The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Chlorinated ethenes are ubiquitous environmental pollutants of public concern due to their potential toxicity and carcinogenicity. Under appropriate conditions anaerobic bacteria mediate the dechlorination of perchloroethylene (a common dry...
Hyperthermia, the elevation of tissue temperature from 42°C to 50°C, is currently being investigated as an adjunct to radiation therapy in the treatment of cancer. The interstitial microwave antenna array hyperthermia (IMAAH) system is designed...
Computer generated 3-D images are proving useful in a wide variety of applications including data visualization, computer animation, virtual reality, telepresence and terrain generation. High-end applications in these fields require images to be...
Alzheimer's Disease (AD) is a devastating neurodegenerative disease its pathogenesis is linked with cholesterol metabolism. Acyl-CoA:cholesterol acyltransferases (ACATs) are key enzymes involved in cholesterol homeostasis that catalyze the...
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
Through a series of case studies, signal processing and statistical tools, analyses of dynamic sea ice processes of drift, deformation, and ice pack expansion and decay are investigated for the Weddell Sea region during 1992. Cavitating fluid (CAV)...
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
Optical tomography. ; Near infrared spectroscopy. ; Image analysis -- Mathematical models. ; Imaging systems -- Image quality -- Mathematical models. ; Image reconstruction -- Mathematical models. ; Least squares. Breast -- Tomography.
Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber...
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
Since their discovery in laboratory plasmas in the 1920s, Langmuir waves have been observed to be ubiquitous in plasma environments, particularly in space plasmas. From the greater solar wind to planetary foreshocks and the auroral ionosphere,...
Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
Phase transitions occur in such diverse and important systems as ferromagnets, liquid crystals and the early Universe. The dynamics of phase transitions such as these have been studied for decades, but the analytical models still need a great deal...
Air -- Pollution. ; Indoor air pollution. ; Air -- Pollution -- Measurement.
The polycyclic aromatic hydrocarbon (PAH) content of ambient air at several locations is described. The indoor sites examined included those having woodstoves, fireplaces, and kerosene heaters as supplements to oil heat, as well as one test home...
This thesis describes a new synthesis of substituted (3H)-1,2-dithiole-3-thiones (dithiolethiones) from readily available starting materials. Dithiolethiones have a wide variety of industrial and pharmaceutical applications. These include use as...
The data presented herein demonstrate the requirement for CD154/CD40 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Blockade of CD154/CD40 interactions causes a decrease in T cell and...