Dartmouth Digital Library Program

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Spectroscopy-based quantification of chromophores and scattering in near infrared tomography.
Near infrared reflectance spectroscopy. Breast -- Cancer -- Tomography. Breast -- Cancer -- Imaging. Breast -- Cancer -- Diagnosis. Image reconstruction. Diagnostic imaging. Image Processing
Dartmouth Dissertations

Forest structure and atmospheric interactions : predictive models for subalpine balsam fir forest
Forest hydrology -- Mathematical models; Forest Meteorology -- Mathematical models; Balsam fir
Dartmouth Dissertations

Enhancing non-determinism in operating systems / by Morgon Kanter.
Computer security has come a long way since the days of the first Internet worm. With the spreading and commercialization of the Internet, the stakes have gotten higher. Viruses existed and spread before most computers were online, but as global...
Dartmouth Dissertations

The mechanism of action for angiotensin-1-7 in the rostral ventrolateral medulla in the modulation of cardiovascular sympathetic nerve activity / by Mark S. Bilodeau
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Dartmouth Dissertations

Mesh-Mon: a monitoring and management system for wireless mesh networks.
Wireless communication systems. Computer networks. Routers (Computer networks).
A mesh network is a network of wireless routers that employ multi-hop routing and can be used to provide network access for mobile clients. Mobile mesh networks can be deployed rapidly to provide an alternate communication infrastructure for...
Dartmouth Dissertations

Structural characterization of the LysR-type virulence factor, AphB, and insight into its mehcanism of transcriptional activation at the tcpPH promoter in Vibrio cholerae
The LysR-type virulence regulator, AphB, initiates the Vibrio cholerae virulence cascade resulting in expression of the two critical virulence factors, toxin-coregulated pilus and cholera toxin, by activating transcription at the tcpPH promoter....
Dartmouth Dissertations

Effects of violent game play on attitudes toward behavioral deviance : mechanisms of self involvement, affective responses, and motivated attitude change / by Anna T. Prescott
Violent video games are immensely popular among children and adults, making it crucial to understand how these games affect the thoughts, feelings, and behaviors of those who play them. The present research proposed an account by which video game...
Dartmouth Dissertations

The role of glia in neuropathic pain: a journey into the tetrapartite synapse.
Neuroglia -- Effect of drugs on. Astrocytes. Opioids -- Physiological effect. Central nervous system -- Pathophysiology. Nerves
Neuropathic pain is a debilitating condition that affects millions of individuals worldwide. Unfortunately, opioids are only partially effective in treating neuropathic pain while entraining tolerance and a myriad of side effects from the high...
Dartmouth Dissertations

Design and end-to-end test of a cloud-based Mobile Product Authentication architecture for low resource environments
Product counterfeiting -- Prevention.;""Drugs -- Marketing -- Corrupt practices -- Nigeria -- Prevention."";""Computer architecture."";""Cloud computing -- Security measures."";""Mobile computing -- Security measures.""
Dartmouth Dissertations

The role of K⁺ channels and redox potential in the strain-dependent response to hypoxia.
Anoxemia -- Molecular aspects. Potassium channels. Oxidation-reduction reaction. Cell Hypoxia -- physiology.
Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF 1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO 2 , increased [Hb], and increased mortality....
Dartmouth Dissertations

Harmonics based detection of magnetic nanoparticle dynamics for multiparameter biosensing
Nanoparticles -- Magnetic properties.;""Harmonics (Electric waves)"";""Biosensors."";""Spectrum analysis."";""Brownian motion processes.""
Magnetic nanoparticles have an increasing role in the clinical and pharmaceutical realms where their physical properties can be exploited for imaging, biological and functional sensing, control of cellular processes, therapeutics, and an array of...
Dartmouth Dissertations

Non-resonant photon absorption by reactive chemical systems.
Lasers in chemistry. ; Zinc. ; Oxidation-reduction reaction.
Dartmouth Dissertations

Perturbation of Eg5 reveals insights into mitotic spindle structure and mechanics.
Spindle (Cell division) Microtubules. Kinesin. Medical Term Molecular Motor Proteins. Microtubule-Associated Proteins.
A pre-requisite for proper health of the cell and the organism is accurate chromosome segregation during cell division. Defects in chromosome segregation lead to aneuploidy, a hallmark of an unstable genome and a frequent attribute of cancer and...
Dartmouth Dissertations

Dependence of snow thermal and electrical conductiveness on microstructure.
Snow -- Thermal properties. ; Snow -- Electric properties. ; Microstructure.
Dartmouth Dissertations

Numerical methods in electromagnetics : evanescent nanometry for DNA sequencing, and EM induction for UXO detection and discrimination / by Alex Bijamov.
Mice -- Morphogenesis.;""Mice -- Genetics."";""Transcription factors."";""Cellular signal transduction."";""Genetic regulation."";""GATA4 Transcription Factor -- genetics."";""Wnt Proteins -- physiology.""
Dartmouth Dissertations

