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left to right, James W. LaBelle, Ph.D., Professor ...
2004-03-30_labelle+
Dartmouth College Photographic Records

Within and between hand acquisition of multiple stimulus-response mappings.
Hand -- Psychophysiology. Conditioned response. Hand -- Movements. Perceptual-motor processes.
The present studies examine the flexible application of two stimulus-response (SR) mappings to a single set of stimuli. The following questions are addressed: (1) Can dual mapping performance equal single mapping performance (2) Can rapid map...
Dartmouth Dissertations

Modulation of CYPS: effect on acetaminophen hepatotoxicity.
Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
Dartmouth Dissertations

The effect of film structure on the optical conductivity of thin Ta and Mn films.
Thin films -- Optical properties. ; Metallic films -- Optical properties. ; Optical films.
Dartmouth Dissertations

Chemical processing of atmospheric inputs by subalpine balsam fir.
Balsam fir. ; Forest ecology. ; Air -- Pollution -- Environmental aspects. ; Plants -- Effect of air pollution on.
Dartmouth Dissertations

Examining relationships between health beliefs and medical decisions in the context of medical uncertainty.
Medical care -- Decision making. Health attitudes. Prostate -- Cancer -- Treatment -- Decision making. Prostate -- Cancer -- Patients -- Attitudes. Uncertainty. Video recording in medicine.
This dissertation used two studies to evaluate the appropriateness of a theoretical model exploring the relationships between screening/treatment beliefs and intending to be screened or treated for prostate cancer (P-CA). Study One examined...
Dartmouth Dissertations

Interspecific interactions and population dynamics of the Southern pine beetle.
Southern pine beetle -- Ecology. Mutualism (Biology). Commensalism.
A challenge for ecologists is to identify and understand the mechanisms that produce population behaviors in nature. This is particularly difficult in complex communities that comprise of tightly linked multivoltine organisms that are...
Dartmouth Dissertations

A catalog of clusters to z [is less than or equal to] 1 from the Oxford Dartmouth Thirty Degree Survey.
Galaxies -- Clusters -- Mathematical models. Galaxies -- Formation -- Mathematical models. Galaxies -- Clusters -- Catalogs. Galaxies -- Spectra. Algorithms. Andromeda Galaxy.
A sample of 46 previously unidentified, intermediate- to high-redshift, near-infrared (NIR)-selected galaxy clusters have been discovered in the Andromeda catalog of the Oxford Dartmouth Thirty Degree Survey (ODTS). These clusters vary from low- to...
Dartmouth Dissertations

The impact of prenatal and postnatal home visiting on utilization of care.
Home care services -- Utilization -- New Hampshire. Home care services -- New Hampshire -- Evaluation. Maternal health services -- Utilization -- New Hampshire. Infant health services -- Utilization -- New Hampshire. Prenatal care -- Utilization --...
Research objective . Research suggests that home visiting services can have a significant impact on pregnancy outcomes, child health and development, parenting and maternal life course. The effect of home visiting on utilization of health services...
Dartmouth Dissertations

Steady state NMR imaging of cerebral blood volume as an index of chronic hypoxia induced angiogenesis.
Neovascularization. Brain -- Blood-vessels -- Magnetic resonance imaging. Blood volume -- Measurement. Cerebral circulation -- Measurement. Anoxemia. Blood Volume Determination -- methods.
Angiogenesis is part of the natural defense mechanism in brain against hypoxia and ischemia. Animal models and methods for the non-invasive investigation of cerebral angiogenesis are needed. This thesis addresses the hypothesis that steady state,...
Dartmouth Dissertations

Functionalization of fluorocarbons.
Fluorocarbons -- Synthesis. Fluorocarbons -- Derivatives. Activation (Chemistry). Polytef -- Surfaces. Organofluorine compounds -- Synthesis.
The great strength of the C-F bond has enabled fluorocarbons to find many industrial and domestic applications, and makes C-F activation a chemical and technical challenge akin to that of C-H bond activation in hydrocarbons. In our mission to...
Dartmouth Dissertations

