Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
The proliferation of mobile devices and other consumer products has greatly expanded the market for CMOS image sensors. This in turn has promoted a trend of continued improvement in image sensor performance, as companies seek to gain an advantage...
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
An important mode of stabilization of cations in biochemical reactions is interaction with the π systems-of aromatic residues. As part of an investigation of the interaction of carbocations with aromatic π systems, a study of various model...
Dipterocarpaceae -- Ecology -- Indonesia -- Kalimantan Barat. ; Rain forest ecology -- Indonesia -- Kalimantan Barat. ; Herbivores -- Ecology.
A decline in population growth as the abundance of a species increases can stabilize population size. In Western Borneo, I found evidence for such density dependence in juveniles of the genus Shorea (Dipterocarpaceae) that dominates southeast...
This thesis is divided into 2 parts. In the first part of the thesis, we describe a software based approach to speeding up the Magnetic Resonance Imaging modality. In the second part of the thesis, we describe Significance Tree Quantization, which...
RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
This research has established feasibility of surface temperature characterization using ruby fluorescence. Study was performed in pin-on-disk geometry, with balls made of different plastics sliding against the sapphire disk. Fluorescence signal was...
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...
Arctic soils in the permafrost region store substantially more carbon than is contained in the atmosphere, and are undergoing rapid change associated with anthropogenic climate change. Soil decomposition is an important component of ecosystem...
Snow -- Permeability. ; Snow surveys -- Antarctica -- East Antarctica. ; Surfaces -- Areas and volumes. ; Gas flow. ; Porosity.
Recent field investigations of a megadunes region of East Antarctica provide evidence that differences in grain size, thermal conductivity, and permeability across a megadune are due to relative accumulation patterns in the absence of significant...
Electric fields in the high-latitude regions of Earth's ionosphere are an important component of the coupled magnetosphere-ionosphere-thermosphere system. Characterizing the average behavior of these fields (or the corresponding drifts) is useful...
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
This dissertation explores the spatial and temporal distributions of impurities in natural ice. Using polarized light, ion chromatography (IC), synchrotron x-ray topography (SXT), scanning electron microscopy (SEM), and energy-dispersive...