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    • Modulation of CYPS: effect on acetaminophen hepatotoxicity.

    • Modulation of CYPS: effect on acetaminophen hepatotoxicity.
    • Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
    • Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
    • Mechanisms by which arsenite decreases CYP3A.

    • Mechanisms by which arsenite decreases CYP3A.
    • Cytochrome P-450 -- Pathophysiology. ; Cytochrome P-450 -- Genetics. ; Arsenic compounds -- Physiological effect. ; Liver cells.
    • Arsenic is implicated in numerous human pathologies, including cancer and several forms of liver disease. One contributing mechanism may involve alterations of CYP levels by arsenic. CYP3As are the most abundant CYP proteins in human liver and...

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