Three dimensional shape analysis with parametric surface modeling.
Geometrical models -- Data processing. Three-dimensional display systems. Diagnostic imaging -- Mathematical models. Hippocampus (Brain) -- Imaging. Spherical harmonics. Computer vision -- Mathematical models. Computer algorithms.
Shape modeling is an important area in computer vision and medical imaging. Shape models have proved valuable in the tasks of object representation, recognition, and classification. This thesis focuses on shape models of 3D surfaces extracted from...
Dartmouth Dissertations

Gain experiments with a grating based free electron laser.
Free electron lasers -- Experiments. Wave guides -- Design and construction. Diffraction gratings -- Experiments. Electron beams. Infrared sources.
The far infrared region of the electromagnetic spectrum, 15-3000 Œºm in wavelength, has a paucity of narrow band laser sources. To address the issue of whether a grating based free electron laser could operate well as such a source, a grating...
Dartmouth Dissertations

Data assimilation in brain deformation modeling.
Diagnostic imaging -- Digital techniques. Diagnostic imaging -- Mathematical models. Image processing -- Mathematics. Intraoperative monitoring. Brain -- Magnetic resonance imaging. Ultrasonic encephalography.
One of the important challenges facing image-guided neurosurgery is the fact that the brain deforms significantly over the course of an operation during open-cranial procedures. This results in a loss of registration between the brain and the...
Dartmouth Dissertations

Synthetic and mechanistic studies in tetrapyrrole chemistry.
Tetrapyrroles -- Synthesis. Tetrapyrroles -- Mechanism of action. Transition metal catalysts.
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
Dartmouth Dissertations

Radical methodologies with indole and synthetic strategies towards the indole alkaloids, echitamine and prenostodione.
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
Dartmouth Dissertations

The impact of sodium channel isoform expression on cerebellar Purkinje cell development.
Purkinje cells. Sodium channels -- Genetic aspects. Excitation (Physiology). Neurons -- Physiology. Cerebellum -- Physiology. Genetic regulation.
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Dartmouth Dissertations

New synthetic approaches to chlorins and bacteriochlorins.
Pyrroles -- Synthesis. Porphyrins -- Synthesis.
Naturally occurring macrocyclic tetrapyrroles of the chlorin and bacteriochlorin classes play important roles in essential biological processes, including photosynthesis and nitrogen cycling. The chromophores also show promise in various...
Dartmouth Dissertations

Synthesis and characterization of phosphido-coated gold nanoclusters and gold phosphido complexes.
Gold -- Analysis. Gold compounds. Metal complexes -- Synthesis. Phosphides. Ligands.
Chapter one: Gold(I) phosphido complexes: Synthesis, structure and reactivity . Deprotonation of the phosphine complexes Au(PHR 2 )Cl with aqueous ammonia gave the gold(I) phosphido complexes [Au(PR 2 )] n (PR 2 = PMes 2 ( 1 ), PCy 2 ( 2 ), P(t-Bu)...
Dartmouth Dissertations

Valuing health for economic evaluation in spine disorders.
Health status indicators -- Measurement. Health surveys -- Methodology. Medical economics. Spine -- Diseases.
Several ""health state classification systems"" are available to estimate health state values (HSV) for economic evaluation. Evidence of variation in estimates from different systems raises concern that system choice may affect study conclusions...
Dartmouth Dissertations

Examining auroral downward current region processes using ground based data.
Auroras -- Alaska -- Observations. Magnetospheric currents.
This thesis presents data from ground camera observations of the aurora conducted from Alaska during the winters of 2005 through 2007. In conjunction with these camera observations, conjugate radar observations of the auroral ionosphere were...
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

Towards the experimental verification of macroscopic phenomena in quantum electrodynamics.
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

