Proteins -- Structure -- Mathematical models. Recombinant proteins -- Mathematical models. Mathematical optimization -- Data processing. Dynamic programming. Protein engineering.
Site-directed protein recombination produces improved and novel protein variants by recombining sequence fragments from parent proteins. The resulting hybrids accumulate multiple mutations that have been evolutionarily accepted together. Subsequent...
Electric generators -- Windings. Electric inductors -- Design and construction -- Mathematical models. Electric current converters -- Design and construction -- Mathematical models. Energy dissipation -- Mathematical models.
Magnetic components for high-frequency power conversion applications can have significant losses that compromise the performance of the converter. In particular, winding losses can be large due to high-frequency effects that are difficult to model...
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Production of fuel ethanol from cellulosic materials is a potentially attractive way to meet sustainability, energy security, and environmental goals. However, the high cost of processing using current technology has thus far prevented...
Loss processes greatly impact the dynamics of the Earth's radiation belts. In 1996, a balloon-borne germanium detector flown over Kiruna, Sweden detected the first terrestrial X-rays with energies on the order of 1 MeV. The spectrum for these...
I. Markovnikov-Selective Hydrothiolation of Styrenes: Application to the Synthesis of Stereodefined Olefins There have been few reports in the literature describing Lewis Acid-catalyzed hydrothiolations that furnish Markovnikov-selective Câ€“S bond...
Little behavioral research, and less neural work, has examined how we process quantities like negative numbers, which are worth less than nothing and yet have value. The goal of this dissertation was to determine whether negative number processing...
The previously synthesized 3,4-dibromo-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one has been shown to be a very versatile building block for the synthesis of complex natural product structures. This key building block has been made in both...
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Clinical medicine -- Decision making -- Mathematical models. ; Diagnosis Laboratory. ; Medical screening -- Mathematical models. ; Osteoporosis -- Diagnosis. ; Mycobacterial diseases -- Diagnosis.
This dissertation focuses on the use of decision analysis to study the optimal use of medical tests. The classic threshold model of clinical decision making provides methodological background and motivation for the dissertation. In this model,...
Medical care -- Decision making. Health attitudes. Prostate -- Cancer -- Treatment -- Decision making. Prostate -- Cancer -- Patients -- Attitudes. Uncertainty. Video recording in medicine.
This dissertation used two studies to evaluate the appropriateness of a theoretical model exploring the relationships between screening/treatment beliefs and intending to be screened or treated for prostate cancer (P-CA). Study One examined...
In this work we investigate the quantum dynamics of three different configurations of nonlinear cavity systems. We begin by carrying out a quantum analysis of a dc superconducting quantum interference device (SQUID) mechanical displacement detector...
Cellulase -- Biotechnology. ; Hydrolysis. ; Paper industry -- Technological innovations. ; Biomass energy -- Economic aspects. ; Saccharomyces cerevisiae -- Genetics. ; Enzymes -- Industrial applications.
Paper sludge is the largest solid waste stream produced by pulp and paper industry, and is also an attractive feedstock for emergent technologies based on processing of cellulosic biomass featuring enzymatic hydrolysis. This study focuses on...
This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
Medicine -- Study and teaching -- Audio-visual aids. ; Communication -- Audio-visual aids. ; Medical history taking. ; Physician and patient. ; Psychometrics.
The Patient Video Interview (PVI) is an instrument designed to assess communication skills in medical education that overcomes some of the drawbacks of other assessment methods. Three studies were conducted to: (a) determine a measurement system...
Ice mechanics. Compressibility. Fracture mechanics. Strains and stresses. Brittleness.
This work describes the effect of triaxial compressive confinement on the strength of columnar S2 ice loaded under conditions leading to brittle failure. Cubes of columnar S2 ice were tested at -10 Â°C under triaxial (proportional) loading where...
I investigate the kinematics and space densities of the local cataclysmic variable (CV) population. CVs are close binary star systems composed of a white dwarf that accretes matter from a less compact companion star in Roche lobe overflow....
The thesis is dedicated to the understanding and characterization of brittle compressive fracture of columnar S2 ice. The work quantifies the strength of fresh-water S2 ice and investigates its characteristic brittle failure modes under biaxial...
This thesis contains some results concerning groupoid dynamical systems and crossed products. We introduce the notion of a proper groupoid dynamical system and of its generalized fixed point algebra. We show that our notion of proper groupoid...
Proteins, the basic structural and functional building blocks of cellular machinery, evolve under significant constraint. Evolutionary pressures limit the acceptable variation and covariation of amino acids in a protein. As such, these evolutionary...
Topological graph theory. Aperiodicity. Paths and cycles (Graph theory)
The condition ""every cycle has an entry"" first appeared in the literature in Kumjian, Pask, and Raeburn's paper on Cuntz-Krieger algebras of directed graphs, where it was called Condition (L). It provides a necessary condition for simplicity of...