Dartmouth Digital Library Program

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Modular optimization of chemical processes.
Chemical models.
Dartmouth Dissertations

The effect of microstructure on firn gas transport / by Kaitlin M. Keegan
The processes affecting gas transport through the firn column are important to understand in order to accurately interpret climate records from ice cores. Historically, density measurements have been used to estimate open and closed porosity in the...
Dartmouth Dissertations

Characterization of novel cofactors for oncogenic transcription factors Myc and FoxM1 and cytotoxic peptides derived from an essential Myc domain.
Transcription factors -- Genetics. Carcinogenesis. Peptides. Cell cycle -- Regulation. Genetic regulation. Medical Terms: Genes, myc -- genetics; Forkhead Transcription Factors -- genetics; Neoplasm Proteins -- genetics; Trans-Activators --...
Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...
Dartmouth Dissertations

Synthetic studies of Munchnone reactivity and applications and the total synthesis of cyclopenta[B]indole natural products / by Justin M. Lopchuk.
Chapter 1: Munchnones and mesoionic heterocycles The reactivity, regioselectivity, and synthetic applications of munchnones (1,3-oxazolium-5-olates) is a common theme which runs through Chapters 2-5. The definition, structure, and reactivity of...
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

A computational study of radio relics in galaxy cluster mergers / by Dane Patrick Owen.
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...
Dartmouth Dissertations

Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations

The representation of size information in semantic memory.
Memory. Size perception. Semantics.
Dartmouth Dissertations

Synthetic studies on sarpagine alkaloids.
Alkaloids. Organic compounds -- Synthesis.
Dartmouth Dissertations

The role of silver ion in the dimerization of benzocyclobutadiene; Various approaches to tetrakis (triflouromethyl) cyclobutadiene
Cyclobutadiene; Silver ions;
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

On the implementation of ALGOL 68.
ALGOL (Computer program language);Computer programming.
Dartmouth Dissertations

Opinion dynamics in social networks / by Qi Gu.
Opinion dynamics is a complex procedure that entails a cognitive process when it deals with how a person integrates influential opinions to form revised opinion. Early research on opinion formation and social influence can be traced back to the...
Dartmouth Dissertations

Cognitive and neural mechanisms of social motivation / by Katherine E. Powers.
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
Dartmouth Dissertations

Syntheses of transition metal complexes containing fluorinated ligands.
Ruthenium compounds -- Synthesis. ; Organorhodium compounds -- Synthesis. ; Organometallic chemistry.
Dartmouth Dissertations

Diaphragmatic electromyogram and airflow responses to imperceptible mechanical loads in conscious humans
Respiration -- Regulation. ; Pressure breathing.
Dartmouth Dissertations

Synthesis of Elaeocarpus alkaloids via pyrrolinium ion trapping.
Elaeocarpaceae. ; Alkaloids -- Synthesis. ; Pyrrolizidines.
Dartmouth Dissertations

I. Synthesis and cycloaddition reactions of 4H-furo(3,4-b)indoles; II. Novel regioselective fluorobenzyne cycloadditions to furans.
Alkaloids -- Synthesis. ; Carbazole. Furans. ; Condensation.
Dartmouth Dissertations

Multiplicative problems in combinatorial number theory / by Nathan McNew
In this thesis we look at several problems that lie in the intersection between combinatorial and multiplicative number theory. A common theme of many of these problems are estimates for and properties of the smooth numbers, those integers not...
Dartmouth Dissertations

Soil biogeochemistry in temperate and arctic ecosystems : human disturbances to a critical carbon pool / by Chelsea L. Petrenko
I investigated the effects of two contemporary disturbances to soil systems: forest clearing in the northeastern U.S. and climate-driven plant succession in the Arctic. To test the effects of clear-cutting forests on mineral soil carbon (C)...
Dartmouth Dissertations

Thermodynamic Studies of Metal Interactions with Four Biomolecules Using Isothermal Titration Calorimetry / by Margaret C. Carpenter
Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
Dartmouth Dissertations

Anthropogenic changes to mercury and lead biogeochemistry in forest soils across the Northeastern United States / by Justin Byron Richardson
Understanding mercury (Hg) and lead (Pb) accumulation and retention in forest soils is needed to reduce their negative impacts on human and wildlife health. In addition, mercury and lead can be used to characterize the role of soil in terrestrial...
Dartmouth Dissertations

