This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Earth's high latitude ionosphere, highly disturbed by particle and energy inputs and associated aurora, is the stage for plasma wave activity across a wide range of frequencies. These waves often exhibit strikingly distinct time-frequency structure...
The auroral zone is a rich source of natural radio emissions that can be observed in space and at ground-level. By studying these waves, scientists can gain insight into the plasma processes that generate them and use the near-Earth space...
Part I. A photoprecursor for difluorocarbene . The goal of this research was to develop a more practical and efficient photoprecursor for difluorocarbene. The first approach was concerned with the synthesis of 4,4-difluoropyrazoline-3,5-dione ( 5...
Microelectronics -- Design and construction. ; Micromachining. ; Strains and stresses. ; Silicon compounds.
This dissertation presents the use and extension of capabilities of surface machining technology, utilizing stress engineering between polysilicon and silicon nitride layers to build three-dimensional microstructures. A new theory and experimental...
A method for the reconstruction of a spectrum of mechanical properties from phase-contrast, MR displacement data is developed and implemented via the finite element method. To overcome the significant computational load associated with...
Experimental and theoretical aspects of macroscopic and mesoscopic elastic instability are investigated in this thesis. For the theoretical investigations we utilize a Lagrangian formulation of nonlinear continuum elasticity theory, the novel...
Diagnostic imaging -- Mathematics. Expectation-maximization algorithms. Imaging systems in medicine -- Mathematics.
We have developed a general-purpose registration algorithm for medical images and volumes. The transformation between images is modeled as locally affine but globally smooth, and explicitly accounts for local and global variations in image...
Oligomers -- Structure -- Mathematical models. Nuclear magnetic resonance spectroscopy.
Medical Term: Nuclear Magnetic Resonance, Biomolecular.
Protein complexes play vital roles in the fundamental processes of life. In particular, homo-oligomers are involved in cell signaling, regulation, and transport. To make detailed studies of these symmetric proteins, they need to be discovered, and...
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
This thesis constitutes the first steps in the author's program to investigate the question of when a homotopy of 2-cocycles ω = {ω[subscript t]}[subscript t∊[0,1]] on a locally compact Hausdorff groupoid Ɠ induces an isomorphism of the...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
Robots -- Control systems -- Design and construction. Mobile robots. Robots -- Dynamics.
This thesis examines the issues of vehicle and information dynamics in the control of a multi-robot system using a radial-basis potential function controller. Distributed control of multi-robot systems requires each robot to communicate state...
Wnt/[beta]-catenin signaling directs metazoan development and is aberrantly activated in many cancers; however, effective inhibitors to treat Wnt-driven cancers have long been elusive. Following the recent discovery that the ADPribose polymerase...
This thesis investigates a notion of Turing reducibility introduced by Winkler [8] that is total on all computably enumerable oracles. Groszek and Weber show in [7] that this is a new notion of reducibility and it is not transitive. They give su...
The Wnt/β-catenin signaling pathway controls numerous biological processes from embryogenesis to adult homeostasis; aberrant Wnt signaling underlies a wide range of human diseases. In the absence of Wnt stimulation, a multiprotein “destruction...
We study motion planning problems, finding trajectories that connect two configurations of a system, from two different perspectives: optimality and survivability. For the problem of finding optimal trajectories, we provide a model in which the...
In this thesis I present analyses of optical and X-ray data of early-type galaxies in nearby rich clusters as part of the NOAO Fundamental Plane Survey. Spectroscopic parameters, including linestrengths and velocity dispersions are measured for...