Dartmouth Digital Library Program

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The cognitive dynamics underlying decision-making : interactions between attention memory and reward in action control / by Kanghoon Jung.
A fundamental question in decision neuroscience is how cognitive processes underlying decision-making give rise to efficient decisions, especially in complex situations with multiple choice options, and each option consisting of multiple attributes...
Dartmouth Dissertations

Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Dartmouth Dissertations

Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
Dartmouth Dissertations

Affective decision-making in rhesus monkeys : reward order risk and the roles of the anterior insula and premotor cortex / by Eric R. Xu.
From deciding what to eat first or what stock to invest in, the order in which we prefer to experience events and the amount of risk we are willing to undertake are factors that influence our choices. However, the mechanisms underlying order and...
Dartmouth Dissertations

Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
Dartmouth Dissertations

From nonmetal- and metal-chalcogen nanoclusters to chalcogenide nanotubes.
Chalcogenides. Nanotubes. ; Nanostructured materials.
A double-acceleration stage linear time of flight mass spectrometer (TOF MS) with Nd/YAG laser ablation cluster source was designed and constructed for cluster production, study and deposition. Cumulenic polycarbons SC n S ( n = 2-27) were...
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

Determinants of the il-1β response to Pseudomonas aeruginosa / by Yash R. Patankar
IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...
Dartmouth Dissertations

Density functional theory study of transition metal doped chalcogenides / by Stefano Poggio
The main driving force behind the development of computers was the attempt to solve problems that would otherwise require a large amount of time to be solved. Despite the technological development that has made computers ubiquitous in daily lives,...
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Photoconductivity of optical fiber preforms.
Optical fibers -- Measurement. ; Photoconductivity -- Measurement. ; Second harmonic generation.
Dartmouth Dissertations

Memory and the resting brain.
Memory -- Physiological aspects. Hippocampus (Brain) -- Physiology. Perceptual-motor processes. Brain -- Variation.
Dartmouth Dissertations

Targeting G1 cyclins in cancer chemoprevention.
Bronchi -- Cancer -- Chemoprevention. ; Cyclins. ; Retinoids -- Therapeutic use. ; Cellular control mechanisms. ; G1 Phase.
Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer treatment and chemoprevention. There is a need for an in-depth understanding of the mechanisms that account for retinoid response or resistance in lung cancer...
Dartmouth Dissertations

Theoretical study of carbon-heteroatom clusters: Theoretical study and comparison of the intradiol and extradiol oxidation of catechol.
Catechol -- Biodegradation. Glycols. Oxidation. Carbon compounds -- Mathematical models.
Part 1 . A computational study targeting the lowest energy structure, electronic state and physical properties of small carbon clusters containing one or two heteroatoms has been done. The structural properties sought included whether the most...
Dartmouth Dissertations

Designing treatment individualization in photodynamic therapy to compensate for pharmacokinetic variability.
Photochemotherapy. Photosensitizing compounds -- Therapeutic use. Pharmacokinetics. Drugs -- Physiological effect.
The main theme of this thesis is to investigate the origins of photosensitizer pharmacokinetic variability, how this pharmacokinetic variation affects photodynamic therapy (PDT), and to search for innovative strategies to reduce the...
Dartmouth Dissertations

Electron transfer reaction in solution: initial charge separation distance distribution and its impact on free ion formation.
Free radicals (Chemistry). ; Electron donor-acceptor complexes. ; Ions.
In this study, the initial charge separation distance and its impact on free radical ion (FRI) formation are investigated in detail. Transient photocurrent techniques together with other spectroscopic methods were used with a series of donors and...
Dartmouth Dissertations

Thermodynamic and spectroscopic studies of metal binding properties of histidine-rich peptides and proteins.
Histidine. ; Peptides -- Analysis. ; Proteins -- Analysis. ; Metal ions. ; Binding sites (Biochemistry) -- Thermodynamics. ; Macromolecules -- Spectra. ; Thermometric titration. ; Calorimetry. ; Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

Gas diffusivity and air permeability of the firn from cold polar sites.
Snow -- Permeability. ; Snow surveys -- Antarctica -- East Antarctica. ; Surfaces -- Areas and volumes. ; Gas flow. ; Porosity.
Recent field investigations of a megadunes region of East Antarctica provide evidence that differences in grain size, thermal conductivity, and permeability across a megadune are due to relative accumulation patterns in the absence of significant...
Dartmouth Dissertations

