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All fields: SYNERGY

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- Immunotherapy of B-cell malignancies: directing T-cell responses and blocking lineage-specific survival factor pathways.
- B cells -- Tumors. ; Cancer -- Immunotherapy. ; T cells. ; CD antigens.
- The indolent B-cell malignancies of lymphoma and myeloma account for a great number of adult cancers in the United States annually. Hi-dose combination chemotherapy, bone marrow transplants and monoclonal antibody therapeutics have improved the...
- Dartmouth Dissertations
- Enzymatic hydrolysis of cellulosic biomass solids prepared by leading pretreatments and identification of key features governing performance.
- Cellulase -- Absorption and adsorption. Enzymes -- Biotechnology. Cellulose -- Biodegradation. Lignocellulose -- Biotechnology. Biomass conversion. Hydrolysis. Corn stover. Poplar -- Biotechnology.
- Prior to biological conversion of lignocellulosic biomass, natural barriers to efficient enzymatic hydrolysis must be overcome, and a few pretreatment technologies effectively accomplish this job with chemicals. Although several factors are...
- Dartmouth Dissertations
- Thayer School: April 1999; Thayer School; National...
- Dartmouth College Photographic Records
- Amarendra K. Das, Associate Professor of Psychiatr...
- Dartmouth College Photographic Records
- Amarendra K. Das, Associate Professor of Psychiatr...
- Dartmouth College Photographic Records
- Amarendra K. Das, Associate Professor of Psychiatr...
- Dartmouth College Photographic Records
- Amarendra K. Das, Associate Professor of Psychiatr...
- Dartmouth College Photographic Records
- Amarendra K. Das, Associate Professor of Psychiatr...
- Dartmouth College Photographic Records
- Apoptosis as a mechanism of cell death by anticancer agents.
- Apoptosis. Antineoplastic agents.
- Dartmouth Dissertations
- Characterization of the molecular mechanism by which arsenic and chromium alter inducible gene expression.
- Arsenic -- Mechanism of action. ; Arsenic -- Toxicology. ; Chromium -- Mechanism of action. ; Chromium -- Toxicology. ; Gene expression.
- Metals are ubiquitous in our environment. Through evolution, many biological processes have taken advantage of and have become dependent on specific metals for various biochemical functions. Metals can also be toxic to biological systems at...
- Dartmouth Dissertations
- Cellulosic biomass to ethanol: kinetic modeling, scale up, and reactor design.
- Bioreactors -- Design and construction. ; Biochemical engineering -- Computer simulation. ; Mixing. ; Fermentation. ; Alcohol as fuel. ; Biomass energy.
- Biological conversion of biomass to fuels and chemicals offers recognized benefits. The absence of systematic methodologies for scaling up such conversion is an important issue related to realizing these benefits. This thesis addresses this scale...
- Dartmouth Dissertations
- Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
- A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
- Dartmouth Dissertations
- Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
- Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
- Dartmouth Dissertations
- Simultaneous saccharification and co-fermentation of paper sludge.
- Cellulose -- Biodegradation. Zymomonas mobilis -- Biotechnology. Saccharomyces cerevisiae -- Biotechnology. Fermentation. Hydrolysis. Biomass conversion -- Mathematical models.
- Production of fuel ethanol from cellulosic materials is a potentially attractive way to meet sustainability, energy security, and environmental goals. However, the high cost of processing using current technology has thus far prevented...
- Dartmouth Dissertations
- Chemico-physical and pharmacologic factors that influence delivery of IONPs to tumors in rodent breast cancer models / by Jennifer Tate.
- Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
- Dartmouth Dissertations
- Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
- Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
- Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
- Dartmouth Dissertations
- Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
- Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
- Dartmouth Dissertations
- The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
- Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
- We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
- Dartmouth Dissertations
- Combined digital breast tomosynthesis and near-infrared spectral tomography for breast lesion characterization / by Kelly E. Michaelsen.
- Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
- Dartmouth Dissertations
- Multimodal electroencephalography and near-infrared spectroscopy neuroimaging measurement and analysis / by Paolo Giacometti
- This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
- Dartmouth Dissertations
- Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
- Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
- Dartmouth Dissertations
- Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
- Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
- Dartmouth Dissertations
- Secure collaboration in an open environment.
- Internet -- Security measures. Public key infrastructure (Computer security). Digital signatures. Peer-to-peer architecture (Computer networks) -- Security measures.
- The Internet has become a virtual place where people not only operate in isolation but also interact with other Internet users. Collaborative systems are becoming more popular. Applications now being introduced could provide better remote education...
- Dartmouth Dissertations
- Integration of machine learning network science and pathway analysis in genetic epidemiology / by Qinxin Pan.
- Although genome-wide association studies (GWAS) and other high-throughput initiatives have led to an information explosion in human genetics and genetic epidemiology, the mapping from genotype to phenotype remains challenging as most of the...
- Dartmouth Dissertations
- The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
- Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
- Dartmouth Dissertations
- The role of mediator in white-opaque switching / by Anda Zhang.
- The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
- Dartmouth Dissertations
- Metabolic engineering of catabolic product metabolism in thermophilic bacteria.
- Thermophilic bacteria -- Metabolism. Thermophilic bacteria -- Genetics. Thermophilic bacteria -- Biotechnology. Cells
- Metabolic engineering of the catabolic end-product metabolism of Thermoanaerobacterium saccharolyticum was initiated. T. saccharolyticum is an anaerobic, thermophilic bacterium that utilizes xylans and xylose, the second most prominent sugar after...
- Dartmouth Dissertations
- Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
- T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
- Dartmouth Dissertations
- Regulation of B lymphocyte proliferation and differentiation through CD40.
- B cells. CD antigens. Immune response -- Regulation.
- Dartmouth Dissertations
- Dendritic cell Fcγ receptor expression and function
- Fc receptors. Dendritic cells. Immune recognition.
- Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
- Dartmouth Dissertations
- Hepatic toxicity and compensatory hyperplasia in a rat model of aflatoxin bi-induced liver cancer
- Liver -- Cancer -- Etiology. Hepatotoxicology. Aflatoxins -- Toxicology. Taurine. Liver -- Cancer -- Animal models.
- A hypothesis that chronic aflatoxin Bi- (AFBi) induced hepatotoxicity and the resulting compensatory cell proliferation are critical for the growth of preneoplastic lesions was investigated. A commonly utilized protocol which consists of 10 doses...
- Dartmouth Dissertations
- UCN-01: a protein kinase antagonist abrogating cell cycle checkpoint control.
- Protein kinase C -- Antagonists. Cells -- Growth -- Regulation. Antineoplastic agents -- Mechanism of action.
- Dartmouth Dissertations
- Neural and behavioral correlates of auditory-object processing.
- Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
- The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
- Dartmouth Dissertations
- Quantitative risk analysis of computer networks.
- Computer networks -- Security measures. Computer security. Risk assessment. Operating systems (Computers) -- Evaluation.
- Quantitative Risk Analysis of Computer Networks (QSRA) addresses the problem of risk opacity of software in networks. It allows risk managers to get a detailed and comprehensive snapshot of the constitutive software on the network, assess its risk...
- Dartmouth Dissertations
- The adaptation of a potential function controller for control of a dynamic multi-robot system.
- Robots -- Control systems -- Design and construction. Mobile robots. Robots -- Dynamics.
- This thesis examines the issues of vehicle and information dynamics in the control of a multi-robot system using a radial-basis potential function controller. Distributed control of multi-robot systems requires each robot to communicate state...
- Dartmouth Dissertations
- Computational methods for microwave medical imaging.
- Microwave imaging -- Mathematics. ; Three-dimensional imaging -- Mathematics. ; Image reconstruction -- Mathematics. ; Microwave imaging in medicine. ; Computer algorithms.
- Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
- Dartmouth Dissertations
- SHEMP: secure hardware enhanced MyProxy.
