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Distinct neuroimmune interactions in acute inflammatory pain and persistent neuropathic pain.
Pain -- Immunological aspects. ; Inflammation -- Immunological aspects. ; Nervous system -- Diseases -- Immunological aspects. ; Neuroimmunology.
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
Dartmouth Dissertations

The impact of sodium channel isoform expression on cerebellar Purkinje cell development.
Purkinje cells. Sodium channels -- Genetic aspects. Excitation (Physiology). Neurons -- Physiology. Cerebellum -- Physiology. Genetic regulation.
Voltage-dependent sodium channels (Na v ) are critical determinants of the ability of a neuron to generate and propagate action potentials. While a large family of Na v isoforms has been identified, the impact of specific isoforms on the electrical...
Dartmouth Dissertations

Synthesis and kinetic studies of a .delta.4-3-ketosteroid isomerase model.
Isomerases. Enzymes. ; Steroids.
Dartmouth Dissertations

Diffusion-weighted magnetic resonance imaging with high gradient fields.
Magnetic resonance imaging. ; Nuclear magnetic resonance.
Diffusion-weighted magnetic resonance imaging (MRI) provides unique contrast reflecting the translational motion of water in its microscopic environment. This imaging modality has been shown to highlight infarcted regions within minutes after an...
Dartmouth Dissertations

Light and circadian regulation in Neurospora crassa.
Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
Dartmouth Dissertations

Intramolecular general base catalysis of proton abstraction alpha to carbonyl groups.
Carbonyl compounds. ; Chemical kinetics.
Dartmouth Dissertations

Investigation of ER-Golgi membrane proteins influencing COPII tethering and fusion / by Indrani Mukherjee
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Dartmouth Dissertations

Investigation of Sec22p in ER to Golgi transport in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Membrane fusion. Biological transport -- Regulation. Cell membranes. Saccharomyces cerevisiae -- Cytology. Golgi apparatus. Endoplasmic reticulum.
Vesicle mediated intracellular transport through the secretory pathway requires the formation of transport vesicles from a donor compartment followed by vesicle tethering and fusion with an appropriate acceptor compartment. The anterograde...
Dartmouth Dissertations

5-azacytidine induces fetal hemoglobin by a cell signalling mechanism that is upstream of changes in differentiation kinetics and promoter hypomethylation.
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Dartmouth Dissertations

Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Dartmouth Dissertations

Local hyperthermia and nanoparticle targeting for cancer immunotherapy / by Seiko Toraya Brown.
Local hyperthermia treatment for cancer has been used clinically in combination with and to enhance the efficacy of traditional treatments such as chemotherapy and radiation. In association with recent understanding of the importance of stimulating...
Dartmouth Dissertations

Unraveling mechanisms underlying myeloid-derived suppressor cell orchestration of ovarian cancer progression
Suppressor cells -- Cellular immunity. -- Interleukin-10 -- Pathophysiology -- Ovaries -- Cancer -- Immunological aspects. -- Myeloid cells -- immunology -- Ovarian Neoplasms -- immunology.
Dartmouth Dissertations

Characterizing the impact of single nucleotide variation in breast cancer / by Kinjal Desai
Genome sequencing technology has enabled the identification of genetic variants that are linked with cancer phenotypes, whether these are somatically acquired mutations or common inherited single nucleotide polymorphisms (SNPs). Whereas coding...
Dartmouth Dissertations

Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations

Splice variation-specific cellular and biochemical function of the formin INF2
Formins are actin nucleators that modulate the nucleation and elongation of actin filaments. Formin homology 1 (FH1) and formin homology 2 (FH2) domains play a key role in formin-mediated actin dynamics. INF2 is a unique formin which can both...
Dartmouth Dissertations

Investigation of the influence of lipids in ER to Golgi transport.
Membrane proteins -- Physiological transport. Coated vesicles -- Physiology. Phospholipids -- Physiological effect. Inositol phosphates -- Physiological effect. Carrier proteins -- Molecular aspects. Golgi apparatus. Endoplasmic...
The secretory pathway in eukaryotic cells is responsible for the exocytic and endocytic pathways, as well as for the delivery of proteins and lipids from their sites of synthesis to the cell surface and the different compartments of the...
Dartmouth Dissertations

Role of NA[subscript v]1.1 in septo-hippocampal coordination of theta rhythm and spatial memory : implications for cognitive deficits in Dravet syndrome / by Alex C. Bender
In the nervous system, neuronal communication relies critically on the function of membrane ion channels. One of these is the voltage-gated sodium channel (VGSC), which is essential for the generation and propagation of action potentials in...
Dartmouth Dissertations

