Dartmouth Digital Library Program

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Implementation, characterization, and applications of a scanning Kelvin probe force microscope.
Scanning force microscopy. Scanning electron microscopes -- Design and construction. Semiconductors -- Analysis.
Dartmouth Dissertations

Understanding inpatient nurses' engagement in worksite health promotion: a case study.
Nurses -- Health and hygiene. Employee health promotion.
Background. Worksite health promotion programs (HPP) support employees' health behaviors to prevent downstream diseases. Maximizing participation can optimize program impact. Objectives. To assess staff nurses' participation in three HPP - flu...
Dartmouth Dissertations

Characterization of Saccharomyces cerevisiae genes RAT8, RAT9/NUP85 and RAT10/NUP145.
Messenger RNA -- Physiological transport. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

FGF2 in endothelial cell migration, intracellular signalling and receptor endocytosis.
Fibroblast growth factors. Rho GTPases. Cell receptors. Integrins -- Physiological effect. Endocytosis. Vascular endothelium. Cellular signal transduction.
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
Dartmouth Dissertations

Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations

Environmental and climatic controls on glaciochemistry of near-surface snow in Greenland / by Gifford J Wong
Arctic temperature and precipitation have been rising over recent decades, with implications for Greenland Ice Sheet (GrIS) mass balance, sea level rise, and thermohaline circulation via Arctic Ocean freshening. However, meteorological station data...
Dartmouth Dissertations

Eisosomes organize the plasma membrane of yeast / by Ruth V. Kabeche
The cortical cytoskeleton mediates a range of cellular activities such as endocytosis, cell motility, and the maintenance of cell rigidity. In yeast cells, prominent cortical structures called eisosomes generate specialized domains termed MCCs to...
Dartmouth Dissertations

Regulation of dendritic cell biology in vitro and in vivo with biological response modifiers.
Dendritic cells. Biological response modifiers. Immune response -- Regulation. T cells. CD antigens. Dendritic Cells -- Immunology. Receptors
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that regulate antigen-specific T cell activation or tolerance. The maturation state of DCs is critical since immature DCs are believed to induce T cell tolerance whereas mature...
Dartmouth Dissertations

Self-esteem and biases in the processing of threat and rejection stimuli.
Self-esteem. ; Rejection (Psychology). ; Threat (Psychology). ; Failure (Psychology). ; Memory -- Psychological aspects.
Prior research has shown that people with high and low self-esteem respond differently to rejection and failure. These differential responses may be due to the expectations people hold about their future acceptance by others and may be linked to...
Dartmouth Dissertations

Discovery of new NAD+ metabolic pathways and nutritional regulation.
NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Phosphatases. Phosphates -- Metabolism -- Regulation. Medical Term Nucleotidases -- metabolism. Nicotinamide-beta-riboside.
Nicotinamide adenine dinucleotide (NAD+) is classically known as an essential co-enzyme for hydride transfer reactions in metabolism. More recently, it has been recognized as a consumed substrate of ADPribose transfer enzymes...
Dartmouth Dissertations

Diffuse tomography of absorbing and fluorescent optical exogenous contrast guided by simultaneously acquired magnetic resonance images.
Optical tomography. Fluorescence. Imaging systems -- Design and construction. Diagnostic imaging -- Mathematical models. Brain -- Diseases -- Diagnosis. Brain -- Magnetic resonance imaging.
Fluorescent molecules targeted to reveal information on tissue function have been used as research tools in ex vivo and subsurface characterization of diseased tissue for years. Exploiting this specificity for in vivo imaging through centimeters of...
Dartmouth Dissertations

In vivo degradation in modern orthopaedic UHMWPE bearings and structural characterization of a novel alternative UHMWPE material / by Steven D. Reinitz.
Ultra-high molecular weight polyethylene (UHMWPE) remains the most common bearing material for total joint arthroplasty. Advances in radiation cross-linking and other post-consolidation treatments have led to a rapid differentiation of polyethylene...
Dartmouth Dissertations

Nucleophilic addition to electron deficient indoles and the synthesis of fused heterocyclic ring systems.
Indole -- Synthesis. ; Heterocyclic compounds -- Synthesis.
The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
Dartmouth Dissertations

Nuclear receptor corepression, negative feedback and transcription-based oscillation: Evidence for a novel form of nuclear receptor regulation.
Nuclear receptors (Biochemistry) Retinoids -- Receptors. Genetic regulation. Medical Term Receptors, Cytoplasmic and Nuclear -- genetics Receptors, Retinoic Acid -- genetics.
Nuclear receptors (NRs) are ligand-regulated transcription factors that control gene expression through interaction with coregulator proteins. Receptor interacting protein 140 (RIP140) is a ligand-inducible, ligand-dependent NR corepressor with...
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
Dartmouth Dissertations

Vibrio cholerae lipopolysaccharide peptide mimicry.
Endotoxins -- Immunology. Vibrio cholerae -- Immunology. Mimicry (Chemistry). Antigenic determinants. Peptides -- Immunology. Molecular mimicry -- immunology. Epitopes -- immunology.
The potential of peptide mimics of V. cholerae lipopolysaccharide (LPS) to elicit cross-reactive immune responses against LPS was investigated, as an alternative approach towards the development of a cholera vaccine. Peptide mimics of two...
Dartmouth Dissertations

