Dartmouth Digital Library Program

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Actions of substances placed in the cat cerebrospinal fluid space.
Pharmacology, Experimental. ; Cats.
Dartmouth Dissertations

Virulence and motility gene regulation in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. DNA-binding proteins. Genetic transcription -- Regulation. Promoters (Genetics)
The ctx and tcp genes that encode cholera toxin and the toxin co-regulated pilus, the major virulence determinants of Vibrio cholerae, are repressed by the nucleoid-associated protein H-NS and activated by the AraC-like transcriptional regulator...
Dartmouth Dissertations

Apoptosis as a mechanism of cell death by anticancer agents.
Apoptosis. Antineoplastic agents.
Dartmouth Dissertations

Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

Characterization of the role of Bacillithiol in Staphylococcus aureus / by Ana Catalina Posada.
As methicillin-resistant Staphylococcus aureus (MRSA) hospitalizations keep increasing, the understanding of the characteristics that make one isolate more successful over another is paramount. Strain variations among Staphylococcus aureus observed...
Dartmouth Dissertations

Characterization of spores and L-forms in C. Thermocellum and the identification of histidine kinases involved in spore formation through the use of established and novel genetic tools / by Elizabeth Barrett Mearls.
The expanding global population will need to look to alternative fuel sources in order to meet the increasing demand for transportation fuel, mitigate carbon emissions, and promote energy security. A promising alternative to traditional fossil...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

TGF-beta1 regulation of Th1 development and autoimmunity.
Transforming growth factors-beta. ; Th1 cells. ; Transcription factors. ; Autoimmunity. ; Cytokines. ; Immune response -- Regulation. ; T cells. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

Vibrio cholerae lipopolysaccharide peptide mimicry.
Endotoxins -- Immunology. Vibrio cholerae -- Immunology. Mimicry (Chemistry). Antigenic determinants. Peptides -- Immunology. Molecular mimicry -- immunology. Epitopes -- immunology.
The potential of peptide mimics of V. cholerae lipopolysaccharide (LPS) to elicit cross-reactive immune responses against LPS was investigated, as an alternative approach towards the development of a cholera vaccine. Peptide mimics of two...
Dartmouth Dissertations

Mechanisms of survival and persistence of Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Proteins -- Secretion. Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of the severe diarrheal disease cholera. Colonization of the host environment by V. cholerae requires the type IV toxin co-regulated pilus (TCP). Adequate colonization by V. cholerae is essential for cholera...
Dartmouth Dissertations

Identification of novel proteins involved in Vibrio cholerae motility.
Vibrio cholerae. Bacteria -- Motility. Flagella (Microbiology) -- Physiology. Membrane proteins.
Dartmouth Dissertations

Structural studies of Vibrio cholerae virulence gene regulators.
Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
Dartmouth Dissertations

Characterization of type IVb pilus components essential for functional TCP of Vibrio cholerae O395, including implications on the hierarchy of microcolony formation and virulence / by Jarrad Matthew Marles.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Virulence (Microbiology) -- Molecular aspects. ; Fimbriae Proteins.
Vibrio cholerae is the etiological agent of the acute intestinal disorder cholera. The source of cholera infection is typically fecal contamination of potable water sources. V. cholerae is able to colonize the host intestine and trigger the onset...
Dartmouth Dissertations

The Vibrio cholerae AraC-like protein ToxT: activation of tcpA expression and domain organization.
Vibrio cholerae -- Molecular genetics. Genetic transcription -- Regulation. Promoters (Genetics). DNA-binding proteins.
ToxT is a member of the AraC/XylS family of transcriptional regulators, and functions to activate expression of virulence genes in the intestinal pathogen Vibrio cholerae. The aim of this research was to investigate the mechanism of ToxT-dependent...
Dartmouth Dissertations

Mechanism of cleavage of the TcpA prepilin by the type 4 prepilin peptidase, TcpJ, of Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Peptidase -- Pathophysiology. ; Proteolytic enzymes.
Type 4 prepilins and prepilin-like-proteins are secreted by a wide range of bacterial species and are required for a variety of functions including type 4 pilus (Tfp) formation, toxin and other enzyme secretion, gene transfer, and biofilm...
Dartmouth Dissertations

Vibrio cholerae pathogenesis: molecular mechanisms of colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology). ; Cholera -- Pathogenesis. ; Pili (Microbiology).
Vibrio cholerae is a gram-negative bacterial pathogen that causes the severe diarrheal disease cholera. Several bacterial factors have been identified that are critical for V. cholerae intestinal colonization. The best characterized of these...
Dartmouth Dissertations

Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
Dartmouth Dissertations

Structural characterization of the LysR-type virulence factor, AphB, and insight into its mehcanism of transcriptional activation at the tcpPH promoter in Vibrio cholerae
The LysR-type virulence regulator, AphB, initiates the Vibrio cholerae virulence cascade resulting in expression of the two critical virulence factors, toxin-coregulated pilus and cholera toxin, by activating transcription at the tcpPH promoter....
Dartmouth Dissertations

Molecular analysis of mannose-sensitive hemagglutinin formation and toxin secretion by Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Hemagglutinin -- Analysis. ; Peptidase -- Pathophysiology.
The mannose-sensitive hemagglutinin (MSHA) of Vibrio cholerae is a member of the family of type 4 pili. Type 4 pili expressed on the surface of a number of Gram-negative bacteria are often required for host colonization. MSHA is specifically...
Dartmouth Dissertations

Dendritic cell Fcγ receptor expression and function
Fc receptors. Dendritic cells. Immune recognition.
Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

The immunobiology of antisecretory factor.
Monoclonal antibodies. ; Immunoglobulins. ; Immune response -- Regulation. Intestines -- Secretions.
Microglia are a bone marrow derived population of immune effector cells resident in the CNS. The function of these cells is manifold, and includes physiological, reparative, and immunological activities. During previous investigations of these...
Dartmouth Dissertations

Glucocorticoids affect the action of gamma interferon on human monocytes.
Glucocorticoids. ; Interferon. ; Monocytes. ; Immunity.
Dartmouth Dissertations

Vibrio cholerae H-NS: investigation of regulated genes and structure-function analysis.
Vibrio cholerae -- Genetics. ; DNA-binding proteins. ; Genetic transcription -- Regulation. ; Bacterial proteins.
H-NS, an abundant nucleoid associated protein, has a role in silencing the expression of a variety of environmentally regulated genes during growth under nonpermissive conditions. A genetic approach was used to study H-NS regulation of genes in...
Dartmouth Dissertations

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