Physiological and neural mechanisms of anxiety, negativity, and threat.
Anxiety -- Physiological aspects. Threat (Psychology) -- Physiological aspects. Amygdaloid body -- Psychophysiology. Brain -- Psychophysiology.
The objective of this thesis was to examine the neural and physiological substrates underlying the processing of aversive information, and how individual differences in anxiety influence these responses. In a series of experiments, we utilized skin...
Dartmouth Dissertations

Inf2-formin that polymerizes and depolymerizes actin on endoplasmic reticulum.
Actin. Microfilament proteins. Polymerization. Endoplasmic reticulum.
Dartmouth Dissertations

Kinematics and space densities for the local cataclysmic variable population.
Cataclysmic variable stars. Kinematics.
I investigate the kinematics and space densities of the local cataclysmic variable (CV) population. CVs are close binary star systems composed of a white dwarf that accretes matter from a less compact companion star in Roche lobe overflow....
Dartmouth Dissertations

Restraint and disinhibition in the brain.
Self-control -- Physiological aspects. Nucleus accumbens -- Psychophysiology. Reducing diets -- Psychological aspects. Eating disorders -- Psychological aspects. Promiscuity -- Psychological aspects.
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
Dartmouth Dissertations

I. Reactivity of electron deficient indoles toward nucleophiles, Diels-Alder reactions and dipolar cycloadditions; II. Synthesis of pyrrolo[3,4-b]indoles.
Indole -- Synthesis. Indole -- Reactivity. Pyrroles. Diels-Alder reaction.
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
Dartmouth Dissertations

Spatial feature extraction algorithms.
Image processing -- Digital techniques. Spatial systems -- Data processing. Pattern recognition systems. Computer algorithms.
Dartmouth Dissertations

Effects of particles on anelasticity, creep and microstructural evolution of granular ice.
Ice mechanics. Internal friction. Ice -- Creep. Particles. Dislocations in crystals.
This work studied the effects of silt-sized particles on the mechanical properties and microstructures of laboratory-grown granular ice from -20¬∞C to -2¬∞C. Experimental findings show that such particles significantly affect the...
Dartmouth Dissertations

Versatile 2-lithioindoles, syntheses and Diels-Alder reactions of pyrrolo[3,4-b]indoles.
Indole alkaloids -- Synthesis. Diels-Alder reaction.
An efficient synthetic approach to both 2-acyl-1-(substituted)indoles and 2-nitro-1-(substituted)indoles by reaction of 2-lithio-1-(substituted)indoles with appropriate electrophiles is presented. Inverse quenching of 2-lithioindoles 5 and 208 with...
Dartmouth Dissertations

Sounding rocket investigations of whistler, upper hybrid and Langmuir waves in the auroral ionosphere.
Auroras -- Alaska -- Observations. Ionospheric radio wave propagation -- Observations. Sounding rockets. Electromagnetic waves -- Observations. Whistlers (Radio meteorology) -- Alaska -- Observations.
In this thesis data from four sounding rocket experiments (PHAZE II, SIERRA, RACE and HIBAR) are used to explore the high and medium frequency waves seen in the auroral ionosphere. All rockets were launched into active aurora and carried both...
Dartmouth Dissertations

Part I, a photoprecursor for difluorocarbene: Part II, syntheses and studies of the highly fluorinated [2.2.2] propellanes.
Organofluorine compounds -- Synthesis. Carbenes (Methylene compounds) -- Synthesis. Propellanes -- Synthesis.
Part I. A photoprecursor for difluorocarbene . The goal of this research was to develop a more practical and efficient photoprecursor for difluorocarbene. The first approach was concerned with the synthesis of 4,4-difluoropyrazoline-3,5-dione ( 5...
Dartmouth Dissertations

Design, fabrication, control, and programming of MEMS micro-robots.
Microelectromechanical systems. Robotics.
This thesis presents technologies for the design, fabrication, operation, and control of electrostatic MEMS micro-robots. It describes prototype micro-robots, with dimensions of 60 μm by 250 μm by 10 μm, that are capable of controllable...
Dartmouth Dissertations

