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    • Structural studies of Vibrio cholerae virulence gene regulators.

    • Structural studies of Vibrio cholerae virulence gene regulators.
    • Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
    • Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
    • Mechanisms of Rab- and Rab effector-dependent membrane tethering, docking, and fusion.

    • Mechanisms of Rab- and Rab effector-dependent membrane tethering, docking, and fusion.
    • Membrane fusion. Membrane proteins -- Physiological transport. Yeast fungi -- Cytology. Medical Term Vacuoles -- metabolism. Cytoplasmic Vesicles -- metabolism rab GTP-Binding Proteins -- metabolism Proteolipids -- metabolism
    • Yeast vacuole fusion requires 4 SNAREs, the Rab GTPase Ypt7p, vacuolar lipids, the SNARE complex disassembly machinery Sec17p and Sec18p, and the heterohexameric HOPS complex. Vacuole fusion occurs in stages: cis-SNARE complexes (bound to one...
    • Vibrio cholerae lipopolysaccharide peptide mimicry.

    • Vibrio cholerae lipopolysaccharide peptide mimicry.
    • Endotoxins -- Immunology. Vibrio cholerae -- Immunology. Mimicry (Chemistry). Antigenic determinants. Peptides -- Immunology. Molecular mimicry -- immunology. Epitopes -- immunology.
    • The potential of peptide mimics of V. cholerae lipopolysaccharide (LPS) to elicit cross-reactive immune responses against LPS was investigated, as an alternative approach towards the development of a cholera vaccine. Peptide mimics of two...

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