Analysis of intracellular ion homeostasis during apoptotic cell death.
Apoptosis. ; Endonucleases. ; Calcium ions. ; Magnesium ions. ; Hydrogen-ion concentration.
A hallmark of apoptosis is internucleosomal DNA fragmentation catalyzed by an endogenous endonuclease. Many laboratories have implicated the activation of Ca2+/Mg2+-dependent endonucleases or the acid-dependent deoxyribonucleases, (DNase II),...
Dartmouth Dissertations

A thermodynamic investigation of metal ions binding to metal trafficking proteins, peptides and small molecules using isothermal titration calorimetry.
Metal ions. Binding sites (Biochemistry) -- Thermodynamics. Metalloenzymes. Cellular control mechanisms. Thermometric titration. Calorimetry.
The chemistry of biology is complex and there is a great deal that is not understood. A fundamental understanding of biochemical reactions is important to aid in the identification of undiscovered reactions and is critical to fully appreciate the...
Dartmouth Dissertations

Does continuity matter?: measuring the quality of ambulatory care among chronically ill elders in the United States.
Older people -- Medical care -- United States -- Evaluation. Chronically ill -- Medical care -- United States -- Evaluation. Ambulatory medical care -- United States -- Evaluation.
Objective . To examine how continuity is related to quality measures for chronically ill elderly patients; to the specialty and caseload of the physicians they predominantly visit; and to the regional context of where their ambulatory care is...
Dartmouth Dissertations

Radical methodologies with indole and synthetic strategies towards the indole alkaloids, echitamine and prenostodione.
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
Dartmouth Dissertations

A thermodynamic study of essential and toxic metals binding to proteins, peptides and small molecules involved in detoxification, storage, and gene regulation.
Metals -- Physiological effect. Binding sites (Biochemistry) -- Thermodynamics. Thiols. Thermometric titration. Zinc. Metallothionein. Genetic transcription -- Regulation.
Bioinorganic chemistry, a discipline that bridges chemistry and biology, has become increasingly popular as new techniques and analytical methods have emerged to study metals in biological systems. One such technique that has become increasingly...
Dartmouth Dissertations

Regulation of apoptosis in the Caenorhabditis elegans nervous system.
Caenorhabditis elegans -- Genetics. Neurons. Apoptosis. Genetic transcription -- Regulation.
Most of the cells that die during the development of a C. elegans hermaphrodite do so within 30 min after being generated. In these cells, the pro-caspase proCED-3 is inherited from progenitors and the transcriptional upregulation of the BH3-only...
Dartmouth Dissertations

Cross-kingdom communication: The role of quorum sensing signals in Candida albicans and Pseudomonas aeruginosa interactions.
Pseudomonas aeruginosa -- Molecular genetics. Candida albicans. Pseudomonas aeruginosa infections. Plant-pathogen relationships. Cystic fibrosis -- Immunological aspects. Virulence (Microbiology) -- Molecular aspects. Medical Terms: Farnesol;...
The overall scope of my thesis project is to determine effects of farnesol, a secreted factor produced by C. albicans , on P. aeruginosa virulence. These two organisms are frequently found with one another in mixed infections and our lab has...
Dartmouth Dissertations

The chemistry of arsenic and mercury under post-combustion conditions.
Arsenic wastes -- Analysis. Mercury wastes -- Analysis. Coal -- Combustion -- By-products. Fly ash. Flue gases.
Coal combustion remains an important source of toxic metal emissions. Dilute concentrations and poor understanding of their chemistries hinders reduction of these emissions. This thesis examines the chemistry of the trace metals arsenic and mercury...
Dartmouth Dissertations

Cortical representations of hierarchical category learning / by Sergey Victor Fogelson
Current theories of visual category learning posit a representation of category rules and visual features that critically define those categories that are encoded separately and distributed throughout the cerebral cortex. Neuroimaging and...
Dartmouth Dissertations

Analysis of aberrant cell cycle regulation in pancreatic ductal adenocarcinoma uncovers novel thereapeutic approaches
Aberrant activation of cyclin D-Cdk4/6 is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly specific inhibitor for Cdk4 and Cdk6, exerted growth inhibitory effects on human PDAC cell lines....
Dartmouth Dissertations

Tennis Womens
Tennis Womens
Tennis Womens; late 1980's; Louie Crosier 372; from the Aegis
Dartmouth College Photographic Files

Hanover Businesses 4
Hanover Businesses 4
Bouchard 1961; 1) Music Store 2) LaCourse 6/82 DAM
Dartmouth College Photographic Files

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