Stereopsis-guided brain shift compensation.
Three-dimensional imaging in medicine -- Mathematical models. Intraoperative monitoring. Cerebral cortex -- Imaging. Computer vision. Space perception.
Brain deformation models have proven to be a powerful tool in compensating for soft tissue deformation during image-guided neurosurgery. The accuracy of these models can be improved by incorporating intraoperative measurements of brain motion. We...
Dartmouth Dissertations

Investigation, optimization and synthesis of dihydrodipyrrins, linear tetrapyrroles and the resulting chlorins.
Porphyrins -- Synthesis. Tetrapyrroles -- Synthesis.
The synthesis of macrocyclic tetrapyrroles continues to be an area of vigorous research due to their application to a wide range of fields spanning the physical sciences. Only recently have general syntheses for the reduced systems, such as...
Dartmouth Dissertations

Enolase in vacuole fusion and enolase and Bor1p in trafficking of proteins to the vacuole in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Membrane fusion. Plant vacuoles. Biological transport -- Regulation. Saccharomyces cerevisiae -- Cytology.
Dartmouth Dissertations

The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
Dartmouth Dissertations

The role of glia in neuropathic pain: a journey into the tetrapartite synapse.
Neuroglia -- Effect of drugs on. Astrocytes. Opioids -- Physiological effect. Central nervous system -- Pathophysiology. Nerves
Neuropathic pain is a debilitating condition that affects millions of individuals worldwide. Unfortunately, opioids are only partially effective in treating neuropathic pain while entraining tolerance and a myriad of side effects from the high...
Dartmouth Dissertations

Synthetic studies toward the furanosteroids.
Furans -- Synthesis. Steroid drugs. Enzyme inhibitors -- Therapeutic use. Cancer cells -- Growth -- Regulation.
The furanosteroids are an important class of natural products that have been found to effectively inhibit various biologically important enzymes. These enzymes include the phosphoinositide-3-kinase (PI3K) family and the polo-like kinase (PLK1)...
Dartmouth Dissertations

Catalytic asymmetric P-C bond formation with Pt-phosphido complexes.
Organoplatinum compounds -- Synthesis. Organoplatinum compounds -- Reactivity. Organophosphorus compounds -- Synthesis. Organophosphorus compounds -- Reactivity. Asymmetric synthesis. Phosphate carbon. Platinum catalysts.
Chapter One. Synthesis and Structure of Chiral Pt(Duphos) Terminal Phosphido Complexes. Treatment of Pt halide precursors with a secondary phosphine in the presence of the base NaOSiMe 3 gave the terminal phosphido complexes Pt(Duphos)(Ph)(PMeIs)....
Dartmouth Dissertations

Fine structure in auroral radio emissions.
Ionospheric radio wave propagation -- Observations. Hiss (Radio meteorology). Auroras -- Antarctica -- Observations.
A VersatIle Electromagnetic Waveform (VIEW) receiver was deployed at South Pole station in December 2002 in order to measure the fine structure of auroral radio emissions with high resolution and an unprecedented 500-1000 kHz bandwidth. Using this...
Dartmouth Dissertations

The resistance to sliding along Coulombic shear faults in columnar S2 ice.
Ice mechanics. Friction. Shear (Mechanics). Strains and stresses. Ice -- Brittleness. Ice -- Ductility.
Dartmouth Dissertations

Development of a multi-high frequency electrical impedance tomography system for breast imaging.
Electrical impedance tomography. Breast -- Imaging. Imaging systems -- Design and construction.
Dartmouth Dissertations

Geographic access, utilization, and outcomes in lung, breast, prostate, and colorectal cancer patients at NCI-designated cancer centers.
Cancer Control Program (National Cancer Institute) -- Evaluation. Cancer -- Treatment -- United States -- Evaluation. Cancer -- Patients -- Care -- Evaluation.
Background. Disparities in access to cancer care and cancer-related outcomes have been demonstrated in the U.S. Patterns of access to National Cancer Institute-designated Cancer Centers (NCI-CCs), the most specialized cancer care settings, have not...
Dartmouth Dissertations

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