The central topic of the self has proven a vexing conundrum for philosophers and psychologists alike for centuries. Prior research suggests that the self is a powerful cognitive structure which biases attentional mechanisms in favor of apprehension...
Optical tomography. ; Near infrared spectroscopy. ; Image analysis -- Mathematical models. ; Imaging systems -- Image quality -- Mathematical models. ; Image reconstruction -- Mathematical models. ; Least squares. Breast -- Tomography.
Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber...
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Proper chromosome alignment and segregation depends on the formation and maintenance of a bipolar mitotic spindle with focused poles. It has been shown that microtubules are focused at spindle poles through the combined actions of centrosomes and a...
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
The transmissible spongiform encephalopathies (TSEs), also known as the prion diseases, are a unique group of fatal neurodegenerative diseases affecting humans and other mammals that have infectious, inherited and sporadic etiologies. A central...
Successful completion of the cell division cycle is critical for cellular duplication and survival. There are many regulators and checkpoints to ensure the proper cell cycle progression. Disruption of the machinery involved in completion, error...
Traditionally, mast cells have been studied for their role as proinflammatory effector cells in allergic disorders. Recent findings however have opened up the discussion in the community of immunologists regarding MCs should be considered as...
T cells. Melanoma -- Immunotherapy. Immunologic memory. Immune response -- Regulation. Medical Term T-Lymphocytes, Regulatory -- immunology. CD8-Positive T-Lymphocytes -- immunology. Melanoma, Experimental -- immunology.
The potential for the immune system to control growing tumors was recognized over a century ago. Studies during the past 20 years have presented undisputable evidence that host T cells have the ability to recognize, and kill tumor cells. However,...
In image-guided neurosurgery, preoperative magnetic resonance images (pMR) are typically used intraoperatively for neuronavigation. The accuracy of image guidance using preoperative images can be significantly compromised by intraoperative brain...
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Radio relics are extended regions of synchrotron radio emission that have been found in the outskirts of a few dozen galaxy clusters. Relics are often associated with clusters undergoing merger activity. They are not associated optically with a...