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- Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
- Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
- Dartmouth Dissertations
- The RNA binding landscape of the histone stem-loop binding protein / by Lionel (Lee) Brooks 3rd.
- RNA binding proteins are fundamental components of crucial biological processes in all domains of life. The development of techniques to study RNA binding protein complexes is, therefore, broadly impactful. I employed multiple genome-wide...
- Dartmouth Dissertations
- Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
- Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
- Dartmouth Dissertations
- Aligned hierarchies for sequential data / by Katherine M. Kinnaird.
- We present aligned hierarchies, a novel solution to the dimension reduction problem, representing high-dimensional and noisy sequential data as a low-dimensional object that encodes relevant information. In this thesis, we motivate our presentation...
- Dartmouth Dissertations
- Patient classification from fMRI brain activation patterns.
- Brain -- Magnetic resonance imaging. ; Brain mapping. Brain -- Localization of functions. ; Diagnostic imaging. ; Pattern perception. ; Patients -- Classification. ; Alzheimer's disease -- Diagnosis. ; Schizophrenia -- Diagnosis. ; Brain damage --...
- Earlier work has suggested that various neurological or neuropsychiatric disorders may result in characteristic spatial patterns in brain activation, potentially allowing their detection from maps of brain activity under different conditions....
- Dartmouth Dissertations
- Assessing communication skills in medical education: development of the patient video interview.
- Medicine -- Study and teaching -- Audio-visual aids. ; Communication -- Audio-visual aids. ; Medical history taking. ; Physician and patient. ; Psychometrics.
- The Patient Video Interview (PVI) is an instrument designed to assess communication skills in medical education that overcomes some of the drawbacks of other assessment methods. Three studies were conducted to: (a) determine a measurement system...
- Dartmouth Dissertations
- Thermodynamic Studies of Metal Interactions with Four Biomolecules Using Isothermal Titration Calorimetry / by Margaret C. Carpenter
- Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
- Dartmouth Dissertations
- The consequences of land-use on subsidies of stream insects to terrestrial consumers / by Ramsa Chaves-Ulloa
- The image of a child standing at the side of a creek and skipping stones across it exemplifies how we tend to mentally separate aquatic habitats from dry land. But there is a constant exchange of materials from land to streams, and vice-versa....
- Dartmouth Dissertations
- Thermodynamic studies of copper binding to azurin : development and application of a novel method to determine the reduction potential and reduction thermodynamics of metalloproteins / by Molly L. Croteau
- Cupredoxins, such as stellacyanin, plastocyanin, amicyanin, rusticyanin, and azurin perform electron transfer (ET) reactions with partner protein(s) in the cell. The role of the redox cofactor in these proteins is played by a copper ion, which...
- Dartmouth Dissertations
- High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
- Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
- Dartmouth Dissertations
- Cellular organization in syncytia : nuclear autonomy and cytosolic organization across kingdoms / by Samantha Elizabeth Roberts
- All cells must organize their cytoplasm in order to carry out functions properly and survive in different environments, and the requirement for organization is increased in large, multinucleate cells. It has long been known that membrane-bound...
- Dartmouth Dissertations
- Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
- Dendritic cells. Biological response modifiers. Immune response -- Regulation. T cells. CD antigens. Dendritic Cells -- Immunology. Receptors
- Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature...
- Dartmouth Dissertations
- Light and circadian regulation in Neurospora crassa.
- Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
- Dartmouth Dissertations
- Radial diffusion of radiation belt electrons in three dimensions.
- Van Allen radiation belts -- Mathematical models. Electrons -- Diffusion -- Mathematical models. Magnetohydrodynamic waves -- Mathematical models.
- It is becoming increasingly important to understand the dynamics of radiation belt energetic particles given their potentially hazardous effects on satellites and our ever-increasing dependence on those satellites. There is a need to determine...
- Dartmouth Dissertations
- Linking Atlantic salmon (Salmo salar) survival with their habitat using environmental tracers.
- Atlantic salmon -- Ecology. ; Atlantic salmon -- Habitat. ; Atlantic salmon -- Food. ; Radioactive tracers in ecology. ; Stable isotopes in ecological research. ; Strontium -- Isotopes -- Environmental aspects. ; Cesium -- Isotopes -- Environmental...
- Dartmouth Dissertations
- Sounding rocket investigations of whistler, upper hybrid and Langmuir waves in the auroral ionosphere.
- Auroras -- Alaska -- Observations. Ionospheric radio wave propagation -- Observations. Sounding rockets. Electromagnetic waves -- Observations. Whistlers (Radio meteorology) -- Alaska -- Observations.
- In this thesis data from four sounding rocket experiments (PHAZE II, SIERRA, RACE and HIBAR) are used to explore the high and medium frequency waves seen in the auroral ionosphere. All rockets were launched into active aurora and carried both...
- Dartmouth Dissertations
- Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
- RNA -- Metabolism. ; Herpes simplex virus.
- Dartmouth Dissertations
- Modeling of shocks in young and old supernova remnants.
- Supernova remnants. Shock waves -- Mathematical models. Interstellar matter.
- We present results from a modeling effort of simple shock phenomena in the Cygnus Loop and Cassiopeia A. Using multi-epoch MDM observations of a small, isolated cloud in the southwest region of the Cygnus Loop, we measure the velocity of the...
- Dartmouth Dissertations
- Synthesis of N-Hydroxyacetaminophen and studies on its in vitro decomposition.
- Acetanilide. ; Acetaminophen -- Physiological effect.
- Dartmouth Dissertations
- Near-infrared spectroscopy of supernovae.
- Supernovae -- Spectra. ; Infrared spectra.
- Dartmouth Dissertations
- Coupling of termination, 3' processing and mRNA export.
- Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
- Dartmouth Dissertations
- Three dimensional shape analysis with parametric surface modeling.
- Geometrical models -- Data processing. Three-dimensional display systems. Diagnostic imaging -- Mathematical models. Hippocampus (Brain) -- Imaging. Spherical harmonics. Computer vision -- Mathematical models. Computer algorithms.
- Shape modeling is an important area in computer vision and medical imaging. Shape models have proved valuable in the tasks of object representation, recognition, and classification. This thesis focuses on shape models of 3D surfaces extracted from...
- Dartmouth Dissertations
- Biochemical and electrophysiological analysis of the interaction between sodium channel α and ß subunits.
- Sodium channels -- Genetic aspects. ; Sodium channels -- Chemistry. ; Sodium channels -- Physiology. ; Ion channels -- Genetic aspects. ; Neurotoxic agents -- Physiological effect.
- Dartmouth Dissertations
- Gain experiments with a grating based free electron laser.
- Free electron lasers -- Experiments. Wave guides -- Design and construction. Diffraction gratings -- Experiments. Electron beams. Infrared sources.
- The far infrared region of the electromagnetic spectrum, 15-3000 Œºm in wavelength, has a paucity of narrow band laser sources. To address the issue of whether a grating based free electron laser could operate well as such a source, a grating...
- Dartmouth Dissertations
- Nonequilibrium dynamics of emergent field configurations.
- Nonequilibrium thermodynamics -- Mathematical models. Fluctuations (Physics) -- Mathematical models. Phase transformations (Statistical physics) -- Mathematical models. Configurations.
- The processes by which nonlinear physical systems approach thermal equilibrium is of great importance in many areas of science. Central to this is the mechanism by which energy is transferred between the many degrees of freedom comprising these...
- Dartmouth Dissertations
- The molecular evolution of the Drosophila neurogenic ectodermal enhancers.
- Drosophila -- Genetics. Transcription factors. DNA-protein interactions. Genetic transcription -- Regulation. Evolutionary genetics.
- The control of gene expression is central to developmental biology, pattern formation, and phenotypic evolution. Enhancers are a class of regulatory DNAs that control when and where genes are turned ON or OFF. This highly regulated process is...
- Dartmouth Dissertations
- Single cycle terahertz pulse propagation in water.
- Electromagnetic devices -- Design. Electromagnetic waves -- Transmission -- Measurement. Picosecond pulses. Water.
- Single cycle electromagnetic pulses have been difficult to experimentally generate and to theoretically analyze. With the recent development of terahertz systems based on near infrared femtosecond lasers it has become possible to perform single...
- Dartmouth Dissertations
- Impact of semen on mucosal transmission of HIV
- Semen is the major vector for sexual transmission of HIV worldwide, yet little is known about its role in modulating mucosal transmission of HIV. Understanding the impact of semen on mucosal transmission of HIV could open up novel means of...
- Dartmouth Dissertations
- Nuclear asynchrony and ploidy variation in the multinucleate fungus ashbya gossypii
- Classic studies demonstrated that when cells in different cell cycle phases are fused, nuclei cohabiting in a common cytoplasm synchronize their division cycles. Cytoplasmic factors, now known to be cyclin/cyclin dependent kinase (CDK) complexes,...
- Dartmouth Dissertations
- Alumni Gala dinner in Alumni Gym: Judith G. Grant;...
- 2004-12-03_alumni
- Dartmouth College Photographic Records
- 2010 Trips dinner for Class of 2014 trippees at th...
- Dartmouth College Photographic Records
- Annabel W. Seymour, Class of 2009, and Molly R. Bo...
- Dartmouth College Photographic Records
- Alumni: January 1998; Blunt Alumni Center; Alumni ...
- Dartmouth College Photographic Records
- Alumni: January 1998; Blunt Alumni Center; Alumni ...
- Dartmouth College Photographic Records
- Art: May 2000; Clement Hall; Students at work in t...
- Dartmouth College Photographic Records
- Students make musical instruments during a four-da...
- Dartmouth College Photographic Records
- Casque and Gauntlet 100th Anniversary 1987
- Casque and Gauntlet 100th Anniversary 1987
- Ed & Molly Sheu
- Dartmouth College Photographic Files
- 2011 Class Day Exercises, in Leverone Field House:...
- Dartmouth College Photographic Records
- Classroom: January 1998; Conference Room, Cummings...
- Dartmouth College Photographic Records
- Jim Yong Kim, President of the College, meets with...
- Dartmouth College Photographic Records
- announcement of Dr. Jim Yong Kim as the 17th Presi...
- Dartmouth College Photographic Records
- Jim Yong Kim, President of the College, meets with...
- Dartmouth College Photographic Records
- announcement of Dr. Jim Yong Kim as the 17th Presi...
- Dartmouth College Photographic Records
- left to right, Yangyang Liu, Class of 2009; Geoffr...
- Dartmouth College Photographic Records
- Barry P. Scherr, Ph.D., Provost, Mandel Family Pro...
- 2001-09-24_convocation
- Dartmouth College Photographic Records
- Barry P. Scherr, Ph.D., Provost, Mandel Family Pro...
- 2001-09-24_convocation
- Dartmouth College Photographic Records
- Barry P. Scherr, Ph.D., Provost, Mandel Family Pro...
- 2001-09-24_convocation
- Dartmouth College Photographic Records
- 2008 Convocation in Leede Arena: left to right, Ja...
- Dartmouth College Photographic Records
- 2008 Community Waste-Free Cookout, on Tuck Mall: S...
- Dartmouth College Photographic Records
- 2008 Convocation in Leede Arena: Molly R. Bode, Cl...
- Dartmouth College Photographic Records

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