This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
The new APM South Equatorial Strip Catalog $({-}17\sp\circ.5<\delta<2\sp\circ.5)$ is used to select a sample of early-type galaxies in three directions: (1) 15h10-16h10; (2) 20h30-21h50; (3) 00h10-01h30. The distances and peculiar motions of...
This dissertation examines the behavioral and physiological adaptations employed by modern humans to subsist in tropical rainforests. I employ various theoretical and methodological approaches to test hypotheses using empirical data from African...
Modern distributed systems scatter sensors, storage, and computation throughout the environment. Ideally these devices communicate and share resources, but there is seldom motivation for a device''s owner to yield control to another user. We...
This thesis is divided into 2 parts. In the first part of the thesis, we describe a software based approach to speeding up the Magnetic Resonance Imaging modality. In the second part of the thesis, we describe Significance Tree Quantization, which...
Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
In this thesis I present analyses of optical and X-ray data of early-type galaxies in nearby rich clusters as part of the NOAO Fundamental Plane Survey. Spectroscopic parameters, including linestrengths and velocity dispersions are measured for...
Chlorinated ethenes are ubiquitous environmental pollutants of public concern due to their potential toxicity and carcinogenicity. Under appropriate conditions anaerobic bacteria mediate the dechlorination of perchloroethylene (a common dry...
Space and time in language. ; Space perception. ; Figure-ground perception. ; Psycholinguistics.
Across languages, there exists a relatively small number of spatial prepositions. These terms are used to express the infinite number of possible spatial locations of an unlimited number of different entities in the environment. Previous research...
The Maine Coastal Current (MCC) flows south-westward along the New England coast in the Gulf of Maine. Red tides, river-borne pollutants, and biological species are hypothesized to be transported by the MCC. The transport pathways, and their...
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and in early stages of atherogenesis. ACAT has been investigated as a pharmaceutical target, yet its active site(s) remain largely...
An interval order is an ordered set whose elements are in correspondence with a collection of intervals in a linearly ordered set, with disjoint intervals ordered by their relative position. The order complex of an ordered set is the simplicial...
Three-dimensional imaging in medicine -- Mathematical models. ; Stereoencephalotomy.
In the past, clinicians skilled at image-guided neurosurgery have relied solely on pre-operative scans for their navigational information. Often in the course of surgery, tissue is purposely retracted/resected or inadvertently moved resulting in a...
Friction severely limits performance in precise positioning systems. This thesis investigates one possible approach to counter friction related performance losses, friction cancellation. In this method a friction observer is used to estimate...
Spectral theory is the subfield of differential geometry which provided the solution to Kac''s famous question, "Can you hear the shape of a drum?" That is, can we use the Laplace spectrum of a manifold to draw conclusions about its geometry or...
Lowest order charged particle motion in the Earth''s magnetosphere can be explained using simple adiabatic theory. However, nonadiabatic theory is required to explain particle behavior in cases such as when the particle's gyroradius is large...
The retinoids exert potent growth and differentiation effects on normal, embryonic and neoplastic cells. Although retinoids are known to regulate gene transcription through activation of retinoid receptors, the direct target genes of retinoid...
Relativity (Physics). ; Anisotropy -- Mathematical models. ; Einstein field equations. ; Newtonian fluids. ; Astrophysics.
We study the effects of anisotropic pressure on the properties of spherically symmetric, gravitationally bound spheres. We consider the full general-relativistic and Newtonian treatment of this problem and obtain exact solutions for various forms...