Experimental studies of fine-particle transport in turbulent flows
Sediment transport.;""Silt."";""Turbulence.""
Dartmouth Dissertations

Ionic and mechanical responses of the rat brain to acute dilutional hyponatremia.
Brain -- Physiology. ; Hyponatremia.; Rats.
Dartmouth Dissertations

The importance of p53-dependent transcriptional responses in the differentiation and curability of human embryonal carcinoma.
Testis -- Cancer -- Genetic aspects. p53 antioncogene -- Regulation. Embryonal tumors -- Pathophysiology. Germ cells -- Tumors -- Pathophysiology. Cisplatin -- Mechanism of action. Tretinoin. Testicular Neoplasms -- in children. Neoplasms
Dartmouth Dissertations

$Isolation and characterization of a cortical secretory vesicle membrane fraction.$
Isolation and characterization of a cortical secretory vesicle membrane fraction.
Cell membranes. ; Membrane fusion. ; Membrane proteins.
Dartmouth Dissertations

The role of microglia in morphine tolerance.
Microglia -- Effect of drugs on. Morphine -- Physiological effect. Purines -- Receptors. Drug tolerance. Cell culture -- Technique. Medical Term Receptors, Purinergic P2 -- physiology.
Chronic pain is a debilitating condition which exacts severe emotional, physical and economic tolls on the millions of people who suffer from it worldwide. Opioids are a mainstay of acute, postoperative and cancer pain therapy, however, their use...
Dartmouth Dissertations

Sodium borohydride: reactions in acidic media and synthesis of [1n] paracyclophanes.
Sodium borohydride. ; Boron compounds.
Dartmouth Dissertations

The role of Protein kinase C in FcαR and BCR trafficking to MHC class II-containing compartments and antigen presentation.
Protein kinase C. Antigen presenting cells. Antigens -- Receptors. T cells -- Receptors. Major histocompatibility complex -- Genetic aspects. CD4-Positive T-Lymphocytes -- immunology. Histocompatibility Antigens Class II -- immunology. Receptors
Activation of CD4 T cells to exogenous antigens requires the formation and surface display of antigen-derived peptide-MHC class II complexes by antigen presentation cells. Acquisition of peptide by MHC class II is much studied, but the rules and...
Dartmouth Dissertations

Hormonal and neurochemical determinants of sex differences in chronic radicular pain.
Radiculitis -- Endocrine aspects. Radiculitis -- Sex factors. Radiculitis -- Pathophysiology. Pain -- Sex factors. Progesterone -- Physiological effect. Cellular signal transduction. Neuregulin-1 -- physiology.
Chronic low back pain is a debilitating and devastating disease affecting millions of people worldwide. Considerable evidence indicates that there are sex-related differences in clinical and experimental pain sensitivity in men and women. Women...
Dartmouth Dissertations

Aneuploidy and chromosomal instability.
Aneuploidy. Chromosome abnormalities. Tumors -- Genetic aspects. Microtubules. Medical Term: Chromosomal Instability.
Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...
Dartmouth Dissertations

The role of glia in neuropathic pain: a journey into the tetrapartite synapse.
Neuroglia -- Effect of drugs on. Astrocytes. Opioids -- Physiological effect. Central nervous system -- Pathophysiology. Nerves
Neuropathic pain is a debilitating condition that affects millions of individuals worldwide. Unfortunately, opioids are only partially effective in treating neuropathic pain while entraining tolerance and a myriad of side effects from the high...
Dartmouth Dissertations

Investigation of Yip1p function in transport between the ER and the Golgi complex.
Membrane proteins -- Physiological transport. Carrier proteins. Biological transport -- Regulation. Saccharomyces cerevisiae -- Physiology. Saccharomyces cerevisiae -- Genetics. Endoplasmic reticulum. Golgi apparatus.
The eukaryotic secretory pathway delivers proteins and lipids to their correct destination in a regulated manner. Transport through the secretory pathway is mediated by vesicles or tubular elements that bud from donor compartments. These transport...
Dartmouth Dissertations

Synthetic studies on viridin class of furanosteroids.
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
Dartmouth Dissertations

Improved synthesis and functionalization of the viridin core skeleton
The furanosteroid class of compounds issues a siren call to both chemists and biologists alike -- the intriguing pentacyclic skeleton, densely packed and highly functionalized, continues to entice synthetic minds to develop new and elegant methods...
Dartmouth Dissertations

