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Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Runx1 is required in vascular endothelial cadherin expressing cells for hematopoietic stem cell emergence.
Transcription factors. Hematopoietic stem cells -- Genetic aspects. Hematopoiesis -- Regulation. DNA-binding proteins. Vascular endothelium.
Hematopoietic stem cells (HSCs) are the cells that can give rise to all different lineages of differentiated/mature blood cells. HSCs are capable of self-renewal and maintaining the homeostasis of differentiated cells for specific functions. The...
Dartmouth Dissertations

Dendritic cell Fcγ receptor expression and function
Fc receptors. Dendritic cells. Immune recognition.
Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
Dartmouth Dissertations

Isolation and functional characterization of yeast vacuole snare complexes.
Membrane proteins -- Physiological transport. ; Plant proteins -- Physiological transport. ; Biological transport -- Regulation. ; Plant vacuoles. Saccharomyces cerevisiae -- Physiology.
Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Genetic screens and reconstituted biochemical assays have revealed that intracellular protein trafficking is mediated by a conserved mechanism of vesicle budding, transport,...
Dartmouth Dissertations

The importance of dosage of core binding factors α and ß in hematopoietic development.
Hematopoiesis -- Regulation. ; Transcription factors.
Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
Dartmouth Dissertations

microRNA in Porifera : evolution of a molecular mechanism in sponges / by Jeffrey Robinson
Sponges are a historically ambiguous taxon, often considered primitively simple representatives of early Metazoa, living fossils from the era before the complex morphological features of the bilaterian phyla appeared in the Cambrian. Yet recent...
Dartmouth Dissertations

Investigation of ER-Golgi membrane proteins influencing COPII tethering and fusion / by Indrani Mukherjee
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Dartmouth Dissertations

I. Reactivity of electron deficient indoles toward nucleophiles, Diels-Alder reactions and dipolar cycloadditions; II. Synthesis of pyrrolo[3,4-b]indoles.
Indole -- Synthesis. Indole -- Reactivity. Pyrroles. Diels-Alder reaction.
Earlier in our laboratory, a facile synthesis of the 2- and 3-nitroindoles was realized. These compounds showed promise as powerful intermediates in the synthesis of novel structures and natural products. The reactivity of 2- and 3-nitroindoles...
Dartmouth Dissertations

Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Dartmouth Dissertations

Inertial coupling in two-phase flow: a few test cases and their impacts on two-fluid modeling.
Two-phase flow. ; Couplings.
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

Biochemical characterization of recombinant acyl coenzyme A:cholesterol acyltransferase expressed in insect Sf9 cell.
Acyltransferases. ; Enzymatic analysis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation. ; Genetic recombination.
Dartmouth Dissertations

Design and synthesis of novel tricyclic-bis-enones: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
Alicyclic compounds -- Synthesis. ; Nitric-oxide synthase -- Inhibitors. ; Cyclooxygenases -- Inhibitors. ; Macrophages. ; Oxidoreductases -- Inhibitors. ; Inflammation -- Mediators -- Pathophysiology.
Dartmouth Dissertations

Synthesis of porphobilinogen and studies on the synthesis of cobyric acid.
Tetrapyrroles -- Synthesis. ; Porphyrins -- Synthesis. ; Vitamin B12 -- Synthesis.
This thesis describes the synthetic study of two biologically related natural products: porphobilinogen (PBG) and cobyric acid. PBG is the key intermediate in the biosynthesis of all naturally occurring tetrapyrrolic 'pigments of life', including...
Dartmouth Dissertations

Molecular mechanisms of vacuole membrane fusion.
Membrane fusion. ; Tonoplasts. ; Plant vacuoles. ; Saccharomyces cerevisiae -- Molecular aspects.
The docking and fusion of cellular membranes plays an essential role in the secretory and endocytic pathways and in organelle inheritance. The homotypic fusion of vacuoles from the yeast Saccharomyces cerevisiae has been used as a model system to...
Dartmouth Dissertations

Runx1 expression and function in the development of murine definitive hematopoietic stem cells and blood lineages.
Transcription factors. ; Hematopoietic stem cells -- Genetic aspects. ; DNA-binding proteins. ; Mutation (Biology).
Dartmouth Dissertations

