The thermophilic anaerobic bacterium Clostridium thermocellum has attracted researchers attention because of its potential industrial application and high cellulose hydrolysis rates. This study focuses on the physiological fundamentals of C....
Chromium -- Toxicity testing. ; Glutathione. ; Vitamin C -- Physiological effect. ; Carcinogenesis. ; DNA damage.
Chromium(VI) is a human carcinogen and causes DNA damage following reduction by intracellular reductants. In order to explore the effects of intracellular reductants on the carcinogenicity of Cr(VI), the roles of glutathione and ascorbate in...
Arctic temperature and precipitation have been rising over recent decades, with implications for Greenland Ice Sheet (GrIS) mass balance, sea level rise, and thermohaline circulation via Arctic Ocean freshening. However, meteorological station data...
Hyperthermia, the elevation of tissue temperature from 42°C to 50°C, is currently being investigated as an adjunct to radiation therapy in the treatment of cancer. The interstitial microwave antenna array hyperthermia (IMAAH) system is designed...
Webster Daniel Paintings, Engravings, etc. (Includes Cartoons) 2
Webster Daniel Paintings, Engravings, etc. (Includes Cartoons) 2; receiced tax on 87, 86, 85, 84, 83, 82, 81 gall? distilled spirits; tax paid stamp; 80 gallons; B2032865; received this 30th day of 1887; from tax on 87 Galls. proof Spirit cash,...
Membrane docking and fusion are essential steps in intracellular vesicular trafficking. The underlying molecular mechanisms are highly conserved between organisms. Yeast homotypic vacuole fusion has become a paradigm in studying this fundamental...
Ultra high molecular weight polyethylene (UHMWPE) is the most common bearing material in joint arthroplasty due to its biocompatibility, its wear resistance, and its mechanical toughness. Despite the favorable properties of UHMWPE and its success...
Microelectronics -- Design and construction. ; Micromachining. ; Strains and stresses. ; Silicon compounds.
This dissertation presents the use and extension of capabilities of surface machining technology, utilizing stress engineering between polysilicon and silicon nitride layers to build three-dimensional microstructures. A new theory and experimental...
Hedgehog (HH) proteins play an important and evolutionary conserved patterning role in metazoan development. Aside from this physiological role, pathologically HH proteins are implicated in human developmental disorders and post-developmental...
Protein kinase C. Antigen presenting cells. Antigens -- Receptors. T cells -- Receptors. Major histocompatibility complex -- Genetic aspects. CD4-Positive T-Lymphocytes -- immunology. Histocompatibility Antigens Class II -- immunology. Receptors
Activation of CD4 T cells to exogenous antigens requires the formation and surface display of antigen-derived peptide-MHC class II complexes by antigen presentation cells. Acquisition of peptide by MHC class II is much studied, but the rules and...
Niemann-Pick Type C (NPC) disease is an autosomal, recessive, neurovisceral disorder associated with defects in cholesterol and glycolipid trafficking and metabolism, leading to the accumulation of cholesterol in the late endosomes and lysosomes....
Serotonergic and non-serotonergic neurons located in the medullary raphe region of the mammalian brainstem are involved in numerous physiological processes. Concerning respiration, neurons in this region have been found to be chemosensitive, i.e.,...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
Eukaryotic cells contain distinct membrane-bound organelles that house sets of specialized metabolic reactions. The network of controlled communications between organelles is known as the secretory pathway. Transport of proteins and lipids between...
Photodynamic therapy (PDT) is used to cause specific tissue destruction, using photochemical reactions that result from light excitation of photosensitizer, which has localized in the target tissue. The process of photosensitizer photobleaching was...
A sustainable energy future is critical for environmental and strategic reasons. One alternative to petroleum used for transportation is ethanol derived from cellulosic biomass. The major barrier for biomass conversion is a cost effective method...
Human behavior -- Mathematical models. ; Web usage mining. ; Internet users.
Whom we e-mail, where we browse, what we purchase, and the things we search for on the World Wide Web all leave identifiable traces of who we are as individuals. In today's technology focused landscape, cyberspace represents the new environment in...
Niemann-Pick type C (NPC) disease is a fatal autosomal recessive pediatric neurovisceral disorder characterized clinically by progressive neurodegeneration in the central nervous system (CNS) and hepatosplenomegaly. Biochemically, it is...