The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
The proliferation of mobile devices and other consumer products has greatly expanded the market for CMOS image sensors. This in turn has promoted a trend of continued improvement in image sensor performance, as companies seek to gain an advantage...
The focus of this thesis is the study of nuclearity and exactness for groupoid crossed product C*-algebras. In particular, we present generalizations of two well-known facts from group dynamical systems and crossed products to the groupoid setting....
We begin with a result on the refocussing of null geodesics in space-times. We show that all oriented refocussing 2-dimensional Lorentz manifolds are also strongly refocussing. We also introduce a theory of virtual Legendrian knots. We show that...
Motivated by quantum mechanics and geometric optics, it is a long-standing problem whether the length spectrum of a compact Riemannian manifold can be recovered from its Laplace spectrum. One route to proving that the length spectrum depends on the...
Shape modeling is an important area in computer vision and medical imaging. Shape models have proved valuable in the tasks of object representation, recognition, and classification. This thesis focuses on shape models of 3D surfaces extracted from...
In this thesis, we consider several problems relating to cyclic subgroups of the group [mathematical equation]. Each element of [mathematical equation] has a unique representative in one of the two intervals [mathematical equation] and...
In this thesis we look at several problems that lie in the intersection between combinatorial and multiplicative number theory. A common theme of many of these problems are estimates for and properties of the smooth numbers, those integers not...
Microelectronics -- Design and construction. ; Micromachining. ; Strains and stresses. ; Silicon compounds.
This dissertation presents the use and extension of capabilities of surface machining technology, utilizing stress engineering between polysilicon and silicon nitride layers to build three-dimensional microstructures. A new theory and experimental...
This thesis constitutes the first steps in the author's program to investigate the question of when a homotopy of 2-cocycles Ï‰ = {Ï‰[subscript t]}[subscript tâˆŠ[0,1]] on a locally compact Hausdorff groupoid Æ“ induces an isomorphism of the...
Given graded C *-algebras A and B , we define the notion of an admissible pair ([straight phi], D ) for A and B . Associated to an admissible pair ([straight phi], D ) is an equivalence class of asymptotic morphisms from A to B . Under certain...
We present a number of findings concerning groupoid dynamical systems and groupoid crossed products. The primary result is an identification of the spectrum of the groupoid crossed product when the groupoid has continuously varying abelian...
In this thesis, we study the dynamics of magnetic flows on compact nilmanifolds. Magnetic flows are generalizations of geodesic flows. They model the motion of a particle of unit mass and unit charge in a smooth manifold M in the presence of a...
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
Friction severely limits performance in precise positioning systems. This thesis investigates one possible approach to counter friction related performance losses, friction cancellation. In this method a friction observer is used to estimate...
The mannose-sensitive hemagglutinin (MSHA) of Vibrio cholerae is a member of the family of type 4 pili. Type 4 pili expressed on the surface of a number of Gram-negative bacteria are often required for host colonization. MSHA is specifically...
5,6-Azulyne, the first azulyne to be prepared, has been trapped with furan to give an adduct whose crystal structure reveals marked bond alternation in the azulene pi system. The double bond in the furan moiety is responsible in part for the bond...
Evolutionary Computation (EC) is one of the most advanced computational techniques. It has been frequently and successfully used to find good solutions to many complicated optimization problems with limited computational resources. EC is the...
Our conscious experience of memory often includes reconstuctions of the past in order to fill the gaps of forgotten events and details. The goal of this thesis is to use the tools of cognitive neuroscience to better understand the cognitive and...
This thesis describes a new synthesis of substituted (3H)-1,2-dithiole-3-thiones (dithiolethiones) from readily available starting materials. Dithiolethiones have a wide variety of industrial and pharmaceutical applications. These include use as...
Antioncogenes. ; Breast -- Cancer -- Genetic aspects.
BRCA1 has been identified as a tumor suppressor gene that is mutated in many cases of inherited breast and ovarian cancer. Recent data suggest that multiple splice forms of BRCA1 exist, but the structure and function of these alternative...
The Border Gateway Protocol (BGP) that manages inter-domain routing on the Internet lacks security. Protective measures using public key cryptography introduce complexities and costs. To support authentication and other security functionality in...
Gene set testing has become a critical tool for interpreting the results of high-throughput genomic experiments. Despite the development of robust statistical methods and extensive gene set collections, however, the results from gene set testing...
Type 4 prepilins and prepilin-like-proteins are secreted by a wide range of bacterial species and are required for a variety of functions including type 4 pilus (Tfp) formation, toxin and other enzyme secretion, gene transfer, and biofilm...
A polynomial is a product of distinct cyclotomic polynomials if and only if it is a divisor over [Special characters omitted.] [x ] of xn - 1 for some positive integer n. In this thesis, we will examine two natural questions concerning the divisors...
Riemannian manifolds. Singularities (Mathematics). Laplacian operator. Spectral theory (Mathematics). Riemann surfaces. Curves on surfaces. Geometry
Historically, inverse spectral theory has been concerned with the relationship between the geometry and the spectrum of compact Riemannian manifolds, where spectrum means the eigenvalue spectrum of the Laplace operator as it acts on smooth...
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
CYP3A has the highest affinity for oxidation of Acetaminophen (APAP) with a Km close to the concentration observed in human serum after administration of therapeutic doses of APAP. CYP3A may be induced by numerous drugs as well as alcohols. We...
'The control of waves using periodic structures is crucial for modern optical, electromagnetic and acoustic devices such as diffraction gratings, filters, photonic crystals, solar cells, sensors, and absorbers. We present a high-order accurate...