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The Spot 14 gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism.
Nucleoproteins. ; Fatty acids -- Synthesis -- Genetic aspects. ; Breast -- Cancer -- Genetic aspects. ; Gene amplification. ; Oncogenes.
Spot 14 (S14) is a ~17 KD nuclear protein that functions at the transcriptional level to regulate de novo synthesis of fatty acids in liver, brown and white adipose, and. lactating mammary tissues. Localization of the S14 gene to chromosome 11q13.5...
Dartmouth Dissertations

Commencement Honorary Degrees 1940's
Commencement
Commencement - honorary degrees 1942; Cyrus Stuart Ching; John Eliot Allen, '94; Chinese Ambassador Hu Shih; President Hopkins; Frank Berry Sanborn '87; John Livingstone Laury (?); Dartmouth Alumni Magazine, June 1942, page 20
Dartmouth College Photographic Files

The Martin Luther King, Jr. Celebration Social Jus...
2005-01-29_justice
Dartmouth College Photographic Records

Structure/function analyses of the murine -globin locus through trageted mutations.
Globin genes -- Expression. Genetic markers. Genetic transcription -- Regulation. Mutation (Biology).
Genes at the mammalian β-globin loci are arranged in the order of their developmental activation. Expression of individual genes at this locus is controlled by gene proximal and distal cis -regulatory elements. This thesis focused on the function...
Dartmouth Dissertations

Operation of a Smith-Purcell free-electron laser at submillimeter wavelengths.
Free electron lasers. ; Millimeter wave devices.
Dartmouth Dissertations

Geometrical and probabilistic methods for determining association models and structures of protein complexes / by Himanshu Chandola.
Protein complexes play vital roles in cellular processes within living organisms. They are formed by interactions between either different proteins (hetero-oligomers) or identical proteins (homo-oligomers). In order to understand the functions of...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Phosphoproteomic strategies to identify aberrant kinase signaling in lung cancer / by Devin Karl Schweppe
Lung cancer is the leading cause of cancer-related death in the USA and worldwide causing 160,000 and 1.5 million deaths per year, respectively. Due to the late stage of diagnosis, poor efficacy of chemotherapies (targeted and pleiotropic), and...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Noninvasive fluorescence monitoring for functional assessment of murine glioma treatment.
Gliomas -- Immunotherapy -- Evaluation. Fluorescence spectroscopy. Diagnosis.
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

Smith-Purcell radiation from relativisitc electrons: theory and experiment.
Electrons -- Diffraction. Diffraction gratings -- Experiments. Quantum electrodynamics.
Dartmouth Dissertations

A far-infrared Smith-Purcell micro-radiator.
Infrared radiation. Infrared sources. Infrared technology.
Dartmouth Dissertations

Implementation, characterization, and applications of a scanning Kelvin probe force microscope.
Scanning force microscopy. Scanning electron microscopes -- Design and construction. Semiconductors -- Analysis.
Dartmouth Dissertations

Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
Dartmouth Dissertations

Synthetic studies of ellipticine alkaloids and structurally related compounds.
Alkaloids -- Synthesis.
Dartmouth Dissertations

The effects of endocrine disruptors on the development of Xenopus embryos.
Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
Dartmouth Dissertations

The planar orotron: a metal grating coupled, millimeter wavelength radiation source.
Millimeter wave devices.
Dartmouth Dissertations

Novel syntheses of polycyclic aromatic hydrocarbons.
Aromatic compounds. ; Polycyclic compounds. ; Diels-Alder reaction.
Dartmouth Dissertations

A self-consistent analysis of far-infrared and sub-millimeter wavelength metal-grating free electron lasers.
Free electron lasers.
Dartmouth Dissertations

Applications of Cherenkov light emission for dosimetry in radiation therapy / by Adam Kenneth Glaser
Since its discovery in the 1930's, the Cherenkov effect has been paramount in the development of high-energy physics research. It results in light emission from charged particles traveling faster than the local speed of light in a dielectric...
Dartmouth Dissertations

Kinetochore influence on mitotic spindle structure.
Spindle (Cell division). Microtubules. Mitosis. Kinetochores -- physiology. Microtubule-Associated Proteins -- physiology.
Proper chromosome alignment and segregation depends on the formation and maintenance of a bipolar mitotic spindle with focused poles. It has been shown that microtubules are focused at spindle poles through the combined actions of centrosomes and a...
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

Anchor-free localization in mixed wireless sensor network systems.
Sensor networks. Wireless LANs. Algorithms.
Recent technological advances have fostered the emergence of Wireless Sensor Networks (WSNs), which consist of tiny, wireless, battery-powered nodes that are expected to revolutionize the ways in which we understand and construct complex physical...
Dartmouth Dissertations