Investigation into the syntheses and reactions of 2-nitroindoles and 3-nitroindoles and discovery of novel syntheses of the pyrrolo[3,4-b]indole and pyrrolo[2,3-b]indole ring systems.
Carbazole -- Synthesis. ; Indole. ; Pyrroles.
A new synthetic approach to both pyrrolo[2,3- b]indoles and pyrrolo[3,4- b]indoles by the reaction of 3-nitro-1-(substituted)indoles with functionalized isocyanides is presented. The reaction between 3-nitro-1-(phenylsulfonyl)indole (185) and ethyl...
Dartmouth Dissertations

Versatile 2-lithioindoles, syntheses and Diels-Alder reactions of pyrrolo[3,4-b]indoles.
Indole alkaloids -- Synthesis. Diels-Alder reaction.
An efficient synthetic approach to both 2-acyl-1-(substituted)indoles and 2-nitro-1-(substituted)indoles by reaction of 2-lithio-1-(substituted)indoles with appropriate electrophiles is presented. Inverse quenching of 2-lithioindoles 5 and 208 with...
Dartmouth Dissertations

The role of the core-binding factor ß (CBFß) subunit in the CBF heterodimeric complex.
DNA-binding proteins. ; Transcription factors -- Structure. ; Genetic transcription -- Regulation.
Dartmouth Dissertations

Distinct neuroimmune interactions in acute inflammatory pain and persistent neuropathic pain.
Pain -- Immunological aspects. ; Inflammation -- Immunological aspects. ; Nervous system -- Diseases -- Immunological aspects. ; Neuroimmunology.
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
Dartmouth Dissertations

Functional analysis of the Runx1 C-terminal sequences.
Transcription factors. ; Hematopoiesis -- Regulation. ; Genetic transcription -- Regulation. ; DNA-binding proteins.
RUNX1 is a transcription factor regulating hematopoietic development. Study of the RUNX1 structure revealed two functional domains. The runt domain binds DNA and mediates interaction with CBFß. Sequences C terminal to the runt domain form the...
Dartmouth Dissertations

Characterizing the heterodimerization interface of core-binding factors (CBFs).
Transcription factors. DNA-protein interactions. Genetic transcription -- Regulation.
Core-binding factors (CBFs) are a small family of transcription factors that play important roles in several developmental processes and in human disease. CBFs consist of CBFα (Runx1, Runx2, or Runx3) and CBFβ. The CBFα subunit binds DNA in a...
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Investigation of Sec22p in ER to Golgi transport in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Membrane fusion. Biological transport -- Regulation. Cell membranes. Saccharomyces cerevisiae -- Cytology. Golgi apparatus. Endoplasmic reticulum.
Vesicle mediated intracellular transport through the secretory pathway requires the formation of transport vesicles from a donor compartment followed by vesicle tethering and fusion with an appropriate acceptor compartment. The anterograde...
Dartmouth Dissertations

Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
Dartmouth Dissertations

Insights into the assembly and organization of higher-order septin structures.
Septins. ; Proteins -- Structure. ; Fluorescence spectroscopy. ; Molecular biology -- Instruments. ; GTP-Binding Proteins.
Dartmouth Dissertations

Tumor necrosis factor contributes to early diabetic nephropathy.
Tumor necrosis factor. ; Diabetic nephropathies -- Pathogenesis. ; Renal tubular transport Disorders of.
Early renal changes during diabetes include sodium (Na) retention and renal hypertrophy. Tumor Necrosis Factor (TNF) is elevated during diabetes and is implicated in the pathogenesis of diabetic nephropathy. We tested the hypothesis that TNF...
Dartmouth Dissertations

Coupling of termination, 3' processing and mRNA export.
Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Solution structure determination of core binding factor ß(1-141) and map of CPFα binding site.
Transcription factors -- Structure. ; Genetic transcription. ; DNA-binding proteins.
Core binding factor (CBF) is a heterodimeric transcription factor that is essential for a number of developmental process including hemotopoiesis and bone development. CBFs contain a DNA-binding CBFα. subunit and a non-DNA binding CBFß. subunit...
Dartmouth Dissertations

