Dartmouth Digital Library Program

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Preparation and characterization of aqueous nanoparticles from molecular and macromolecular amphiphiles.
Nanoparticles -- Synthesis. Polymer colloids. Lipids -- Synthesis.
Colloidal nanoparticles are particles with sizes ranging from one nanometer to several hundred nanometers, which disperse evenly in a dispersion medium. In aqueous solutions, amphiphilic molecules organize themselves to form such colloidal systems...
Dartmouth Dissertations

Damage identification using sensitivity enhancing control with an identified model.
Automatic control -- Sensitivity. Structural control (Engineering). Strains and stresses -- Computer simulation. Structural analysis (Engineering). Engineering models.
Autonomous damage detection in engineering structures is critically important as the demands placed upon those structures are increased. It has been well established that damage detection can be done through monitoring the modal frequencies of the...
Dartmouth Dissertations

Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
Dartmouth Dissertations

Computational aspect of tomographic microwave imaging for biomedical applications
Microwave imaging (MI) is based on recovering dielectric properties (permittivity and conductivity) of materials. Over the last two decades, MI has attracted increasing interests in biomedical applications, in particular, for breast cancer...
Dartmouth Dissertations

Zinc homeostasis in Arabidopsis: the role of ZIP metal transporters.
Zinc -- Physiological transport. Arabidopsis thaliana -- Physiology. Homeostasis. Trace elements in plant nutrition.
Zinc deficiency is a widespread and common problem in many organisms. In plants, zinc deficiency causes growth inhibition, resulting in reduced final yields. Although zinc is an essential element in plants, zinc uptake, translocation and...
Dartmouth Dissertations

Understanding inpatient nurses' engagement in worksite health promotion: a case study.
Nurses -- Health and hygiene. Employee health promotion.
Background. Worksite health promotion programs (HPP) support employees' health behaviors to prevent downstream diseases. Maximizing participation can optimize program impact. Objectives. To assess staff nurses' participation in three HPP - flu...
Dartmouth Dissertations

Fractal models in the visual perception of textures and surfaces in nature.
Visual perception. Fractals. Computer graphics. Uniformity of nature -- Mathematical models.
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Automated forensic techniques for locating zero-day exploits / by Stephen Kuhn.
This thesis approaches the problem of locating zero-day exploits used in network attacks. The hypothesis is that the advent of high-performance virtualization presents a unique opportunity to both discover these events and increase the attacker's...
Dartmouth Dissertations

Characterization of short latency respiratory-related evoked potentials (RREPs) recorded using a noncephalic reference.
Respiration -- Regulation. Respiratory organs -- Physiology. Neurophysiology.
Dartmouth Dissertations

Natural image statistics for digital image forensics.
Image processing -- Statistical methods. Image processing -- Digital techniques. Images
We describe a set of natural image statistics that are built upon two multi-scale image decompositions, the quadrature mirror filter pyramid decomposition and the local angular harmonic decomposition. These image statistics consist of first- and...
Dartmouth Dissertations

Optimizing winding designs for high-frequency magnetic components.
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...
Dartmouth Dissertations

A proof that essergy is the only consistent measure of potential work (for chemical systems).
Force and energy. ; Thermodynamics. ; Chemistry Physical and theoretical
Dartmouth Dissertations

Large-scale structure of the universe: a clustering analysis.
Cosmology -- Mathematical models. ; Galaxies -- Clusters -- Mathematical models. ; Dark matter (Astronomy).
Dartmouth Dissertations

Observational study of dynamic structures at the magnetopause.
Magnetopause. ; Magnetopause -- Remote sensing. ; Magnetosphere -- Remote sensing. ; Magnetohydrodynamics -- Observations.
Dartmouth Dissertations

Signal processing bases and the Jacobi group.
Bases (Linear topological spaces). ; Signal processing -- Mathematics. ; Hilbert space. ; Functions Orthogonal.
Dartmouth Dissertations

Regulation of peripheral tolerance by mast cells.
Mast cells -- Immunology. Mast cells -- Physiology. Dendritic cells. Immunological tolerance -- Molecular aspects. Medical Term Cell Degranulation.
Mast cells (MC) have until recently been regarded as pro-inflammatory, however this view changed with the observation that the absence of MC impairs the development of transplant tolerance to allografts. However, little is known about whether MC...
Dartmouth Dissertations

ACAT1 knockdown gene therapy in a mouse model of Alzheimer's disease / by Stephanie Rachel Murphy.
Alzheimer's Disease (AD) is a devastating neurodegenerative disease its pathogenesis is linked with cholesterol metabolism. Acyl-CoA:cholesterol acyltransferases (ACATs) are key enzymes involved in cholesterol homeostasis that catalyze the...
Dartmouth Dissertations

