Computer input-output equipment. ; Computational grids (Computer systems). ; High performance computing. ; Electronic data processing -- Distributed processing.
High-performance computing increasingly occurs on computational grids composed of heterogeneous and geographically distributed systems of computers, networks, and storage devices that collectively act as a single virtual computer. A key challenge...
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
Whistler-mode chorus waves have recently drawn tremendous attention as an important mechanism for controlling the energetic electron flux in Earth’s radiation belt. This dissertation aims to answer questions about whistler-mode chorus waves, such...
Calanus finmarchicus -- Georges Bank. ; Calanus finmarchicus -- Maine Gulf of. ; Calanus finmarchicus -- North Atlantic Ocean.
Calanus finmarchicus, a kind of marine zooplankton, plays an important ecological role throughout the North Atlantic. Striking seasonal variations exist in its abundance and distribution in the Gulf of Maine/Georges Bank region. On the Bank in...
Multimedia systems -- Mathematical models. ; Information storage and retrieval systems. ; Machinery -- Alignment.
This thesis introduces multiple media correlation, a new technology for the automatic alignment of multiple media objects such as text, audio, and video. This research began with the question: what can be learned when multiple multimedia components...
Coding theory. Characters of groups. Error-correcting codes (Information theory). Polynomials.
We introduce vector-valued character theory, a higher dimensional generalization of character theory. We then use vector-valued characters to extend the MacWilliams equivalence theorem for linear codes to a class of additive codes, called...
Community mental health services -- Decision making. Mentally ill -- Care -- Decision making. Psychotherapist and patient.
Background. Electronic decision support systems (EDSS) using a shared decision making framework may be a new technology to facilitate service planning in public sector mental health care. The case management context is a ripe testing ground for...
Experimental and theoretical aspects of macroscopic and mesoscopic elastic instability are investigated in this thesis. For the theoretical investigations we utilize a Lagrangian formulation of nonlinear continuum elasticity theory, the novel...
Muscle proteins. Myosin -- Structure-activity relationships. Kinesin -- Structure-activity relationships. Mechanism of action (Biochemistry). Molecular Motor Proteins.
Protein motors, such as kinesin and myosin, use chemical energy in the form of ATP to physically move along filaments and perform complex mechanical tasks in the cell, such as intracellular transport, cell division and muscle contraction. Myosin...
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Study 1 This systematic review aimed to synthesize the emerging body of work on the impact of employment, with a focus on prospective cohort studies. Researchers identified relevant studies for review via PubMed, expert referral, and reference...
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Quantum wires and dots can be created by patterning inhomogeneous strain on semiconductor quantum wells. I have used laser spectroscopic methods to study the carrier transfer from the host quantum well to quantum wires and dots. For quantum dot...
ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
This study presents δ18O analyses of garnets microsampled by laser fluorination from two localities in the deep seated, Barrovian metamorphic terrane of eastern Vermont. The broad goals of the research were to constrain further the amount,...
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...