Dartmouth Digital Library Program

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Use of ionomics to identify genes that play a role in Arabidopsis metal homeostasis.
Arabidopsis -- Genetics. ; Cobalt -- Metabolism -- Genetic aspects. ; Iron -- Metabolism -- Genetic aspects. ; Nickel -- Metabolism -- Genetic aspects. ; Homeostasis.
Understanding trace element homeostasis in plants has a direct impact on global health. Much of the developing world suffers from nutrient deficiencies, and subsists on a plant based diet often lacking bioavailable nutrients like iron and zinc. At...
Dartmouth Dissertations

Syntrophin binds directly to members of the dystrophin family of proteins and exists as a heterogeneous family.
Protein binding. ; Muscle proteins -- Genetic aspects. ; Muscular dystrophy -- Genetic aspects.
Dartmouth Dissertations

A catalog of clusters to z [is less than or equal to] 1 from the Oxford Dartmouth Thirty Degree Survey.
Galaxies -- Clusters -- Mathematical models. Galaxies -- Formation -- Mathematical models. Galaxies -- Clusters -- Catalogs. Galaxies -- Spectra. Algorithms. Andromeda Galaxy.
A sample of 46 previously unidentified, intermediate- to high-redshift, near-infrared (NIR)-selected galaxy clusters have been discovered in the Andromeda catalog of the Oxford Dartmouth Thirty Degree Survey (ODTS). These clusters vary from low- to...
Dartmouth Dissertations

Neural representation of social knowledge in the medial prefrontal cortex.
Social perception -- Physiological aspects. ; Prefrontal cortex -- Physiology.
From the most minimal of person information, such as a photograph or a sentence, people are able to rapidly infer a multitude of complex personality traits. These social inferences are thought to rely upon cognitive representations of person...
Dartmouth Dissertations

Characterization of catalase in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics.
The Arabidopsis catalase gene family contains at least three genes, encoding subunits which combine in tetramers to form 7 detectable isozymes. Two of these genes are within 250 bp of each other at a single locus (CAT3/1) near the top of chromosome...
Dartmouth Dissertations

The effects of thyrotropin releasing hormone in the retrotrapezoid nucleus.
Thyrotropin releasing factor -- Physiological effect. ; Pons Varolii -- Physiology. ; Medulla oblongata -- Physiology. ; Respiration -- Regulation. ; Rats -- Respiration.
The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Dartmouth Dissertations

A spectroscopic investigation of chromium-thiolate complexes.
Chromium. Glutathione.
Dartmouth Dissertations

Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
Dartmouth Dissertations

The functional importance of the head direction signal for homing behavior / by William Nelson Butler
The rat limbic system contains head direction (HD) cells that fire according to heading in the horizontal plane. These HD cells are thought to provide animals with an internal compass to guide navigation. Previous work has found that HD cell tuning...
Dartmouth Dissertations

Identification and characterization of two mutants that affect Drosophila phototransduction.
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Reward and self-regulation in online digital environments.
Reward (Psychology). ; Self-control. ; Internet addiction -- Physiological aspects. ; Behavior Addictive -- pathophysiology.
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
Dartmouth Dissertations

Characterization of pathways and intermediates involved in CD40 signal transduction.
CD antigens. ; Cellular signal transduction. ; Immune response -- Regulation. ; Antigens CD40.
Dartmouth Dissertations

Molecular characterization of the circadian clock: locus frequency of neurospora crassa.
Neurospora crassa. ; Circadian rhythms. ; Mutation (Biology).
Dartmouth Dissertations

Isoperimetric numbers of certain Cayley graphs associated to PSL(2. Ζ[subscript n]).
Extremal problems (Mathematics). ; Cayley graphs. ; Riemann surfaces. ; Automorphisms.
We associate, to each positive integer n , a Cayley graph to the group PSL(2.Ζ[subscript n]). We then consider the isoperimetric numbers of these graphs. In chapter three we determine upper bounds for the isoperimetric number by a detailed...
Dartmouth Dissertations

