Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Niemann-Pick type C (NPC) is a neurovisceral disease that causes intracellular accumulation of cholesterol and other lipids. The exact mechanism how the defects in cholesterol trafficking pathways result in the progressive neurological damage is...
Since acyl Co-A: cholesterol acyltransferase (ACAT) is believed to be involved in important physiological functions such as lipoprotein assembly, cholesterol absorption, steroidogenesis, and pathogenesis of atherosclerosis, ACAT has been studied...
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
Cholesterol is essential for the survival of all mammalian cells. Mammalian cells obtain cholesterol via two pathways: it can be endogenously synthesized in the endoplasmic reticulum, or it can be obtained from exogenous sources, mainly through the...
In nematodes an alternative third larval stage, often called the dauer stage, allows the animals to weather periods of low food availability (if free living) or to disperse (if parasitic). Recently, studies of mutations in the nematode...
A hallmark of apoptosis is internucleosomal DNA fragmentation catalyzed by an endogenous endonuclease. Many laboratories have implicated the activation of Ca2+/Mg2+-dependent endonucleases or the acid-dependent deoxyribonucleases, (DNase II),...
Colloidal nanoparticles are particles with sizes ranging from one nanometer to several hundred nanometers, which disperse evenly in a dispersion medium. In aqueous solutions, amphiphilic molecules organize themselves to form such colloidal systems...
Since alkoxyamines, O-alkylated nitroxide derivatives, are important control agents for nitroxide-mediated polymerization, protocols for their synthesis should be straigh- forward, cost-effective, and versatile. We have utilized a facile method for...
Female reproductive tract (FRT) secretions contain a spectrum of cytokines, chemokines and antimicrobials that inhibit infection of target cells by HIV-1 and other sexually transmitted pathogens. Innate immune protection maintained by the presence...