Regeneration of neuromuscular connections from allotransplanted ganglia in the crayfish.
Ganglia, Sensory -- Transplantation. ; Central nervous system -- Regeneration. ; Procambarus clarkii -- Nervous system. ; Neurons -- Innervation. ; Synapses.
Dartmouth Dissertations

Structural and functional characterization of Runx1 point mutations identified in leukemia and cleidocranial dysplasia patients.
Transcription factors -- Pathophysiology. Hematopoiesis -- Genetic aspects. Genetic transcription -- Regulation. DNA-binding proteins. Leukemia -- Genetic aspects. Core Binding Factor Alpha 2 Subunit. Core Binding Factor beta Subunit. Cleidocranial...
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and...
Dartmouth Dissertations

The heterogeneous role of the medial prefrontal cortex and nicotinic acetylcholine receptor subtypes in negative occasion setting.
Prefrontal cortex -- Physiology. ; Acetylcholine -- Receptors. ; Nicotine -- Physiological effect. ; Inhibition.
Dartmouth Dissertations

Role of Erv14p in vesicle mediated protein transport from the endoplasmic reticulum to the Golgi in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Transport vesicles form at a donor compartment and fuse to an acceptor compartment mediate the movement of cargo proteins within eukaryotic cells from one subcellular compartment to another. COPII vesicles specifically provide the means of...
Dartmouth Dissertations

Catalytic asymmetric P-C bond formation with Pt-phosphido complexes.
Organoplatinum compounds -- Synthesis. Organoplatinum compounds -- Reactivity. Organophosphorus compounds -- Synthesis. Organophosphorus compounds -- Reactivity. Asymmetric synthesis. Phosphate carbon. Platinum catalysts.
Chapter One. Synthesis and Structure of Chiral Pt(Duphos) Terminal Phosphido Complexes. Treatment of Pt halide precursors with a secondary phosphine in the presence of the base NaOSiMe 3 gave the terminal phosphido complexes Pt(Duphos)(Ph)(PMeIs)....
Dartmouth Dissertations

Substrate and catalyst control in asymmetric synthesis of p-sterogenic bis(phosphines).
Introduction. This chapter provides a brief overview of the thesis. Chapter 1: tert-butyl-diphosphabutarene - Synthesis and reactivity of a novel phosphacycle. Treatment of 1,2-bis(dichlorophosphino)benzene (12) with tert-butylmagesium chloride...
Dartmouth Dissertations

Computational studies of small group IB clusters and their van der Waals complexes.
Transition metal complexes -- Spectra. ; Chemical reaction.
Dartmouth Dissertations

Investigation of the requirements for transitional endoplasmic reticulum (tER) site structure and function in Saccharomyces cerevisiae.
Endoplasmic reticulum.; Membrane proteins -- Physiological transport. ; Coated vesicles. ; Golgi apparatus. ; Saccharomyces cerevisiae -- Molecular aspects. ; Phospholipids -- Physiological effect. ; Saccharomyces cerevisiae Proteins. ; COP-Coated...
Eukaryotic cells contain distinct membrane-bound organelles that house sets of specialized metabolic reactions. The network of controlled communications between organelles is known as the secretory pathway. Transport of proteins and lipids between...
Dartmouth Dissertations

3D structure determination of reduced human glutaredoxin: Biophysical and biochemical characterization of CBFß proteins.
Transcription factors. ; Glutaredoxin -- Structure. ; DNA-protein interactions.
Dartmouth Dissertations

Multiple pathways for macromolecular transport through the nuclear pore complex in Saccharomyces cerevisiae.
Saccharomyces cerevisiae -- Genetics. ; Messenger RNA -- Genetic aspects. ; Proteins -- Synthesis. ; Heat shock proteins.
Dartmouth Dissertations

Investigation of the molecular mechanisms of Erv26p-dependent protein sorting.
Carrier proteins -- Molecular aspects. Membrane proteins -- Physiological transport. Proteins -- Secretion. Biological transport -- Regulation. Saccharomyces cerevisiae -- Molecular aspects. Endoplasmic reticulum. Golgi apparatus. Vesicular...
Studies of the secretory pathway have revealed a multitude of secretory proteins that depend on the coat protein complex II (COPII) for export from the endoplasmic reticulum (ER) in transport vesicles. Some secretory proteins require protein...
Dartmouth Dissertations