Electrochemical intramolecular cyclizations involving silyl enol ethers and appended heterocycles.
Ring formation (Chemistry). ; Heterocyclic compounds -- Synthesis. ; Ethers. ; Enols.
Synthetic electrochemistry is a rapidly growing area of interest within the synthetic community, although it is far from being a routine technique. Despite the fact that many oxidative and reductive conversions are known, electrochemical methods...
Dartmouth Dissertations

Site-specific modification of glycoproteins expressed in an engineered strain of Escherichia coli.
Glycoproteins -- Synthesis. Escherichia coli -- Biotechnology. Bioconjugates -- Synthesis. Protein engineering.
We have created an E. coli based platform for protein modification by coupling an engineered glycosylation pathway with a subsequent chemoenzymatic labeling strategy in which the glycans are oxidized to provide a bioorthogonal aldehyde group that...
Dartmouth Dissertations

Regulation of innate immunity of mouse uterine epithelial cells by keratinocyte growth factor and estradiol.
Epithelial cells. Uterus -- Physiology. Keratinocytes -- Physiological effect. Estradiol -- Physiological effect. Growth factors -- Physiological effect. Chemokines.
The mucosal immune system of the female reproductive tract (FRT) balances the dual functions of protection against invading pathogens and adaptation of the endometrial environment for successful fertilization and implantation. Growth factors are...
Dartmouth Dissertations

Innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency / by Megan Ashley O''Connor
LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), and is characterized by profound and broad immunosuppression of T- and B-cell responses. Adaptive immune response to LP-BM5 infection, including the pathogenic role of CD4+ T-cells and...
Dartmouth Dissertations

Landscape response to climate forcing: quantifying mechanisms and rates of erosion and weathering along an orographically-enhanced climate gradient.
Climatic geomorphology -- Sierra Nevada (California and Nevada). ; Slopes (Physical geography) -- Sierra Nevada (California and Nevada). ; Weathering -- Sierra Nevada (California and Nevada). ; Chemical denudation -- Sierra Nevada (California and...
Landscapes evolve in response to external forcings such as climate and tectonics that influence the pace and patterns of erosion and weathering processes. Furthermore, internal feedbacks between erosion and weathering regulate the expression of...
Dartmouth Dissertations

Innate immune responses to HIV-1 and Chlamydia trachomatis in the human female reproductive tract / by Lucy Rudo Mukura.
Female reproductive tract (FRT) secretions contain a spectrum of cytokines, chemokines and antimicrobials that inhibit infection of target cells by HIV-1 and other sexually transmitted pathogens. Innate immune protection maintained by the presence...
Dartmouth Dissertations

Behavior therapy for phobias (extinction of avoidance) in rats.
Extinction (Psychology); Avoidance (Psychology); Behavior therapy.
Dartmouth Dissertations

Heart rate and palmar skin conductance in anticipation of painful electric shock.
Stress (Physiology). Psychophysiology.
Dartmouth Dissertations

High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

Synthesis, characterization, and reactions of octafluorobicyclo[2.2.0]hex-1(4)-ene.
Fluorine compounds -- Synthesis. ; Hexafluorobenzene.
Dartmouth Dissertations

The consequences of acute and chronic ambivalence for cognitive functioning, emotion, and attention / by Sarah E. Henderson.
Although ambivalence is not an everyday emotional state, it is quite prevelent during critical behavioral and life changes (e.g., smoking cessation). The goal of the present thesis was to understand the relationships between acute (Aim 1) and...
Dartmouth Dissertations

14-3-3 sigma modulates pancreatic cancer cell survival and invasiveness.
Pancreas -- Cancer -- Pathophysiology. Pancreatic duct -- Pathophysiology. Proteins -- Pathophysiology. 14-3-3 Proteins -- physiology. Pancreatic Neoplasms -- pathology.
14-3-3 is down-regulated in certain human cancers, but its expression is increased in pancreatic ductal adenocarcinoma (PDAC). The purpose of the present study was to investigate the potential role of 14-3-3σ in PDAC. The levels of 14-3-3...
Dartmouth Dissertations

Immunomodulation and the prevention of pathogen-driven ileitis.
Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

The Pseudomonas fluorescens pho regulon and its role in modulating biofilm formation in response to environmental cues.
Pseudomonas fluorescens -- Genetics. Attachment mechanisms (Biology) Biofilms -- Growth. Phosphates -- Physiological effect. Medical Term: Biofilms -- growth and development. Adhesins, Bacterial.
Microbial biofilm formation is thought of as a developmental pathway, whereby cells progress through environmentally regulated and temporally distinct stages during transition from free-swimming lifestyles to members of a structured...
Dartmouth Dissertations