Studies of adaptive immune responses: factors mediating the biology of adaptive T regulatory cells, plasma cells, and memory B cells.
Immune response -- Regulation. Tretinoin. T cells. B cells. Plasma cells. Immunity.
Adaptive immunity licenses higher organisms to generate potent immune responses against foreign antigens. Two hallmarks of adaptive immunity are A) the ability of T and B cells to distinguish self from non-self and B) the ability to mount a...
Dartmouth Dissertations

The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
Partially ordered sets. ; Forcing (Model theory). ; Set theory.
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

Bcl-2 family proteins and the regulation of apoptosis.
Apoptosis. ; Proteins. ; Cellular signal transduction. ; Proto-Oncogene Proteins c-bcl-2.
Apoptosis is induced by chemicals and death receptor activation. Although the stimuli are different, common proteins are activated downstream. The Bcl-2 family of proteins plays an important role in mediating apoptotic signaling at the mitochondria...
Dartmouth Dissertations

Actions of substances placed in the cat cerebrospinal fluid space.
Pharmacology, Experimental. ; Cats.
Dartmouth Dissertations

The regulation of apoptosis by protein phosphatases: impact on intracellular acidification and processing of the retinoblastoma protein.
Apoptosis. ; Phosphoprotein phosphatases. ; Retinoblastoma. ; Immunosuppression.
Dartmouth Dissertations

Investigation of trans-acting factors in AURE-mediated mRNA turnover.
Messenger RNA -- Metabolism. ; Trans-Activation (Genetics). ; RNA-protein interactions. ; Adenosine. ; Uridine. ; Lactate dehydrogenase. ; Genetic regulation. ; RNA-Binding Proteins. ; Protein processings Post-transcriptional. ; Hippel-Lindau...
Post-transcriptional pathways provide a major means of regulating eukaryotic gene expression. Reiterations of the AU-rich element (AURE) located within the 3' UTR of many labile cytokine and proto-oncogene mRNA serve as signals for rapid...
Dartmouth Dissertations

Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
Dartmouth Dissertations

The effect of movie smoking on smoking attitudes and behavior.
Smoking in motion pictures. ; Mass media and teenagers -- United States. ; Mass media and young adults -- United States. ; Teenagers -- United States -- Attitudes. ; Young adults -- United States -- Attitudes. ; Motion picture actors and actresses...
Thousands of adolescents try their first cigarette each day, and many of these adolescents go on to become adult smokers who will die from smoking-related causes. This thesis examines the role of movie portrayals of smoking as a predictor of...
Dartmouth Dissertations

Mutational studies of simian virus 40 large T antigen.
Tumor antigens. ; SV40 (Virus).
Dartmouth Dissertations

Early earth and solar system evolution: insights from strontium, barium, neodymium, and samarium isotopes.
Chondrites (Meteorites). ; Mantle plumes. ; Samarium-neodymium dating. ; Strontium -- Isotopes. ; Barium -- Isotopes. ; Solar system. ; Earth -- Mantle.
Dartmouth Dissertations

Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Dartmouth Dissertations

Large-scale structure of the universe: a clustering analysis.
Cosmology -- Mathematical models. ; Galaxies -- Clusters -- Mathematical models. ; Dark matter (Astronomy).
Dartmouth Dissertations

The formation of chloroform and related products from the chlorination of polyhydroxybenzenes and diketones in dilute aqueous solution.
Chloroform. ; Chlorination.
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent regularion of cholesterol biosynthesis and LDL receptor expression.
Molecular cloning. ; Genetic regulation. ; Somatic cells. ; Sterols. ; Cholesterol -- Metabolism.
Dartmouth Dissertations

Respiratory-related hypoglossal activities in decerebrate cats.
Hypoglossal nerve. ; Airway (Medicine). ; Respiration.
Dartmouth Dissertations

Assisting human motion-tasks with minimal, real-time feedback.
Human locomotion -- Computer-assisted instruction. ; Real-time data processing. ; Human-computer interaction.
Teaching physical motions such as riding, exercising, swimming, etc. to human beings is hard. Coaches face difficulties in communicating their feedback verbally and cannot correct the student mid-action; teaching videos are two dimensional and...
Dartmouth Dissertations

TGF-beta1 regulation of Th1 development and autoimmunity.
Transforming growth factors-beta. ; Th1 cells. ; Transcription factors. ; Autoimmunity. ; Cytokines. ; Immune response -- Regulation. ; T cells. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Synthetic studies on viridin class of furanosteroids.
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
Dartmouth Dissertations

Synthetic studies toward the furanosteroids.
Furans -- Synthesis. Steroid drugs. Enzyme inhibitors -- Therapeutic use. Cancer cells -- Growth -- Regulation.
The furanosteroids are an important class of natural products that have been found to effectively inhibit various biologically important enzymes. These enzymes include the phosphoinositide-3-kinase (PI3K) family and the polo-like kinase (PLK1)...
Dartmouth Dissertations