Metal-catalyzed asymmetric synthesis of P-stereogenic phosphines.
Phosphine. Phosphorus compounds -- Synthesis. Platinum catalysts. Palladium catalysts. Asymmetric synthesis. Enantiomers.
Abstract (Summary) Chapter One. Platinum-Catalyzed Asymmetric Alkylation of Bis(secondary) Phosphines. Efficient Screening and the Synthesis of an Enantiomerically Pure C 2 -Symmetric Diphosphine . Platinum-catalyzed asymmetric alkylation of...
Dartmouth Dissertations

Radical methodologies with indole and synthetic strategies towards the indole alkaloids, echitamine and prenostodione.
Indole alkaloids -- Synthesis. Ring formation (Chemistry). Radicals (Chemistry).
A novel radical cyclization of 2-bromoindoles was examined, generating a series of hexahydropyrrolo[3,4- b ]indoles in fair yield. This process involved the generation of a variety of indole-3-carboxamides followed by the introduction of bromine at...
Dartmouth Dissertations

Characterization of post-surgical immunity and memory responses to the poorly-immunogenic B16 melanoma.
T cells. Melanoma -- Immunotherapy. Immunologic memory. Immune response -- Regulation. Medical Term T-Lymphocytes, Regulatory -- immunology. CD8-Positive T-Lymphocytes -- immunology. Melanoma, Experimental -- immunology.
The potential for the immune system to control growing tumors was recognized over a century ago. Studies during the past 20 years have presented undisputable evidence that host T cells have the ability to recognize, and kill tumor cells. However,...
Dartmouth Dissertations

Characterization of novel cofactors for oncogenic transcription factors Myc and FoxM1 and cytotoxic peptides derived from an essential Myc domain.
Transcription factors -- Genetics. Carcinogenesis. Peptides. Cell cycle -- Regulation. Genetic regulation. Medical Terms: Genes, myc -- genetics; Forkhead Transcription Factors -- genetics; Neoplasm Proteins -- genetics; Trans-Activators --...
Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...
Dartmouth Dissertations

Single cycle terahertz pulse propagation in water.
Electromagnetic devices -- Design. Electromagnetic waves -- Transmission -- Measurement. Picosecond pulses. Water.
Single cycle electromagnetic pulses have been difficult to experimentally generate and to theoretically analyze. With the recent development of terahertz systems based on near infrared femtosecond lasers it has become possible to perform single...
Dartmouth Dissertations

Investigation of the influence of lipids in ER to Golgi transport.
Membrane proteins -- Physiological transport. Coated vesicles -- Physiology. Phospholipids -- Physiological effect. Inositol phosphates -- Physiological effect. Carrier proteins -- Molecular aspects. Golgi apparatus. Endoplasmic...
The secretory pathway in eukaryotic cells is responsible for the exocytic and endocytic pathways, as well as for the delivery of proteins and lipids from their sites of synthesis to the cell surface and the different compartments of the...
Dartmouth Dissertations

The involvement of anti-apoptotic Bcl-2 family proteins in vinblastine-induced apoptosis.
Therapeutics, Experimental. Leukemia -- Genetics. Leukemia -- Chemotherapy. Apoptosis. bcl2-Associated Death Protein. Vinblastine. Flavopiridol.
The efficacy of many chemotherapeutic agents can be attenuated by expression of the anti-apoptotic proteins Bcl-2, Bcl-X and Mcl-1. When ML-1 leukemia cells are incubated with vinblastine, they rapidly upregulate Mcl-1. Suppression of Mcl-1 with...
Dartmouth Dissertations

Effects of suburbanization on plant-pollinator interactions / by Adrian L. Carper.
Urban and suburban development is a dominant factor driving ecological processes at local and regional scales and its impacts on biodiversity and ecosystem services are alarming. Pollinators, especially bees, and the ecosystem services they...
Dartmouth Dissertations

Analysis of aberrant cell cycle regulation in pancreatic ductal adenocarcinoma uncovers novel thereapeutic approaches
Aberrant activation of cyclin D-Cdk4/6 is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly specific inhibitor for Cdk4 and Cdk6, exerted growth inhibitory effects on human PDAC cell lines....
Dartmouth Dissertations

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