Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
H-NS, an abundant nucleoid associated protein, has a role in silencing the expression of a variety of environmentally regulated genes during growth under nonpermissive conditions. A genetic approach was used to study H-NS regulation of genes in...
A variety of forensic methods have been developed to identify falsified photos, each unified by the ability to estimate and detect properties of a photo that are perturbed by forgery. There exist, however, many photos in which the required...
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Naturally occurring macrocyclic tetrapyrroles of the chlorin and bacteriochlorin classes play important roles in essential biological processes, including photosynthesis and nitrogen cycling. The chromophores also show promise in various...
Protein complexes play vital roles in cellular processes within living organisms. They are formed by interactions between either different proteins (hetero-oligomers) or identical proteins (homo-oligomers). In order to understand the functions of...
Mentally ill -- Care -- Decision making. Mental illness -- Treatment -- Decision making. Mental health services -- Decision making. Mental health -- Information services. Medical informatics. Mental Disorders -- drug therapy.
Objective. We explored preferences and perceptions about treatment decision-making roles among persons with severe mental illness and evaluated two computer-based medication values clarification tools. Methods. In this study we conducted a pilot...
Ice mechanics. Compressibility. Fracture mechanics. Strains and stresses. Brittleness.
This work describes the effect of triaxial compressive confinement on the strength of columnar S2 ice loaded under conditions leading to brittle failure. Cubes of columnar S2 ice were tested at -10 °C under triaxial (proportional) loading where...
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
Eddy currents (Electric) -- Mathematical models. Electric generators -- Windings. Finite element method.
Magnetic components, such as transformers and inductors, are essential parts of most power electronics circuits. They usually are the largest components in the circuit, and also account for a large portion of the power loss. Reducing the volume of...
Interaction with aromatic π systems has become recognized as an important mode of stabilization of carbocation intermediates in biological reactions. To gain insight into such carbocation-π interactions, we have undertaken a study of...
In large and complex networks such as the Internet and road networks, traffic routing is typically decentralized. Users in the network choose their routes independently to minimize their own delay, leading to complicated and nonintuitive outcomes...
Brain -- Tomography. Magnetic resonance imaging -- Brain. Near infrared spectroscopy. Image processing -- Digital techniques.
Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and...
Fluorine forms the strongest single bond to carbon, however, it is well established that transition metals can lengthen and weaken C-F bonds in fluorinated ligands. Described here are studies on the activation of C-F bonds in iridium compounds...
Primary care (Medicine) -- United States -- Evaluation.
Medicine -- Specialties and specialists.
Physicians -- Supply and demand -- United States.
Background: Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Nutrients play fundamental roles in biological systems, affecting plant growth and quality, community structure, and species interactions. Although the effects of nutrients on primary and secondary production have been well documented, their...
Escherichia coli is the standard host for recombinant protein expression in bacteria, but suffers from some limitations (e.g. poor fermentation performance, inclusion body formation and proteolysis). A novel recombinant protein expression system,...
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and...
Laser speckle monitoring is a way to measure the motion of an optically rough surface without making physical contact to that surface. Laser speckle is inherently sensitive to motion in the plane of the reflecting surface, which gives speckle...
The furanosteroid class of compounds issues a siren call to both chemists and biologists alike -- the intriguing pentacyclic skeleton, densely packed and highly functionalized, continues to entice synthetic minds to develop new and elegant methods...
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....