Mechanisms regulating interphase condensin II control of genome organization / by Huy Nguyen
How the genome is shaped directly influences how it is expressed. In fact, the genome is organized at many different levels, each imparting specific regulation over transcription. Fundamental principles regulating genome organization are poorly...
Dartmouth Dissertations

Development of new methods for the synthesis of indolines and quinolizidines / by Hui Li
I. (3 + 2) Cycloaddition Reactions of Oxyallyl Cationic Intermediates with Indoles Cyclopenta- and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 + 2) cycloaddition...
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Constraints on the total binding masses of three double clusters of galaxies.
Galaxies -- Clusters -- Mathematical models. ; Cosmology -- Mathematical models.
Dartmouth Dissertations

Synthesis, characterization, and reactions of octafluorobicyclo[2.2.0]hex-1(4)-ene.
Fluorine compounds -- Synthesis. ; Hexafluorobenzene.
Dartmouth Dissertations

Preparation and reactivity of perfluorobenzyl complexes of the group 9 metals (Co, Rh, Ir).
Organometallic compounds. ; Organofluorine compounds. ; Organic compounds -- Synthesis. ; Transition metals. ; Cobalt compounds -- Synthesis. ; Rhodium compounds -- Synthesis. ; Organoiridium compounds -- Synthesis.
Dartmouth Dissertations

Naming and sharing resources across administrative boundaries.
Electronic data processing -- Distributed processing. ; Computer network architectures. ; Programming languages (Electronic computers) -- Semantics. ; Database management.
I tackle the problem of naming and sharing resources across administrative boundaries. Conventional systems manifest the hierarchy of typical administrative structure in the structure of their own mechanism. While natural for communication that...
Dartmouth Dissertations

Molecular mechanisms of vacuole membrane fusion.
Membrane fusion. ; Tonoplasts. ; Plant vacuoles. ; Saccharomyces cerevisiae -- Molecular aspects.
The docking and fusion of cellular membranes plays an essential role in the secretory and endocytic pathways and in organelle inheritance. The homotypic fusion of vacuoles from the yeast Saccharomyces cerevisiae has been used as a model system to...
Dartmouth Dissertations

Topographic correction of satellite images: theory and application.
Earth sciences -- Remote sensing -- Data processing. ; Remote sensing -- Mathematical models. ; Forests and forestry -- Remote sensing. ; Spectral reflectance. ; Landsat satellites. ; Remote-sensing images -- New Hampshire -- Coos County.
Steep terrain produces a topographic effect in digital satellite data that can make it difficult to distinguish changes in vegetation species or health from changes in illumination geometry. A multiple linear regression analysis of direct solar...
Dartmouth Dissertations

Investigation into the syntheses and reactions of 2-nitroindoles and 3-nitroindoles and discovery of novel syntheses of the pyrrolo[3,4-b]indole and pyrrolo[2,3-b]indole ring systems.
Carbazole -- Synthesis. ; Indole. ; Pyrroles.
A new synthetic approach to both pyrrolo[2,3- b]indoles and pyrrolo[3,4- b]indoles by the reaction of 3-nitro-1-(substituted)indoles with functionalized isocyanides is presented. The reaction between 3-nitro-1-(phenylsulfonyl)indole (185) and ethyl...
Dartmouth Dissertations

Stable isotope paleoclimate studies in the western Basin and Range and greater Yellowstone Region.
Orogeny -- Sierra Nevada (California and Nevada). ; Paleoclimatology -- Sierra Nevada (California and Nevada). ; Paleoclimatology -- Montana. ; Paleoclimatology -- Holocene. ; Metamorphism (Geology) -- Pakistan -- Nanga Parbat.
Dartmouth Dissertations

The mechanical and magnetic properties of FeAl.
Iron-aluminum alloys -- Mechanical properties. ; Iron-aluminum alloys -- Magnetic properties.
The effects of vacancies on the mechanical properties of FeAl single crystals and polycrystals have been investigated. Scanning calorimetric results indicate that vacancies in quenched Fe-40Al undergo rearrangement at ~550K, and then annihilate at...
Dartmouth Dissertations

