Magnetic nanoparticles are promising candidates for use in biomedical applications as remote sensors of biophysical properties, thermal therapy agents, and detectors of specific biomolecules. Many approaches have been used to model magnetic...
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
PDZ domains are protein:protein interaction domains that serve as molecular scaffolds, especially in the case of specialized cellular environments like polarized airway epithelial cells of the human lung. Historically the domains have been thought...
Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
The new APM South Equatorial Strip Catalog $({-}17\sp\circ.5<\delta<2\sp\circ.5)$ is used to select a sample of early-type galaxies in three directions: (1) 15h10-16h10; (2) 20h30-21h50; (3) 00h10-01h30. The distances and peculiar motions of...
Evolutionary Computation (EC) is one of the most advanced computational techniques. It has been frequently and successfully used to find good solutions to many complicated optimization problems with limited computational resources. EC is the...
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Breast -- Cancer -- Diagnosis. ; Near infrared reflectance spectroscopy. ; Image processing -- Digital techniques.
Near-infrared (NIR) light has the potential to be used as a non-invasive means of diagnostic imaging within the human breast. Due to the diffusive nature of light in tissue, computational model-based methods are required for functional imaging...
For a long-lived metastable system, the decay of the survival probability is typically exponential. However, deviations are known to exist at short times (the quantum Zeno effect) and at long times (algebraic tails in classical hydrodynamic...
The efficacy of many chemotherapeutic agents can be attenuated by expression of the anti-apoptotic proteins Bcl-2, Bcl-X and Mcl-1. When ML-1 leukemia cells are incubated with vinblastine, they rapidly upregulate Mcl-1. Suppression of Mcl-1 with...
Hypervelocity stars are stars ejected from the center of the Milky Way, never to return. Since first discovered in 2005, hypervelocity stars have greatly increased our understanding of the kinematics and dynamics at the Galactic Center. In this...
Third Conn. Lake Dam about 1924, Uppermost dam on the Conn. River abt. 2191 the Whole width of the Conn River shows in front of the seated figure FS Page
1957; First row (l to r) P Carnell, EL Abt, JW Morgan, RH DeVoto, J Allen, WD King, TE Healy, AL Hickerson, CA Peyser, RR Fawcett, YS Chae, LA Reid, HW Holt Second row (l to r) Prof Curtis, Mr Johnson, Mr Goldthwaite, Prof Stearns, Mr Thorpe, Prof...