Aneuploidy and chromosomal instability.
Aneuploidy. Chromosome abnormalities. Tumors -- Genetic aspects. Microtubules. Medical Term: Chromosomal Instability.
Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...
Dartmouth Dissertations

Ecological and evolutionary responses of tropical ectotherms to climate change / by Michael Latter Logan
Despite decades of research, the ability of scientists to predict the responses of ectothermic organisms to climate change remains remarkably low. Though an increasing number of models incorporate mechanistic relationships between environmental...
Dartmouth Dissertations

The employment of people with severe mental illness / by Alison E. Luciano.
Study 1 This systematic review aimed to synthesize the emerging body of work on the impact of employment, with a focus on prospective cohort studies. Researchers identified relevant studies for review via PubMed, expert referral, and reference...
Dartmouth Dissertations

Numerical and observational study of plasmaspheric ULF cavity resonance.
Plasmasphere. ; Magnetosphere. ; Magnetohydrodynamics. ; Magnetic resonance.
Dartmouth Dissertations

Image reconstruction optimization and quantification for image-guided luminescent tomography / by Robert William Holt.
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Dartmouth Dissertations

Terrain classification using proprioceptive sensors
Soils -- Classification.;""Engineering geology -- Mathematical models."";""Engineering geology -- Computer simulation."";""Mobile robots."";""Autonomous robots."";""Proprioception.""
Autonomous off-road navigation in unstructured, terrain can encounter mobility difficulties even when the surface that the vehicle is driving over is level and free from obstacles. Mobility challenges result from soil characteristics that prevent...
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

Critical structural features involved in the determination of agonist efficacy and trafficking of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor.
Glutamic acid -- Receptors. Ion channels -- Molecular aspects. Ligand binding (Biochemistry). Biological transport -- Regulation. Receptors.
AMPA receptors (AMPA-Rs) are glutamate-gated ion channels that mediate the majority of excitatory synaptic transmission in the brain. AMPA-Rs are generally found in vivo as hetero-tetramers made up of a combination of the GluR1-GluR4 subunits....
Dartmouth Dissertations

Eliciting patients' preferences for the intensity of preference-sensitive health care: An integrated research strategy.
Patients -- Decision making. Patients -- Attitudes. Motivation (Psychology) -- Social aspects. Preferences (Philosophy) Medical care -- Evaluation. Medical care -- Research -- Methodology. Medical care -- Decision making.
Statement of Problem Characterizing the public's preferential attitudes towards relatively more-/less-intense elective options in ""preference-sensitive"" health care situations is particularly relevant for the prioritization policies of...
Dartmouth Dissertations

Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
Dartmouth Dissertations

Hydrothermal pretreatment of cellulosic biomass for bioconversion to ethanol.
Alcohol as fuel. ; Cellulose -- Biotechnology. ; Hot water. ; Steam. ; Biomass energy.
Dartmouth Dissertations

Model systems for the study of carbocation-π interaction.
Carbocations -- Reactivity. ; Aromatic compounds -- Reactivity.
Interaction with aromatic π systems has become recognized as an important mode of stabilization of carbocation intermediates in biological reactions. To gain insight into such carbocation-π interactions, we have undertaken a study of...
Dartmouth Dissertations

A novel region in the collagenase promoter is involved in transcriptional activation and repression.
Collagenases. ; DNA-protein interactions.
Dartmouth Dissertations

Near-infrared spectroscopy of supernovae.
Supernovae -- Spectra. ; Infrared spectra.
Dartmouth Dissertations

Non-holomorphic cusp forms.
Cusp forms (Mathematics). ; Holomorphic functions.
Dartmouth Dissertations

