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    • Cercle Francais

    • Cercle Francais
    • Cercle Francais
    • Cercle Francais 1917; 1. Derosier, J. E. '18; Defarrari, H. A. '17; Knowlton, A. H. '17; Dupuis, A. L. '17; Green, I. I. '17; Oppenheimer, R. J. '18; Towler, E. D. '17; 2. Halliday, R. '19; Mudgett, W. A. '18; Liscord, P. S. '18; Finlayson, D. L....
    • Novel inhibitors of MMP-1 and MMP-13 gene expression as potential therapies for arthritis.

    • Novel inhibitors of MMP-1 and MMP-13 gene expression as potential therapies for arthritis.
    • Collagenases -- Genetic aspects. Collagenases -- Pathophysiology. Metalloproteinases -- Genetic aspects. Metalloproteinases -- Pathophysiology. Transcription factors. Extracellular matrix proteins. Cartilage -- Diseases. Arthritis -- Genetic...
    • Matrix metalloproteinases (MMPs) are a family of endopeptidases that collectively degrade all components of the extracellular matrix (ECM) at neutral pH. During the progression of arthritis, MMPs mediate the degradation of cartilage, which consists...
    • The role of p38 MAP kinase in the regulation of mRNA stability.

    • The role of p38 MAP kinase in the regulation of mRNA stability.
    • Messenger RNA -- Metabolism. ; Mitogens. ; Thalidomide. ; Glucose -- Physiological transport. ; Mitogen-Activated Protein Kinases. ; MAP Kinase Signaling System. ; Protein processings Post-transcriptional. ; Hippel-Lindau Disease.
    • We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...
    • Hepatic T cells and MDSCs in TGF-ß1-deficient mice.

    • Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
    • Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
    • Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
    • IL-1 regulation of collagenase-3 (MMP-13) gene expression in chondrocytic cells.

    • IL-1 regulation of collagenase-3 (MMP-13) gene expression in chondrocytic cells.
    • Interleukin-1. ; Extracellular matrix proteins -- Metabolism. ; Cartilage cells -- Metabolism. ; Metalloproteinases -- Genetic aspects. ; Collagenases -- Genetic aspects. ; Genetic transcription -- Regulation. ; Chondrocytes
    • The matrix metalloproteinases (MMPs) are family of enzymes with a common domain structure that degrade extracellular matrix proteins; these enzymes are overexpressed in numerous diseases including cancer and arthritis. Collagenase-1, 2, 3 (MMP-1,...

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