Dartmouth Digital Library Program

Local hyperthermia and nanoparticle targeting for cancer immunotherapy / by Seiko Toraya Brown.
Local hyperthermia treatment for cancer has been used clinically in combination with and to enhance the efficacy of traditional treatments such as chemotherapy and radiation. In association with recent understanding of the importance of stimulating...
Dartmouth Dissertations

Conformationally restricted bis(9-aminoacridine)s : a chemical and biological study
Acridine.
A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
Dartmouth Dissertations

Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations

Structural, stratigraphic, and thermo-chronological evolution of Trinidad.
Geochronometry -- Trinidad and Tobago -- Trinidad. ; Geology Structural -- Trinidad and Tobago -- Trinidad. ; Geology.
Dartmouth Dissertations

Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

Development of a ruby fluorescence-based surface probe of tribological processes.
Plastics -- Testing. ; Fluorescent probes. ; Temperature measuring instruments. ; Tribology. ; Polytef -- Thermal properties. ; Nylon -- Thermal properties.
This research has established feasibility of surface temperature characterization using ruby fluorescence. Study was performed in pin-on-disk geometry, with balls made of different plastics sliding against the sapphire disk. Fluorescence signal was...
Dartmouth Dissertations

Statistical methods for gene set annotation optimization unsupervised gene set testing and independent gene set filtering / by Hildreth Robert Frost.
Gene set testing has become a critical tool for interpreting the results of high-throughput genomic experiments. Despite the development of robust statistical methods and extensive gene set collections, however, the results from gene set testing...
Dartmouth Dissertations

Sensing eye position.
Saccadic eye movements. ; Eye -- Movements. ; Visual perception -- Physiological aspects. ; Senses and sensation.
The oculomotor system needs up-to-date information about eye position in order to make accurate saccades to stimuli in the environment. This thesis investigated how well the oculomotor system uses information about eye position to make a variety of...
Dartmouth Dissertations

Regulation of matrix metalloproteinase gene expression by a synthetic rexinoid.
Metalloproteinases -- Inhibitors -- Mechanism of action. Collagenases -- Inhibitors -- Mechanism of action. Receptor-ligand complexes. Extracellular matrix proteins. Matrix Metalloproteinases.
The irreversible destruction of the tissues that comprise synovial joints is the hallmark of both rheumatoid arthritis and osteoarthritis. In both diseases, inflammatory cytokines, such as interleukin-1β, stimulate the production of matrix...
Dartmouth Dissertations

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