Substrate recognition by the phenylalanine-adenylating domain of gramicidin synthetase, and redesign of nonribosomal peptide synthetases by modulation of substrate specificity.
Peptides -- Synthesis -- Mathematical models. ; Peptides -- Physiological effect. ; Peptides -- Biotechnology. ; Gramicidins. ; Immunospecificity. ; Site-specific mutagenesis. ; Binding sites (Biochemistry). ; Phenylalanine. ; Peptide Biosynthesis.
Non-ribosomal peptide synthetases (NRPS) are a family of enzymes that assemble a variety of pharmacologically interesting polypeptides from canonical and non-canonical amino acids. The identity and connectivity of the monomers in the final product...
Dartmouth Dissertations

Investigations of alkene-ozone kinetics using atmospheric-pressure static methods: ethene, 1-pentene, isoprene.
Alkenes. ; Ozone. ; Chemical kinetics. ; Atmospheric pressure -- Measurement.
Dartmouth Dissertations

Peer education in eating disorder prevention: a large scale longitudinal analysis of program effectiveness.
Eating disorders -- Prevention -- Longitudinal studies. ; Eating disorders -- Treatment. ; Peer counseling of students.
Eating disorders are a persistent problem for women on college campuses across the country, and peer education programs are one method that colleges have employed to address these concerns. A previous study found that peer education is actually...
Dartmouth Dissertations

Temperature effects on consumer-resource species interactions : integrating thermal physiology and community ecology / by Lauren Elizabeth Culler.
Climate change is altering the thermal environment for populations at all trophic levels and thus the response of any given population to warming can only be understood in the context of species interactions. Consumer-resource species interactions...
Dartmouth Dissertations

The effect of epileptiform activity and seizures during development on the prefrontal cortex and cognition / by Amanda Erin Hernan.
Epilepsy is the most common neurological disorder in children, with an incidence of 100 per 100,000 children per year. Recurrent seizures during this period in life are often distressing to the individual and the family, but arguably the most...
Dartmouth Dissertations

Game-theoretic approaches for adversarial multi-armed bandit scenarios.
We pose several adversarial variants of the multi-armed bandit scenario and propose new approaches for their play and analysis. Our casino patron seeks to discover information about an unknown system as a means to long-term payoff -- exploration...
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

Nonstigmatized individuals' reactions to the acknowledgment and valuation of a stigma by overweight individuals and physically disabled individuals.
Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
Dartmouth Dissertations

Assortativity and the robustness of gene regulatory networks / by Dov A. Pechenick.
Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...
Dartmouth Dissertations

Cytotoxic trigger molecules on human myeloid cells.
Cell-mediated cytotoxicity.
Dartmouth Dissertations

Late glacial and holocene fluctuations of local glaciers and the Greenland Ice Sheet eastern and western Greenland / by Laura B. Levy.
The Greenland Ice Sheet (GrIS) is responding sensitively to climate change and its meltwater has the potential to influence global sea level. Recently, large changes in the GrIS have occurred including increased velocities of outlet glaciers and...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

Sulfobetaines as novel inhibitors of squalene synthase. A model system for Δ4-3-ketosteroid isomerase.
Cholesterol -- Synthesis. Enzymes -- Inhibition. Isomerases -- Synthesis.
This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
Dartmouth Dissertations

The identification of molecular targets of synthetic oleanane triterpenoids
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
Dartmouth Dissertations

Microwave tomographic imaging using dielectric contrast in temperature and tissue content
Breast -- Cancer -- Tomography. ; Breast -- Cancer -- Imaging. ; Microwave imaging in medicine. ; Breast -- Electric properties. ; Breast Neoplasms -- diagnosis. ; Diagnostic Imaging -- methods.
Dartmouth Dissertations

The planar orotron: a metal grating coupled, millimeter wavelength radiation source.
Millimeter wave devices.
Dartmouth Dissertations

New technologies for constructing C-S and C-N bonds / by Markku Antti Savolainen
I. Markovnikov-Selective Hydrothiolation of Styrenes: Application to the Synthesis of Stereodefined Olefins There have been few reports in the literature describing Lewis Acid-catalyzed hydrothiolations that furnish Markovnikov-selective C–S bond...
Dartmouth Dissertations

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