Electrical impedance acquisition system for surgical margin assessment during robot-assisted laparoscopic prostatectomy / by Shadab Khan
Prostate cancer (PCa) recurrences are often predicted by assessing the status of surgical margins (SM) – positive surgical margins (PSM) increase the chances of biochemical recurrence by 2-4 times which may lead to PCa recurrence. At present,...
Dartmouth Dissertations

Motion optimized conformal microwave imaging for biomedical applications / by Neil R. Epstein.
Investigations into alternative breast cancer (BC) imaging techniques have become increasingly popular based on the limitations of traditional imaging modalities: X-ray mammography uses ionizing radiation, has limited intrinsic contrast and is...
Dartmouth Dissertations

5-azacytidine induces fetal hemoglobin by a cell signalling mechanism that is upstream of changes in differentiation kinetics and promoter hypomethylation.
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Dartmouth Dissertations

Thermodynamic and spectroscopic studies of metalloprotein stability ligation and reactivity / by George P. Lisi III.
Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
Dartmouth Dissertations

On facial mimicry and facial feedback.
Imitation. ; Facial expression. ; Smiling. ; Laughter.
Dartmouth Dissertations

Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.
Drosophila melanogaster -- Genetic aspects. Prion diseases. Neurotransmitters. Photoreceptors.
Drosophila melanogaster is a model organism often used when studying the complex processes of neuronal signaling and neurodegeneration. The short life cycle, malleable genetics, amenability to in vivo electrophysiological assays and sensitivity to...
Dartmouth Dissertations

Re-programming tumor-infiltrating dendritic cells in situ via RNAi elicits therapeutic immunity against ovarian cancer.
Ovaries -- Cancer -- Immunotherapy. Dendritic cells. Small interfering RNA. Nanoparticles -- Therapeutic use. Medical Term Ovarian Neoplasms -- therapy. RNA Interference.
Current therapies for ovarian carcinoma are based on surgical debulking followed by chemotherapy. After more than three decades implementing treatments that selectively target the tumor cell, the 5-year survival rate for metastatic ovarian cancer...
Dartmouth Dissertations

Role of melanin concentrating hormone (MCH) containing neurons in the lateral hypothalamus in cardiorespiratory control and energy balance / by Ningjing Li.
The lateral hypothalamus is a brain region involved in the regulation of feeding, glucose homeostasis, sleep/wake cycle, and autonomic nervous system (ANS). Melanin concentrating hormone (MCH) containing neurons, located in the lateral...
Dartmouth Dissertations

MRI-coupled broadband near-infrared tomography for small animal brain studies.
Brain -- Tomography. Magnetic resonance imaging -- Brain. Near infrared spectroscopy. Image processing -- Digital techniques.
Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and...
Dartmouth Dissertations

Mapping ultramafic rocks by computer analysis of digital LANDSAT data.
Rocks Ultrabasic. ; Geology -- Data processing.
Dartmouth Dissertations

Genetic regulation of PBP2 and PBP4 in community-acquired methicillin-resistant Staphylococcus aureus
Staphylococcus aureus contains 4 native, membrane-bound penicillin-binding proteins (PBP1-4) which are responsible for critical peptidoglycan transglycosylation and transpeptidation reactions in the cell wall. Additionally, PBP2 and PBP4 also...
Dartmouth Dissertations

Synthesis and characterization of phosphido-coated gold nanoclusters and gold phosphido complexes.
Gold -- Analysis. Gold compounds. Metal complexes -- Synthesis. Phosphides. Ligands.
Chapter one: Gold(I) phosphido complexes: Synthesis, structure and reactivity . Deprotonation of the phosphine complexes Au(PHR 2 )Cl with aqueous ammonia gave the gold(I) phosphido complexes [Au(PR 2 )] n (PR 2 = PMes 2 ( 1 ), PCy 2 ( 2 ), P(t-Bu)...
Dartmouth Dissertations

The use of computer models to capture, understand and control dynamic brain processes.
Brain -- Physiology -- Mathematical models. Brain stem -- Effect of chemicals on. Basal ganglia -- Physiology.
Understanding how the brain works remains one of the toughest problems in science, despite the progress in scientific technology available for its study. The difficulty lies in the fact that the brain is a dynamic system, while the body of facts...
Dartmouth Dissertations

Pharmacologic induction of human fetal hemoglobin through activation of the NRF2 antioxidant response signaling pathway
Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
Dartmouth Dissertations

Effects of particles on anelasticity, creep and microstructural evolution of granular ice.
Ice mechanics. Internal friction. Ice -- Creep. Particles. Dislocations in crystals.
This work studied the effects of silt-sized particles on the mechanical properties and microstructures of laboratory-grown granular ice from -20¬∞C to -2¬∞C. Experimental findings show that such particles significantly affect the...
Dartmouth Dissertations

Investigation of ER-Golgi membrane proteins influencing COPII tethering and fusion / by Indrani Mukherjee
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Dartmouth Dissertations

