Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
Topological graph theory. Aperiodicity. Paths and cycles (Graph theory)
The condition ""every cycle has an entry"" first appeared in the literature in Kumjian, Pask, and Raeburn's paper on Cuntz-Krieger algebras of directed graphs, where it was called Condition (L). It provides a necessary condition for simplicity of...
Phase transitions occur in such diverse and important systems as ferromagnets, liquid crystals and the early Universe. The dynamics of phase transitions such as these have been studied for decades, but the analytical models still need a great deal...
Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
In this thesis we study 1=k-geodesics, those closed geodesics that minimize on any subinterval of length L=k, where L is the length of the geodesic. These curves arise as critical points of the uniform energy, a function introduced in Morse theory...
There are no Vassiliev invariants of degree one for classical knots. A. Henrich proved the existence of a sequence of three Vassiliev invariants of degree one for virtual knots. The invariants get stronger and stronger, and the final invariant is...
I report the further characterization of an essential S. cerevisiae nucleoporin, RAT7/NUP159, shown previously to be involved in mRNA export. The Rat7p/Nup159p can be divided into three domains: an N-terminal domain, a central repeat domain, and a...
Biological conversion of biomass to fuels and chemicals offers recognized benefits. The absence of systematic methodologies for scaling up such conversion is an important issue related to realizing these benefits. This thesis addresses this scale...
Given graded C *-algebras A and B , we define the notion of an admissible pair ([straight phi], D ) for A and B . Associated to an admissible pair ([straight phi], D ) is an equivalence class of asymptotic morphisms from A to B . Under certain...
Optical tomography. Fluorescence. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models. Brain -- Diseases -- Diagnosis. Brain -- Magnetic resonance imaging.
Fluorescent molecules targeted to reveal information on tissue function have been used as research tools in ex vivo and subsurface characterization of diseased tissue for years. Exploiting this specificity for in vivo imaging through centimeters of...
For most cancers, the genetic mechanisms that predispose normal cells to neoplastic transformation and tumor cells to therapeutic eradication are poorly understood. High throughput genotyping technologies have allowed the rapid discovery of...
Public key infrastructure (Computer security). ; Computer networks -- Security measures. ; Operating systems (Computers). ; Microcomputers.
In 1976, Whitfield Diffie and Martin Hellman demonstrated how public key cryptography could enable secure information exchange between parties that do not share secrets. In order for public key cryptography to work in modern distributed...
The discovery of the Van Allen radiation belts in the 1958 was the first major discovery of the Space Age. There are two belts of energetic particles. The inner belt is very stable, but the outer belt is extremely variable, especially during...
I. (3 + 2) Cycloaddition Reactions of Oxyallyl Cationic Intermediates with Indoles Cyclopenta- and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 + 2) cycloaddition...