In vivo degradation in modern orthopaedic UHMWPE bearings and structural characterization of a novel alternative UHMWPE material / by Steven D. Reinitz.
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Dartmouth Dissertations

Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases.
Epistasis (Genetics) Protein-protein interactions -- Data processing. Proteomics -- Data processing. Diseases -- Risk factors -- Statistical methods. Chromosome polymorphism. Software measurement -- Evaluation. Computational biology -- Methodology.
The completion of the Human Genome Project in 2003 and the HapMap Project in 2005 has broadened the spectrum of genetic research tools that allow researchers to conduct genome-wide association studies (GWAS) for detecting genetic variants that...
Dartmouth Dissertations

Biochemical analysis of stimulus-secretion coupling in permeabilized mast cells.
Cellular signal transduction. ; Secretion. ; Mast cells.
Dartmouth Dissertations

New preparations of substituted (3H)-1,2-dithiole-3-thiones and investigations into the mechanism of their formation.
Dithiole -- Synthesis. ; Thiols -- Synthesis. ; Aliphatic compounds -- Synthesis.
This thesis describes a new synthesis of substituted (3H)-1,2-dithiole-3-thiones (dithiolethiones) from readily available starting materials. Dithiolethiones have a wide variety of industrial and pharmaceutical applications. These include use as...
Dartmouth Dissertations

Isolation and functional characterization of yeast vacuole snare complexes.
Membrane proteins -- Physiological transport. ; Plant proteins -- Physiological transport. ; Biological transport -- Regulation. ; Plant vacuoles. Saccharomyces cerevisiae -- Physiology.
Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Genetic screens and reconstituted biochemical assays have revealed that intracellular protein trafficking is mediated by a conserved mechanism of vesicle budding, transport,...
Dartmouth Dissertations

Analysis of inpatient surveillance data for automated classification of deterioration.
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Dartmouth Dissertations

The chemistry of arsenic and mercury under post-combustion conditions.
Arsenic wastes -- Analysis. Mercury wastes -- Analysis. Coal -- Combustion -- By-products. Fly ash. Flue gases.
Coal combustion remains an important source of toxic metal emissions. Dilute concentrations and poor understanding of their chemistries hinders reduction of these emissions. This thesis examines the chemistry of the trace metals arsenic and mercury...
Dartmouth Dissertations

Mechanisms of Rab- and Rab effector-dependent membrane tethering, docking, and fusion.
Membrane fusion. Membrane proteins -- Physiological transport. Yeast fungi -- Cytology. Medical Term Vacuoles -- metabolism. Cytoplasmic Vesicles -- metabolism rab GTP-Binding Proteins -- metabolism Proteolipids -- metabolism
Yeast vacuole fusion requires 4 SNAREs, the Rab GTPase Ypt7p, vacuolar lipids, the SNARE complex disassembly machinery Sec17p and Sec18p, and the heterohexameric HOPS complex. Vacuole fusion occurs in stages: cis-SNARE complexes (bound to one...
Dartmouth Dissertations

Biochemical and electrophysiological analysis of the interaction between sodium channel α and ß subunits.
Sodium channels -- Genetic aspects. ; Sodium channels -- Chemistry. ; Sodium channels -- Physiology. ; Ion channels -- Genetic aspects. ; Neurotoxic agents -- Physiological effect.
Dartmouth Dissertations

Measuring the seeds of thermal ion outflow / by Philip A. Fernandes
The ionosphere is the primary source for heavy ions which are ubiquitous in the terrestrial magnetosphere. Low-altitude energization in the auroral ionosphere results in bulk heating and transverse acceleration of ions, which begin to upwell and/or...
Dartmouth Dissertations

Apoptosis as a mechanism of cell death by anticancer agents.
Apoptosis. Antineoplastic agents.
Dartmouth Dissertations

Detection of hydrocarbons and hydrocarbon microseepage in the Bighorn Basin, Wyoming using isotopic, biogeochemical, and spectral reflectance techniques.
Hydrocarbons -- Secretion. Petroleum -- Geology -- Bighorn Basin (Mont. and Wyo.). Natural gas -- Geology -- Bighorn Basin (Mont. and Wyo.). Isotope geology -- Bighorn Basin (Mont. and Wyo.). Sagebrush -- Bighorn Basin (Mont. and Wyo.) -- Analysis....
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

Role of Erv14p in vesicle mediated protein transport from the endoplasmic reticulum to the Golgi in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Transport vesicles form at a donor compartment and fuse to an acceptor compartment mediate the movement of cargo proteins within eukaryotic cells from one subcellular compartment to another. COPII vesicles specifically provide the means of...
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

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