Applications of Cherenkov light emission for dosimetry in radiation therapy / by Adam Kenneth Glaser
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
Dartmouth Dissertations

Hierarchical reinforcement learning and social cognition in cooperative multi-robot foraging
Robots.;""Reinforcement learning."";""Social interaction."";""Cooperation."";""Biomimetics.""
Dartmouth Dissertations

Electrical impedance imaging for temperature field estimation during hyperthermia treatment of cancer.
Electrical impedance tomography. Newton-Raphson method. Cancer -- Thermotherapy -- Technique.
Dartmouth Dissertations

The identification of molecular targets of synthetic oleanane triterpenoids
Terpenes -- Mechanism of action. ; Protein kinases -- Inhibitors. ; Oleanolic Acid.
Synthetic oleanane triterpenoids (SO) are a novel class of therapeutic compounds based on the structure of oleanolic acid. These synthetic oleanane triterpenoids which include 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), CDDO-methyl...
Dartmouth Dissertations

Thermodynamic Studies of Metal Interactions with Four Biomolecules Using Isothermal Titration Calorimetry / by Margaret C. Carpenter
Some biomacromolecules require a metal co-factor to stabilize their physiologically active three-dimensional structure. The fundamental thermodynamic values of the binding of metal ions, particularly Zn2+, to a set of biomacromolecules have been...
Dartmouth Dissertations

A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
Dartmouth Dissertations

The site-specific modification of therapeutic proteins produced in Escherichia coli : implementation of a combinatorial bispecific antibody fragment library against human breast carcinomas
Immunoglobulins -- Synthesis. -- Escherichia coli -- Biotechnology -- Protein engineering -- Breast -- Cancer -- Immunotherapy.
The ability to site-specifically modify therapeutic proteins for the attachment of pharmacokinetic-enhancing molecules is the principal goal of many research programs. Site-specific modalities are often introduced to provide an additional...
Dartmouth Dissertations

Regulation of human monocyte CD163 during the innate immune response to infection.
CD antigens. Immune response -- Regulation. Hemoglobin.
CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
Dartmouth Dissertations

Discovery and characterization of the calmodulin-binding Pcdp1 complex required for coordination of dynein-driven flagellar motility
Calmodulin.;""Dynein."";""Cells -- Motility."";""Co-Repressor Proteins/""
Dartmouth Dissertations

Metabolic engineering of high yield ethanol production in Thermoanaerobacterium saccharolyticum.
Microbial metabolism. ; Microbial genetic engineering. ; Thermophilic bacteria -- Genetic engineering. ; Anaerobic bacteria -- Genetic engineering.
A sustainable energy future is critical for environmental and strategic reasons. One alternative to petroleum used for transportation is ethanol derived from cellulosic biomass. The major barrier for biomass conversion is a cost effective method...
Dartmouth Dissertations

Damage identification in smart structures through sensitivity enhancing control.
Structural control (Engineering). ; Smart structures -- Vibration. ; Strains and stresses -- Computer simulation. ; Automatic control -- Sensitivity. ; Feedback control systems.
This thesis investigates vibration-based damage identification problems in smart structures. Vibration-based damage metrics suffer from small sensitivity of modal properties to damage, thus making it difficult to detect, locate, and determine the...
Dartmouth Dissertations

Expression and recovery of recombinant proteins in a novel high cell density prokaryotic system based on Ralstonia eutropha.
Ralstonia -- Biotechnology. Microbial biotechnology. Industrial microbiology. Recombinant proteins -- Synthesis. Recombinant Proteins -- Biosynthesis.
Escherichia coli is the standard host for recombinant protein expression in bacteria, but suffers from some limitations (e.g. poor fermentation performance, inclusion body formation and proteolysis). A novel recombinant protein expression system,...
Dartmouth Dissertations

Attributing change and understanding melt ponds on a seasonal ice cover.
Sea ice -- Arctic Ocean -- Measurement. ; Melt ponds -- Arctic Ocean -- Measurement. ; Sea ice -- Permeability.
Dartmouth Dissertations

Determinants of the il-1β response to Pseudomonas aeruginosa / by Yash R. Patankar
IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

Light and circadian regulation in Neurospora crassa.
Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
Dartmouth Dissertations

Control of emotion.
Emotions. ; Self-control. ; Facial expression .
Dartmouth Dissertations

DNA damage-induced cell cycle checkpoints as a target for cancer therapy.
Cancer cells -- Proliferation -- Molecular aspects. Biological control systems. Cancer cells -- Growth -- Regulation. Breast -- Cancer -- Genetic aspects. p53 protein. Cell cycle. DNA damage. Cellular signal transduction. Carcinogenesis --...
Cells respond to DNA damage by activating signal transduction pathways that cause cell cycle arrest at checkpoints in G 1 , S, or G 2 phases of the cell cycle; this allows time for repair of damaged DNA. The G 1 checkpoint is dependent upon the...
Dartmouth Dissertations

Structural studies of Vibrio cholerae virulence gene regulators.
Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
Dartmouth Dissertations

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