Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical...
Nanoparticles have made significant advances in recent years in the realm of cancer therapy. These nanoparticles typically range in size from 10-250nm in diameter, allowing for differential systemic-based biodistribution. The enhanced permeability...
A new type of analytic expansion for use in stability calculations is presented and applied to the question of the stability of laminar solutions of the Navier-Stokes equation. This leads in a natural way to a model of the transition from laminar...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
This thesis presents two-fluid simulations of forced magnetic reconnection with finite electron inertia in two and three dimensional periodic systems. Reconnection in the system is driven by a spatially localized forcing function, added to the ion...
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Cataclysmic variable stars (CVs) are close, interacting binary systems comprised of a white dwarf and a companion star, which is typically a late-type dwarf star. Their progenitor systems are post common envelope binaries (PCEBs) with a white dwarf...
PDZ domains are protein:protein interaction domains that serve as molecular scaffolds, especially in the case of specialized cellular environments like polarized airway epithelial cells of the human lung. Historically the domains have been thought...
Regulatory linkage between epibiotic organisms and their host zooplankton populations is one of the least understood topics in zooplankton biology, despite the likely importance of epibionts to pelagic communities. These laboratory studies with...
Coherent states. Quantum field theory. Nonlinear theories.
In this thesis we study the properties of time-dependent, nontopological configurations and their effect on the macroscopic properties of a system described by a nonlinear field theory. These structures seem to be ubiquitous in relativistic field...
Magnetic nanoparticles are promising candidates for use in biomedical applications as remote sensors of biophysical properties, thermal therapy agents, and detectors of specific biomolecules. Many approaches have been used to model magnetic...
Boundary integral methods have long been used to solve boundary value problems for elliptic partial differential equations with piecewise constant coefficients, since they have several numerical advantages over conventional volume discretization....
Ecological and evolutionary implications of polymorphism and polyphenism in the asexual diapause of the rotifer Synchaeta pectinata from Star Lake, VT, were explored via field, laboratory, and theoretical investigations. S. pectinata is a...
Three-dimensional imaging in medicine -- Mathematical models. ; Stereoencephalotomy.
In the past, clinicians skilled at image-guided neurosurgery have relied solely on pre-operative scans for their navigational information. Often in the course of surgery, tissue is purposely retracted/resected or inadvertently moved resulting in a...
Cataclysmic variable stars are a broad class of close binary systems in which matter is transferred from a normal secondary star onto a white dwarf. This thesis reports spectroscopy of a number of examples, aimed mostly at clarifying the underlying...
We present results from a modeling effort of simple shock phenomena in the Cygnus Loop and Cassiopeia A. Using multi-epoch MDM observations of a small, isolated cloud in the southwest region of the Cygnus Loop, we measure the velocity of the...
Relativity (Physics). ; Anisotropy -- Mathematical models. ; Einstein field equations. ; Newtonian fluids. ; Astrophysics.
We study the effects of anisotropic pressure on the properties of spherically symmetric, gravitationally bound spheres. We consider the full general-relativistic and Newtonian treatment of this problem and obtain exact solutions for various forms...
Calanus finmarchicus -- Georges Bank. ; Calanus finmarchicus -- Maine Gulf of. ; Calanus finmarchicus -- North Atlantic Ocean.
Calanus finmarchicus, a kind of marine zooplankton, plays an important ecological role throughout the North Atlantic. Striking seasonal variations exist in its abundance and distribution in the Gulf of Maine/Georges Bank region. On the Bank in...