TGF-beta1 regulation of Th1 development and autoimmunity.
Transforming growth factors-beta. ; Th1 cells. ; Transcription factors. ; Autoimmunity. ; Cytokines. ; Immune response -- Regulation. ; T cells. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Chemical ecology : bacterial phenazines as toxins and paracrine signals in Candida albicans / by Diana K. Morales Gamba.
Supernovae -- Observations.;""Supernova remnants -- Observations."";""Supernovae -- Spectra.""
Dartmouth Dissertations

The role of the genes tra-4 and glp-5 in C. elegans development.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Generative organs. ; Caenorhabditis elegans -- Development. ; Genetic transcription -- Regulation.
Sex determination in C. elegans leads to the development of sex-specific structures and contributes to the regulation of sexually dimorphic programmed cell death. A search for factors that regulate the sexually dimorphic cell death of the...
Dartmouth Dissertations

Regeneration studies of a single indentifiable motoneuron in the crayfish Procambarus Clarkii.
Motor neurons. ; Nervous system -- Regeneration. ; Crayfish.
Dartmouth Dissertations

Interrogation of autolysins as a source of novel bacteriolytic agents / by Daniel Carmen Osipovitch
Staphylococcus aureus is a formidable pathogen, and its high morbidity and mortality rates are compounded by its ability to quickly develop antibiotic resistance. The current antimicrobial pipeline is inadequate to curb this mounting public health...
Dartmouth Dissertations

Hormonal and neurochemical determinants of sex differences in chronic radicular pain.
Radiculitis -- Endocrine aspects. Radiculitis -- Sex factors. Radiculitis -- Pathophysiology. Pain -- Sex factors. Progesterone -- Physiological effect. Cellular signal transduction. Neuregulin-1 -- physiology.
Chronic low back pain is a debilitating and devastating disease affecting millions of people worldwide. Considerable evidence indicates that there are sex-related differences in clinical and experimental pain sensitivity in men and women. Women...
Dartmouth Dissertations

An infrared Cerenkov laser.
Cherenkov radiation. ; Infrared radiation.
Dartmouth Dissertations

Computer based electron beam treatment planning.
Radiotherapy. ; Electron beams. ; Computers.
Dartmouth Dissertations

Evidence based practice in neonatal intensive care: the effect of prophylactic topical emollient ointment therapy and systemic antibiotic administration practices on nosocomial sepsis rates and mortality in extremely low birth weight infants 501 to...
Neonatal intensive care. ; Evidence-based medicine. ; Nosocomial infections -- Prevention. ; Ointments -- Effectiveness. ; Antibiotics -- Effectiveness.
Introduction. Nosocomial sepsis in extremely low birth weight (ELBW) infants 501-1000 grams is associated with increased mortality risk, prolonged hospitalization, and increased costs of care. Purpose. The purpose of this thesis was to evaluate the...
Dartmouth Dissertations

Hybrid code simulation of electromagnetic ion cyclotron waves in curvilinear coordinates.
Cyclotron waves -- Mathematical models. Curvilinear coordinates. Nonlinear theories
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Distinct functions for diguanylate cyclases in regulating Pseudomonas aeruginosa PA14 surface-associated behaviors.
Pseudomonas aeruginosa -- Genetics. Biofilms -- Growth. Bacteria -- Motility. Guanylate cyclase. Cellular signal transduction.
Biofilm formation is a complex process culminating in a multicellular microbial structure encased in an extracellular matrix. In order for planktonic cells to initiate and proceed through biofilm formation, they must appropriately regulate a number...
Dartmouth Dissertations

Characterization and engineering of alginate lyases: assessing therapeutic revelance
Chronic infection of the human airway by mucoid Pseudomonas aeruginosa is cited as the leading cause of death among Cystic Fibrosis patients. The persistent nature of these infections is linked to P. aeruginosa's ability to form protective biofilm...
Dartmouth Dissertations

The dual role of the Pseudomonas aeruginosa type I-F CRISPR-Cas system in group behavior modification and viral immunity / by Gary E. Heussler
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been characterized as adaptive immune systems in bacteria and archaea, providing defense against mobile genetic elements, including bacteriophage,...
Dartmouth Dissertations

Osmium geochemistry of natural waters.
Osmium -- Isotopes. Hydrogeology. Water chemistry.
Dartmouth Dissertations

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