Providing evidence and measurement tools to support health care reform in communities.
Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
Dartmouth Dissertations

Preparation of sterically hindered bis(secondary phosphines) : structure-selectivity relationships in Pt-catalyzed asymmetric phosphination and synthesis and structure of metal-phosphido complexes.
Phosphorus compounds -- Synthesis. ; Metal complexes -- Synthesis. ; Phosphine. ; Phosphides. ; Platinum catalysts. ; Asymmetric synthesis. ; Gold compounds -- Synthesis.
Dartmouth Dissertations

Carbon-fluorine bond activation of iridium (III) compounds induced by acids and reducing agents.
Organoiridium compounds -- Synthesis. ; Organofluorine compounds -- Synthesis. ; Ligands.
Dartmouth Dissertations

The formation of chloroform and related products from the chlorination of polyhydroxybenzenes and diketones in dilute aqueous solution.
Chloroform. ; Chlorination.
Dartmouth Dissertations

Part I, Synthesis of potentially Möbius aromatic heterocycles; part II, The perfluorotropylium.
Heterocyclic compounds. ; Aromatic compounds -- Synthesis. ; Fluorine compounds. ; Ionization.
Dartmouth Dissertations

Molecular, cellular, and physiological characterization of the insulin receptor substrate 4.
Protein-tyrosine kinase. ; Insulin -- Receptors.
Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
Dartmouth Dissertations

Accurate K/Ar dating of and preservation of oxygen in zeolites.
Zeolites. ; Potassium-argon dating. ; Isotope geology.
Dartmouth Dissertations

Respiratory-related hypoglossal activities in decerebrate cats.
Hypoglossal nerve. ; Airway (Medicine). ; Respiration.
Dartmouth Dissertations

Highly fluorinated keto-enol systems.
Ketones. ; Enols. ; Alkenes. ; Organofluorine compounds.
Dartmouth Dissertations

Strategies for technological change in housing production.
Housing. ; Building -- Cost control. ; Building -- Mathematical models.
Dartmouth Dissertations

Halogenated oxabicyclo[3.2.1]octenes as building blocks for the synthesis of natural products.
Bicyclic compounds -- Reactivity. ; Natural products -- Synthesis. ; Halogens. ; Diels-Alder reaction.
The previously synthesized 3,4-dibromo-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one has been shown to be a very versatile building block for the synthesis of complex natural product structures. This key building block has been made in both...
Dartmouth Dissertations

Sodium borohydride: reactions in acidic media and synthesis of [1n] paracyclophanes.
Sodium borohydride. ; Boron compounds.
Dartmouth Dissertations

Geology of the Lake Atitlan area, Guatemala : a study of subduction zone volcanism and caldera formation.
Geology -- Guatemala -- Lake Atitlan area; Volcanism -- Guatemala -- Lake Atitlan area; Calderas -- Guatemala -- Lake Atitlan area.
Geological mapping, petrological and geophysical studies in the lake Atitlan area, Guatemala, have revealed four distinct periods of stratovolcano growth, each followed by major silicic eruptions and caldera collapse. The first period (12 - 11 my...
Dartmouth Dissertations

Synthetic studies toward the furanosteroids.
Furans -- Synthesis. Steroid drugs. Enzyme inhibitors -- Therapeutic use. Cancer cells -- Growth -- Regulation.
The furanosteroids are an important class of natural products that have been found to effectively inhibit various biologically important enzymes. These enzymes include the phosphoinositide-3-kinase (PI3K) family and the polo-like kinase (PLK1)...
Dartmouth Dissertations

Synthetic studies directed toward investigation of cholesterol regulation.
Cholesterol -- Synthesis -- Regulation. ; Anticholesteremic agents -- Synthesis. ; Squalene.
Chapter II of this thesis describes the synthesis of a number of sulfobetaines and bissulfobetaines to be evaluated as inhibitors of squalene synthase (SS) on the basis of the idea proposed by Shechter that their zwitterionic structure would be...
Dartmouth Dissertations

Development of a multi-high frequency electrical impedance tomography system for breast imaging.
Electrical impedance tomography. Breast -- Imaging. Imaging systems -- Design and construction.
Dartmouth Dissertations

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