Proteins, the basic structural and functional building blocks of cellular machinery, evolve under significant constraint. Evolutionary pressures limit the acceptable variation and covariation of amino acids in a protein. As such, these evolutionary...
The recognition of foreign peptides by MHC (Major Histocompatibility Complex) proteins is a critical step in the immune response mounted by higher vertebrates against pathogens. MHC proteins have many allelic variants, each recognizing different...
Safety in transportation systems is a global concern with millions of road accidents happening worldwide every year. Despite sophisticated advancement in automotive design and accident serverity reduction technologies, traffic fatalities continue...
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
This thesis focuses on the emergence of universal dynamical scaling in quantum critical spin systems driven out of equilibrium, with emphasis on quench dynamics which involves isolated standard critical points, multi-critical points, and...
Information retrieval -- Mathematical models. ; Electronic information resource searching. ; Computer algorithms. ; Decision making -- Data processing. ; Mathematical optimization.
This thesis presents a unified method for simultaneous solution of three problems in Information Retrieval--metasearch (the fusion of ranked lists returned by retrieval systems to elicit improved performance), efficient system evaluation (the...
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...
For a long-lived metastable system, the decay of the survival probability is typically exponential. However, deviations are known to exist at short times (the quantum Zeno effect) and at long times (algebraic tails in classical hydrodynamic...
Free electron lasers. ; Cherenkov radiation. ; Far infrared lasers. ; Lasers -- Resonators.
In the far infrared region of the electromagnetic spectrum, 15-3000 Î¼m in wavelength, there is a lack of narrow band sources. The Cerenkov free electron laser (CFEL) shows promise to fill this gap. The Cerenkov resonator was analyzed theoretically...
The ability to forecast the weather of the geospace environment depends critically on the ability to accurately model the dynamics of the coupled magnetosphere-ionosphere (MI) system. The MI interaction involves a set of electrodynamic and plasma...
Modern distributed systems scatter sensors, storage, and computation throughout the environment. Ideally these devices communicate and share resources, but there is seldom motivation for a device''s owner to yield control to another user. We...
Graph algorithms. Nuclear magnetic resonance spectroscopy -- Data processing. Proteins -- Structure -- Mathematical models. Proteins -- Crosslinking -- Mathematical models. Protein folding -- Mathematical models.
The study of three-dimensional protein structures produces insights into protein function at the molecular level. Graphs provide a natural representation of protein structures and associated experimental data, and enable the development of graph...
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
The processes by which nonlinear physical systems approach thermal equilibrium is of great importance in many areas of science. Central to this is the mechanism by which energy is transferred between the many degrees of freedom comprising these...
Two auroral sounding rocket case studies, one in the dayside and one in the nightside, explore aspects of poleward boundary aurora. The nightside sounding rocket, Cascades-2 was launched on 20 March 2009 at 11:04:00 UT from the Poker Flat Research...
Cosmic acceleration could be an effect of a ""dark energy"" fluid pervading the Universe. It could also be an indication that general relativity is not the correct theory of gravity at cosmological length scales. Unfortunately, observations of the...
Sensor networks are used in many realtime applications for collecting information from monitored environments and objects, such as moving vehicle tracking, battlefield reconnaissance, and habitat monitoring. Sensor networks are often deployed in...
The main research objective of this thesis is to address distributed target tracking for mobile sensor networks. Based on real-life limitations, we are particularly interested in mobile sensors with Limited Sensing Range (LSR). There are three...
Electric inductors -- Design and construction.;""DC-to-DC converters -- Design and construction."";""Thin film devices -- Design and construction."";""Microfabrication."";""Magnetic films."";""Thin films Multilayered."";""Granular...
Fluorine forms the strongest single bond to carbon, however, it is well established that transition metals can lengthen and weaken C-F bonds in fluorinated ligands. Described here are studies on the activation of C-F bonds in iridium compounds...
The thermophilic anaerobic bacterium Clostridium thermocellum has attracted researchers attention because of its potential industrial application and high cellulose hydrolysis rates. This study focuses on the physiological fundamentals of C....
Chromatin -- Structure. DNA -- Methylation. Globin genes -- Expression. Adenosine triphosphatase. Proteins -- Chemical modification.
Epigenetic regulation of gene expression is a developing field of study with many potential therapeutic applications. Chromatin remodeling is necessary for proper mammalian development, and misregulation of this process is associated with many...