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    • Investigation of the molecular mechanisms of Erv26p-dependent protein sorting.

    • Investigation of the molecular mechanisms of Erv26p-dependent protein sorting.
    • Carrier proteins -- Molecular aspects. Membrane proteins -- Physiological transport. Proteins -- Secretion. Biological transport -- Regulation. Saccharomyces cerevisiae -- Molecular aspects. Endoplasmic reticulum. Golgi apparatus. Vesicular...
    • Studies of the secretory pathway have revealed a multitude of secretory proteins that depend on the coat protein complex II (COPII) for export from the endoplasmic reticulum (ER) in transport vesicles. Some secretory proteins require protein...
    • Mechanisms of Rab- and Rab effector-dependent membrane tethering, docking, and fusion.

    • Mechanisms of Rab- and Rab effector-dependent membrane tethering, docking, and fusion.
    • Membrane fusion. Membrane proteins -- Physiological transport. Yeast fungi -- Cytology. Medical Term Vacuoles -- metabolism. Cytoplasmic Vesicles -- metabolism rab GTP-Binding Proteins -- metabolism Proteolipids -- metabolism
    • Yeast vacuole fusion requires 4 SNAREs, the Rab GTPase Ypt7p, vacuolar lipids, the SNARE complex disassembly machinery Sec17p and Sec18p, and the heterohexameric HOPS complex. Vacuole fusion occurs in stages: cis-SNARE complexes (bound to one...
    • Protein spatial dynamics during homotypic vacuole fusion.

    • Protein spatial dynamics during homotypic vacuole fusion.
    • Membrane proteins -- Physiological transport. ; Membrane fusion. ; Tonoplasts. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Molecular aspects.
    • Membrane docking and fusion are essential steps in intracellular vesicular trafficking. The underlying molecular mechanisms are highly conserved between organisms. Yeast homotypic vacuole fusion has become a paradigm in studying this fundamental...

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