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- A novel region in the collagenase promoter is involved in transcriptional activation and repression.
- Collagenases. ; DNA-protein interactions.
- Dartmouth Dissertations
- The finger cuff.
- Blood pressure -- Measurement.
- Dartmouth Dissertations
- The state of surface bound water on lysozyme.
- Water. ; Molecular dynamics. ; Lysozyme.
- Dartmouth Dissertations
- Multimodal electroencephalography and near-infrared spectroscopy neuroimaging measurement and analysis / by Paolo Giacometti
- This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
- Dartmouth Dissertations
- The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
- Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
- Dartmouth Dissertations
- The interleukin 2 receptor: functional consequences of its biomolecular structure.
- T cells -- Receptors. ; Interleukin-2.
- Dartmouth Dissertations
- Using theory to predict phase behaviour in liquids, copolymer melts, and ultrathin polymer films / by Nicholas B. Tito.
- Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
- Dartmouth Dissertations
- Dependence of snow thermal and electrical conductiveness on microstructure.
- Snow -- Thermal properties. ; Snow -- Electric properties. ; Microstructure.
- Dartmouth Dissertations
- Some results in the partition calculus.
- Partitions (Mathematics).
- Dartmouth Dissertations
- Feasibility testing for magneto-optic ring cellular automata.
- Cellular automata. Magnetooptical devices -- Testing. Thin film devices -- Testing.
- The feasibility of a magnetic computation system was tested that consists of arranging thin film micromagnetic ring structures. Each ring is magnetized in a circular, vortex state in either the clockwise (CW) or counterclockwise (CCW) directions,...
- Dartmouth Dissertations
- Efficient parallel algorithms for closest point problems.
- Computer algorithms. ; Parallel processing (Electronic computers). ; Geometry -- Data processing.
- Dartmouth Dissertations
- Cytoskeletal reorganization in B lymphocyte activation.
- Lymphocyte transformation.
- Dartmouth Dissertations
- Biochemical characterization of recombinant acyl coenzyme A:cholesterol acyltransferase expressed in insect Sf9 cell.
- Acyltransferases. ; Enzymatic analysis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation. ; Genetic recombination.
- Dartmouth Dissertations
- Extensions of graph C*-algebras.
- C*-algebras. ; Directed graphs. ; Functor theory.
- Dartmouth Dissertations
- Dielectric relaxation and local chain motion in concentrated polymer solutions.
- Polymers.
- Dartmouth Dissertations
- Reduction of the carcinogen chromate by cellular components and model compounds.
- Chromate. ; Mitochondria. ; Carcinogens.
- Dartmouth Dissertations
- Line closure and the Steinitz exchange axiom: Hartmanis matroids.
- Matroids. ; Axioms.
- Dartmouth Dissertations
- The role of CD40 and its ligand in transplant tolerance.
- CD antigens. T cells -- Receptors. Receptor-ligand complexes. Transplantation immunology. Immunological tolerance -- Molecular aspects. Antigens
- Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
- Dartmouth Dissertations
- Cell-type specific expression of matrix metalloproteinase-1 (MMP-1).
- Metalloproteinases -- Genetic aspects. ; Metalloproteinases -- Pathophysiology. ; Collagenases -- Genetic aspects. ; Collagenases -- Pathophysiology. ; Extracellular matrix proteins.
- Dartmouth Dissertations
- Identification of two small peptide products of translocation independent signal peptidase cleavage on bovine preprolaction.
- Peptides.
- Dartmouth Dissertations
- Extending the Ihara-Selberg zeta function to hypergraphs.
- Hypergraphs. Functions
- In the late 1960s, Ihara began work that led to the Ihara zeta function, a zeta function which is defined on a finite graph. This function is an interesting graph invariant which gives information on expansion properties of the graph. It also...
- Dartmouth Dissertations
- Chimeric NKG2D receptor expressing T cells as immunotherapy for cancer.
- T cells -- Receptors. Killer cells. Cell-mediated cytotoxicity. Cancer -- Immunotherapy.
- Despite advances in standard treatment options such as surgery, chemotherapy, and radiation, cancer remains the second leading cause of death in the United States. Moreover, many current therapies result in adverse effects. Therefore the...
- Dartmouth Dissertations
- Functions of prostacyclin in vascular and uterine smooth muscle.
- Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
- Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
- Dartmouth Dissertations
- Characterization and engineering of alginate lyases: assessing therapeutic revelance
- Chronic infection of the human airway by mucoid Pseudomonas aeruginosa is cited as the leading cause of death among Cystic Fibrosis patients. The persistent nature of these infections is linked to P. aeruginosa's ability to form protective biofilm...
- Dartmouth Dissertations
- Cemeteries
- Cemeteries
- Dartmouth College Photographic Files
- Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
- Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
- Dartmouth Dissertations
- Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
- Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
- Dartmouth Dissertations
- The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
- Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
- Dartmouth Dissertations
- Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
- Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
- Dartmouth Dissertations
- Metabolic engineering of catabolic product metabolism in thermophilic bacteria.
