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    • Modulation of CYPS: effect on acetaminophen hepatotoxicity.

    • Modulation of CYPS: effect on acetaminophen hepatotoxicity.
    • Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Acetaminophen -- Toxicology. ; Alcohol -- Pathophysiology.
    • Cytochrome P450 (CYP) 2E1 is considered the sole CYP responsible for APAP bioactivation leading to hepatotoxicity. CYP2E1 is also considered the alcohol-inducible CYP and therefore, the sole CYP responsible for alcohol-mediated increases in APAP...
    • Constructing a dynamic model of hedgehog signaling.

    • Constructing a dynamic model of hedgehog signaling.
    • Cellular signal transduction. Transcription factors. cos protein, Drosophila. Medical Terms: Hedgehog Proteins; Signal Transduction -- physiology; ci protein, Drosophila.
    • The evolutionarily conserved Hedgehog (Hh) signaling pathway is required for proper embryonic patterning and development. Deregulated Hh signaling has been implicated in various human carcinomas and developmental defects, thus elucidation of the...

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