- Public key infrastructure (Computer security). ; Computer networks -- Security measures. ; Operating systems (Computers). ; Microcomputers.
- In 1976, Whitfield Diffie and Martin Hellman demonstrated how public key cryptography could enable secure information exchange between parties that do not share secrets. In order for public key cryptography to work in modern distributed...
- Dartmouth Dissertations
- The differentiation and survival of long-lived plasma cells.
- Plasma cells. ; Lymphocyte transformation. ; B cells. Immune response -- Regulation. ; Immunologic Memory -- physiology.
- During an immune reaction to an invading pathogen, a population of lymphocytes with receptors that specifically recognize the pathogen are activated and become memory cells. Characteristically, memory lymphocytes persist for long periods of time...
- Dartmouth Dissertations
- Glucocorticoids and interferons regulate the expression of a novel human mononuclear phagoctye-specific antigen.
- Antigens. ; Immune response -- Regulation. ; Glucocorticoids -- Physiological effect.
- Dartmouth Dissertations
- Primate origins through the lens of functional and degenerate cone opsins / by Gillian L. Moritz
- A nocturnal activity pattern is central to almost all hypotheses on the adaptive origins of primates but this view has been challenged recently on the basis of variation in the cone opsin genes of nocturnal primates. The diversity among primates in...
- Dartmouth Dissertations
- Detecting, characterizing and interpreting Gene-Gene interactions associated with metabolic traits / Rishika De
- The ubiquitous complexity of common diseases is one of the biggest challenges facing the field of personalized treatments and precision medicine. This complexity can be attributed to various sources such as the genetic make-up of an individual,...
- Dartmouth Dissertations
- Design of a magnetic field compatible, high-performance optical breast imaging system for MRI-guided optical spectroscopy / by Fadi El-Ghussein
- Multimodality imaging is becoming the standard of care for research and clinical studies. Such an approach is able to provide complementary information which can detect and characterize tumors. Advancing instrumentation for diffuse near-infrared...
- Dartmouth Dissertations
- Interrogation of autolysins as a source of novel bacteriolytic agents / by Daniel Carmen Osipovitch
- Staphylococcus aureus is a formidable pathogen, and its high morbidity and mortality rates are compounded by its ability to quickly develop antibiotic resistance. The current antimicrobial pipeline is inadequate to curb this mounting public health...
- Dartmouth Dissertations
- Studies of adaptive immune responses: factors mediating the biology of adaptive T regulatory cells, plasma cells, and memory B cells.
- Immune response -- Regulation. Tretinoin. T cells. B cells. Plasma cells. Immunity.
- Adaptive immunity licenses higher organisms to generate potent immune responses against foreign antigens. Two hallmarks of adaptive immunity are A) the ability of T and B cells to distinguish self from non-self and B) the ability to mount a...
- Dartmouth Dissertations
- Uniform avoidance coupling, design of anonymity systems and matching theory / by Ewa Joanna Infeld
- We start by introducing avoidance coupling of Markov chains, with an overview of existing results. We then introduce and motivate a new notion, uniform coupling. We show that the only Markovian avoidance coupling on a cycle is of this type, and...
- Dartmouth Dissertations
- Isolation of interleukin-2-induced immediate-early genes.
- Interleukin-2.
- Dartmouth Dissertations
- Th-dependent B cell activation.
- B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
- Dartmouth Dissertations
- Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
- Dendritic cells. Biological response modifiers. Immune response -- Regulation. T cells. CD antigens. Dendritic Cells -- Immunology. Receptors
- Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature...
- Dartmouth Dissertations
- The identification and characterization of aldosterone responsive genes.
- Aldosterone. ; Genetic regulation. ; Mineralocorticoids -- Receptors.
- Dartmouth Dissertations
- In vitro reconstitution of exocytosis from sea urchin egg plasma membrane and isolated secretory vesicles.
- Sea urchins -- Cytology.
- Dartmouth Dissertations

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