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    • DNA damage-induced cell cycle checkpoints as a target for cancer therapy.

    • DNA damage-induced cell cycle checkpoints as a target for cancer therapy.
    • Cancer cells -- Proliferation -- Molecular aspects. Biological control systems. Cancer cells -- Growth -- Regulation. Breast -- Cancer -- Genetic aspects. p53 protein. Cell cycle. DNA damage. Cellular signal transduction. Carcinogenesis --...
    • Cells respond to DNA damage by activating signal transduction pathways that cause cell cycle arrest at checkpoints in G 1 , S, or G 2 phases of the cell cycle; this allows time for repair of damaged DNA. The G 1 checkpoint is dependent upon the...

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