Dartmouth Digital Library Program

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Access control in and for the real world / by Sara Sinclair.
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
Dartmouth Dissertations

Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
Dartmouth Dissertations

Habitat selection in the American redstart (Setophaga ruticilla): the importance of early successional habitat and the role of landscape change in population declines.
Wood warblers -- Habitat. Wood warblers -- Effect of habitat modification on. Forest ecology -- New Hampshire. Animal populations -- Mathematical models.
Dartmouth Dissertations

Functional studies of human IgG Fc receptors.
Immunoglobulin G. Immunoglobulins.
Dartmouth Dissertations

Direct experimental investigation of the electron distribution function in a magnetized plasma.
Plasma dynamics. Electrons.
Dartmouth Dissertations

Treatment planning software for the Dartmouth IMAAH system
Cancer -- Radiotherapy -- Computer programs; Microwave antennas -- Physiological effect -- Computer programs
Dartmouth Dissertations

Activation of vascular endothelial cells in response to mineral fibers.
Asbestosis -- Pathophysiology. Asbestosis -- Molecular aspects. Pulmonary endothelium -- Genetic aspects. Endothelium -- Effect of asbestos on. Fibers -- Toxicology.
Dartmouth Dissertations

Structural modifications of interleukin-2 with mutations at positions 47 and 65.
Interleukin-2. Mutagenesis.
Dartmouth Dissertations

The transcriptional and post-transcriptional regulation of ecdysterone responsive genes.
Genetic regulation. Ecdysterone. Drosophila -- Genetics.
Dartmouth Dissertations

Apoptosis as a mechanism of cell death by anticancer agents.
Apoptosis. Antineoplastic agents.
Dartmouth Dissertations

Molecular mechanisms underlying the induction of neuronal Na channel expression by growth factors.
Neurons -- Growth -- Effect of growth factors on. Cell differentiation -- Molecular aspects. Developmental neurobiology.
Dartmouth Dissertations

Formal implementation of high-level languages for data-parallel programming
Parallel programming (Computer science). Programming languages (Electronic computers)
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

Parallel A.C. collisional conductivity of a plasma in a strong magnetic field
Plasma (Ionized gases) -- Conductivity
Dartmouth Dissertations

How we connect : neural mechanisms underpinning human social networks / by Carolyn M. Parkinson
One of the most distinctive aspects of humans as a species is our propensity to form complex social networks made up of intense, non-reproductive bonds with non-kin. Navigating these networks presents a considerable cognitive challenge that is...
Dartmouth Dissertations

Targeting kinetochore-microtubule stability affects chromosome segregation and tumor growth in mice / by Christopher D. Laucius
Chromosomal instability (CIN) is defined as a high rate of whole chromosome loss or gain and is a hallmark of many aneuploid solid tumors. CIN positively correlates with poor patient prognosis and chemotherapeutic resistance. The persistence of...
Dartmouth Dissertations

Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

NPC1-mediated trafficking of intracellular cholesterol.
Cholesterol -- Physiological transport. Cholesterol -- Genetic aspects. Cholesterol -- Metabolism. Genetic disorders -- Molecular aspects.
Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
Dartmouth Dissertations

Fibroblast gene expression in proliferative connective tissue disease.
Fibroblasts. ; Gene expression. ; Rheumatoid arthritis. ; Scleroderma (Disease).
Dartmouth Dissertations

Diffusion-weighted magnetic resonance imaging with high gradient fields.
Magnetic resonance imaging. ; Nuclear magnetic resonance.
Diffusion-weighted magnetic resonance imaging (MRI) provides unique contrast reflecting the translational motion of water in its microscopic environment. This imaging modality has been shown to highlight infarcted regions within minutes after an...
Dartmouth Dissertations

Rabbit genomic clones for synovial fibroblast collagenase: tools for understanding connective tissue disease.
Collagenases. ; Fibroblasts. ; Connective tissues -- Diseases -- Genetic aspects. ; Clone cells. ; Rabbits.
Dartmouth Dissertations

Uterine epithelial cell release of MIP3, TNF and TGF in response to Escherichia coli, Lactobicillus rhamnosus and pathogen associated molecular patterns (PAMP) and the influence of estradiol on cytokine release.
Epithelial cells. Estradiol -- Physiological effect. Tumor necrosis factor. Transforming growth factors-beta. Cytokines -- Pathophysiology. Escherichia coli. Lactobacillus rhamnosus. Uterus -- Pathophysiology.
The research presented in this thesis tested the hypothesis that uterine epithelial cells (UEC) are selectively responsive to bacteria and pathogen associated molecular patterns (PAMP) and that responses are influenced by estradiol (E 2 ). We...
Dartmouth Dissertations

Increases in specific forms of hepatic cytochrome P450s by ethanol and isopentanol: mechanism of the response.
Hepatotoxicology. ; Alcohol -- Toxicology. ; Cytochromes.
Dartmouth Dissertations

Characterization of the molecular mechanism by which arsenic and chromium alter inducible gene expression.
Arsenic -- Mechanism of action. ; Arsenic -- Toxicology. ; Chromium -- Mechanism of action. ; Chromium -- Toxicology. ; Gene expression.
Metals are ubiquitous in our environment. Through evolution, many biological processes have taken advantage of and have become dependent on specific metals for various biochemical functions. Metals can also be toxic to biological systems at...
Dartmouth Dissertations