- Thermophilic bacteria -- Metabolism. Thermophilic bacteria -- Genetics. Thermophilic bacteria -- Biotechnology. Cells
- Metabolic engineering of the catabolic end-product metabolism of Thermoanaerobacterium saccharolyticum was initiated. T. saccharolyticum is an anaerobic, thermophilic bacterium that utilizes xylans and xylose, the second most prominent sugar after...
- Dartmouth Dissertations
- An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
- Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
- Dartmouth Dissertations
- Structural modifications of interleukin-2 with mutations at positions 47 and 65.
- Interleukin-2. Mutagenesis.
- Dartmouth Dissertations
- Role of genetic and endocrinological factors in the regulation of rat serum dopamine-beta-hydroxylase activity.
- Dopamine.
- Dartmouth Dissertations
- Photorearrangements of aryl halides.
- Photochemistry. Halides.
- Dartmouth Dissertations
- On methods for solving optimal stopping problems.
- Optimal stopping (Mathematical statistics).
- Dartmouth Dissertations
- Algorithmic problems arising in posets and permutations / by Shahrzad Haddadan
- Partially ordered sets and permutations are combinatorial structures having vast applications in theoretical computer science. In this thesis, we study various computational and algorithmic problems related to these structures. The first chapter of...
- Dartmouth Dissertations
- NPC1-mediated trafficking of intracellular cholesterol.
- Cholesterol -- Physiological transport. Cholesterol -- Genetic aspects. Cholesterol -- Metabolism. Genetic disorders -- Molecular aspects.
- Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
- Dartmouth Dissertations
- The wear resistance mechanism of particulate fillers in polytetrafluoroethylene-based polymer composites.
- Polytef. ; Mechanical wear. ; Fillers (Materials).
- Dartmouth Dissertations
- A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
- Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
- Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
- Dartmouth Dissertations
- Rabbit genomic clones for synovial fibroblast collagenase: tools for understanding connective tissue disease.
- Collagenases. ; Fibroblasts. ; Connective tissues -- Diseases -- Genetic aspects. ; Clone cells. ; Rabbits.
- Dartmouth Dissertations
- Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
- Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
- This thesis describes the synthetic study of two biologically related natural products: porphobilinogen (PBG) and cobyric acid. PBG is the key intermediate in the biosynthesis of all naturally occurring tetrapyrrolic 'pigments of life', including...
- Dartmouth Dissertations
- Locally minimal triangulations.
- Computer algorithms. ; Triangulation. ; Polygons. ; Computational geometry. ; Approximation theory -- Data processing. ; Mathematical optimization. ; Heuristic programming.
- Dartmouth Dissertations
- Bimolecular and intramolecular fluorescence quenching of an amine by a nitrile: Solution properties and chain structure of poly(1-olefin sulfone)s.
- Amines. ; Nitriles. ; Sulfones. ; Alkenes.
- Dartmouth Dissertations
- The mechanical and magnetic properties of FeAl.
- Iron-aluminum alloys -- Mechanical properties. ; Iron-aluminum alloys -- Magnetic properties.
- The effects of vacancies on the mechanical properties of FeAl single crystals and polycrystals have been investigated. Scanning calorimetric results indicate that vacancies in quenched Fe-40Al undergo rearrangement at ~550K, and then annihilate at...
- Dartmouth Dissertations
- Structure/function analyses of the murine -globin locus through trageted mutations.
- Globin genes -- Expression. Genetic markers. Genetic transcription -- Regulation. Mutation (Biology).
- Genes at the mammalian β-globin loci are arranged in the order of their developmental activation. Expression of individual genes at this locus is controlled by gene proximal and distal cis -regulatory elements. This thesis focused on the function...
- Dartmouth Dissertations
- Immunological and molecular characterization of a 62 kDa mitotic apparatus-associated protein important for mitotic progression.
- Mitosis. ; Nucleoproteins. ; Sea urchins -- Embryos. ; Molecular biology.
- A 62 kDa (p62) mitotic apparatus-associated protein has been shown to be important for the proper progression of mitosis in sea urchin embryos. The thesis project described here focuses on an immunological and a molecular characterization of p62....
- Dartmouth Dissertations
- Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
- RNA -- Metabolism. ; Herpes simplex virus.
- Dartmouth Dissertations
- Structural studies of Vibrio cholerae virulence gene regulators.
- Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
- Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
- Dartmouth Dissertations
- Expression of sporophytic and gametophytic storage proteins in the quillwort.
- Lycopodiaceae -- Spores. ; Club mosses -- Spores. ; Generations Alternating.
- Dartmouth Dissertations
- Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
- Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
- Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
- Dartmouth Dissertations

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