fourier transform of a function on a finite...
A double-acceleration stage linear time of flight mass spectrometer (TOF MS) with Nd/YAG laser ablation cluster source was designed and constructed for cluster production, study and deposition. Cumulenic polycarbons SC n S ( n = 2-27) were...
Polynomials. Finite fields (Algebra). Algebraic functions. Number theory.
The ring of univariate polynomials over a finite field shares many foundational arithmetic properties with the ring of rational integers. This similarity makes it possible for many problems in elementary number theory to be translated 'through the...
The Greenland Ice Sheet (GrIS) is responding sensitively to climate change and its meltwater has the potential to influence global sea level. Recently, large changes in the GrIS have occurred including increased velocities of outlet glaciers and...
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
In this work we investigate the quantum dynamics of three different configurations of nonlinear cavity systems. We begin by carrying out a quantum analysis of a dc superconducting quantum interference device (SQUID) mechanical displacement detector...
Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
For a local field K, we study the affine buildings Ξ n and Δ n naturally associated to SL n ( K ) and Sp n ( K ), respectively. Since Sp n ( K ) is a subgroup of SL 2 n ( K ), we investigate properties of a natural embedding of Δ n in Ξ 2 n ....
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
In the past decade, the use of ordinal patterns in the analysis of time series and dynamical systems has become an important tool. Ordinal patterns (otherwise known as a permutation patterns) are found in time series by taking n data points at...
This thesis presents technologies for the design, fabrication, operation, and control of electrostatic MEMS micro-robots. It describes prototype micro-robots, with dimensions of 60 μm by 250 μm by 10 μm, that are capable of controllable...
Today''s fastest microprocessors, logic chips, and even memory chips employ dynamic logic as the key part to achieving advanced performance. Dynamic logic only retains the correct data state briefly and is far less robust than previous technologies...
Epistasis (Genetics) Bioinformatics -- Methodology. Genetics -- Data processing. Medical Term Computational Biology -- methods.
A goal of human genetics is the prediction of an individual's risk of common human diseases from their genome sequence. Currently genome-wide methods to measure genetic variation across individuals exist, but methods to effectively analyze these...
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
Nanocomposite materials containing both gold and cobalt were synthesized using block copolymers as agents for controlling spatial organization of the nanoparticles. The targeted polymers are polystyrene- block -poly(alkyne-functional)styrene...
Colloidal nanoparticles are particles with sizes ranging from one nanometer to several hundred nanometers, which disperse evenly in a dispersion medium. In aqueous solutions, amphiphilic molecules organize themselves to form such colloidal systems...
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
The eukaryotic cilium (also called flagellum) is a complex, microtubule-based organelle that is found on many different cell types. It produces movement by the precise activation of dyneins that are located along the length and the circumference of...
Glutamic acid -- Receptors. Ion channels -- Molecular aspects. Ligand binding (Biochemistry). Biological transport -- Regulation. Receptors.
AMPA receptors (AMPA-Rs) are glutamate-gated ion channels that mediate the majority of excitatory synaptic transmission in the brain. AMPA-Rs are generally found in vivo as hetero-tetramers made up of a combination of the GluR1-GluR4 subunits....
One of the important challenges facing image-guided neurosurgery is the fact that the brain deforms significantly over the course of an operation during open-cranial procedures. This results in a loss of registration between the brain and the...
We present a number of findings concerning groupoid dynamical systems and groupoid crossed products. The primary result is an identification of the spectrum of the groupoid crossed product when the groupoid has continuously varying abelian...
Plants -- Effect of iron on. Iron -- Metabolism -- Molecular aspects. Chloroplasts. Plant mitochondria. Homeostasis. Plant enzymes. Reduction (Chemistry). Iron chelates.