Molecular characterization of human deoxyribonuclease II[alpha]: structural determinants of activity and therapeutic implications.
Deoxyribonucleases. ; Deoxyribonucleases -- Therapeutic use. ; Endonucleases -- Genetic aspects. ; Structure-activity relationships (Biochemistry). ; Pichia pastoris -- Cytogenetics. ; Cystic fibrosis -- Chemotherapy.
Dartmouth Dissertations

Microfabrication of magnetic components for high frequency DC-DC power conversion at high currents and low voltages.
DC-to-DC converters -- Design and construction. Electric inductors -- Design and construction. Thin film devices -- Design and construction. Microprocessors -- Power supply. Microfabrication. Transients (Dynamics).
Dartmouth Dissertations

Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
Dartmouth Dissertations

Dose dependent effects of sodium arsenite on NF-κB and interleukin-8 in bronchial epithelial cells.
Epithelial cells. ; NF-kappa B (DNA-binding protein). ; Interleukin-8. ; Arsenic compounds -- Physiological effect.
Dartmouth Dissertations

Fluorescence in situ hybridization studies of shared human chromosome 17 synteny in the Canidae.
Canidae -- Genome mapping. ; Human gene mapping. ; DNA probes. ; Hybridization. ; Linkage (Genetics).
Dartmouth Dissertations

Sounding rocket investigations of whistler, upper hybrid and Langmuir waves in the auroral ionosphere.
Auroras -- Alaska -- Observations. Ionospheric radio wave propagation -- Observations. Sounding rockets. Electromagnetic waves -- Observations. Whistlers (Radio meteorology) -- Alaska -- Observations.
In this thesis data from four sounding rocket experiments (PHAZE II, SIERRA, RACE and HIBAR) are used to explore the high and medium frequency waves seen in the auroral ionosphere. All rockets were launched into active aurora and carried both...
Dartmouth Dissertations

A study of charge transfer in cyanoanthracene/methyl-substituted benzene exciplexes.
Excited state chemistry. ; Photochemistry. ; Charge transfer.
Dartmouth Dissertations

The effect of estradiol-17ß and insulin on protein synthesis in primary monocultures of amphibian hepatocytes.
Proteins -- Synthesis. ; Insulin. ; Hormones. ; Amphibians.
Dartmouth Dissertations

Regulation of the rat cytochrome P4501A1 gene by polycyclic hydrocarbons and a dioxin congener.
Cytochrome P-450.
Dartmouth Dissertations

Modeling effects of magnetic field line curvature on transient proton belts.
Magnetosphere -- Mathematical models. ; Magnetic fields -- Mathematical models. ; Scattering (Physics) -- Mathematical models.
Lowest order charged particle motion in the Earth''s magnetosphere can be explained using simple adiabatic theory. However, nonadiabatic theory is required to explain particle behavior in cases such as when the particle's gyroradius is large...
Dartmouth Dissertations

Structure-function relations of cell membrane Ca efflux proteins.
Calcium-binding proteins. ; Renal tubular transport. ; Calcium -- Metabolism -- Regulation.
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Differential MCL1 phosphorylation occurs through distinct pathways.
Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Dartmouth Dissertations

Numerical and observational study of plasmaspheric ULF cavity resonance.
Plasmasphere. ; Magnetosphere. ; Magnetohydrodynamics. ; Magnetic resonance.
Dartmouth Dissertations

Influence of stromal cells on uterine epithelial cell function: direct and indirect effects of estradiol on epithelial cell integrity and cytokine release.
Uterus -- Physiology. Epithelial cells. Cellular control mechanisms. Estradiol -- Physiological effect. Cytokines -- Physiological effect. Hepatocyte growth factor. Transforming growth factors-beta. Tumor necrosis factor. Stromal Cells --...
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
Dartmouth Dissertations

Cytotoxic trigger molecules on human myeloid cells.
Cell-mediated cytotoxicity.
Dartmouth Dissertations

Biochemical characterization of T-cell growth factor (TCGF).
T cells. ; Cell proliferation.
Dartmouth Dissertations

The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
Dartmouth Dissertations

Mechanisms for chromium-induced signaling changes in pulmonary epithelial cells.
Chromium -- Pathophysiology. ; Lungs -- Pathophysiology. ; Epithelial cells. ; Cellular signal transduction. ; Transcription factors -- Pathophysiology. ; Protein kinases -- Pathophysiology. ; src-Family Kinases. ; Mitogen-Activated Protein Kinases.
Both human epidemiological and animal studies have associated inhalation of chromium(VI) (Cr(VI)) with increased incidence of pulmonary disease. This thesis examined the hypotheses that Cr(VI) activates cell signaling through kinase cascades and...
Dartmouth Dissertations

Cellular and molecular effects of chromium on the activity and expression of fibrinolytic proteins in epithelial cells.
Chromium -- Therapeutic use. ; Fibrinolysis. ; Epithelial cells. ; Pulmonary fibrosis.
Transition metals play critical roles in biological systems as essential components of metalloproteins and metalloenzymes, as diagnostic probes and pharmaceuticals, and in some instances, as sources of toxicity. Cellular concentrations vary...
Dartmouth Dissertations

Fine structure in auroral radio emissions.
Ionospheric radio wave propagation -- Observations. Hiss (Radio meteorology). Auroras -- Antarctica -- Observations.
A VersatIle Electromagnetic Waveform (VIEW) receiver was deployed at South Pole station in December 2002 in order to measure the fine structure of auroral radio emissions with high resolution and an unprecedented 500-1000 kHz bandwidth. Using this...
Dartmouth Dissertations