Structural studies of Vibrio cholerae virulence gene regulators.
Vibrio cholerae -- Molecular genetics. ; Virulence (Microbiology) -- Molecular aspects. ; Genetic regulation. ; Viral proteins.
Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. The disease is acquired by oral ingestion of contaminated water or food. In order for Vibrio cholerae to cause the disease cholera, it must produce two important...
Dartmouth Dissertations

Biochemical characterization of prion conversion.
Prion diseases. Prions. Proteolytic enzymes -- Pathophysiology. Proteins -- Conformation.
Prion diseases are infectious neurodegenerative disorders characterized by a conformational change of the host-encoded prion protein. The normal nonpathogenic isoform of the prion protein (PrPc) is primarily composed of α-helices and very low...
Dartmouth Dissertations

On the poisson relation for lens spaces / by Donato R. Cianci
Motivated by quantum mechanics and geometric optics, it is a long-standing problem whether the length spectrum of a compact Riemannian manifold can be recovered from its Laplace spectrum. One route to proving that the length spectrum depends on the...
Dartmouth Dissertations

Three factors influencing physical health in serious mental illness:smoking, health education, and employment
The confluence of patient, provider, and system level factors contributes to excess mortality due to preventable medical conditions among people with serious mental illness (SMI) compared to the general population. Study one explored how...
Dartmouth Dissertations

A framework of computational opinions / by Fei Yu.
We have a limited understanding of how an opinion is originated, how an opinion and information supporting and explaining it gets conveyed, and how the communicated opinion is perceived and processed by others. One direction of current research...
Dartmouth Dissertations

Neural and behavioral correlates of auditory-object processing.
Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Dartmouth Dissertations

Cognitive and neural mechanisms of social motivation / by Katherine E. Powers.
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
Dartmouth Dissertations

Reward and self-regulation in online digital environments.
Reward (Psychology). ; Self-control. ; Internet addiction -- Physiological aspects. ; Behavior Addictive -- pathophysiology.
The motivational and rewarding properties of our immediate environment affect how humans interact with our world in a number of ways. One important aspect in which reward representation shapes behavior is in the development, maintenance and...
Dartmouth Dissertations

On the modeling of seasonal variation in the three-dimensional circulation near Georges Bank.
Ocean circulation -- Effect of seasons on -- Georges Bank. ; Ocean circulation -- Georges Bank -- Mathematical models.
Dartmouth Dissertations

Computer modeling of total hip replacement : application to joint geometry stress analysis and bone remodeling
Total hip replacement -- Computer simulation.
Dartmouth Dissertations

Historical and functional ecology of rainforest foragers / by Vivek V. Venkataraman
This dissertation examines the behavioral and physiological adaptations employed by modern humans to subsist in tropical rainforests. I employ various theoretical and methodological approaches to test hypotheses using empirical data from African...
Dartmouth Dissertations

An EPR spectroscopic investigation of paramagnetic organometallic complexes.
Organometallic compounds. ; Paramagnetism. ; Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

Tracing the retention and redistribution of lead and other atmospheric fallout in soils.
Soils -- Lead content -- New Hampshire. ; Soils -- Lead content -- Vermont. ; Lead -- Environmental aspects -- New Hampshire. ; Lead -- Environmental aspects -- Vermont. ; Atmospheric deposition -- Environmental aspects -- New Hampshire. ; ...
A basic understanding of how atmospherically-derived elements behave in soils is of concern in contaminant transport, nutrient cycling, and carbon sequestration studies. Here, I use stable and radioactive tracers to evaluate the fate of...
Dartmouth Dissertations

Molecular and biochemical studies on human ACAT genes and proteins.
Acyltransferases -- Genetic aspects. ; Genetic transcription. ; Enzymatic analysis.
Since acyl Co-A: cholesterol acyltransferase (ACAT) is believed to be involved in important physiological functions such as lipoprotein assembly, cholesterol absorption, steroidogenesis, and pathogenesis of atherosclerosis, ACAT has been studied...
Dartmouth Dissertations

SHEMP: secure hardware enhanced MyProxy.
Public key infrastructure (Computer security). ; Computer networks -- Security measures. ; Operating systems (Computers). ; Microcomputers.
In 1976, Whitfield Diffie and Martin Hellman demonstrated how public key cryptography could enable secure information exchange between parties that do not share secrets. In order for public key cryptography to work in modern distributed...
Dartmouth Dissertations

Forming, operating, and improving micro-systems of health care.
Clinical medicine -- Practice. ; Medicine -- Practice. ; Group medical practice.
Health care micro-systems are small, organized groups of clinicians and staff working together with a shared clinical purpose to provide care for a defined set of patients. The size of individual micro-systems vary--a micro-system must be large...
Dartmouth Dissertations

Dartmouth magnetic evolutionary stellar tracks and relations / by Gregory Alexander Feiden.
Strong evidence exists showing that stellar evolution models are unable to accurately predict the fundamental properties of low-mass stars. Observations of low-mass stars in detached eclipsing binaries (DEBs) indicate that stellar models...
Dartmouth Dissertations

Synthetic studies directed toward investigation of cholesterol regulation.
Cholesterol -- Synthesis -- Regulation. ; Anticholesteremic agents -- Synthesis. ; Squalene.
Chapter II of this thesis describes the synthesis of a number of sulfobetaines and bissulfobetaines to be evaluated as inhibitors of squalene synthase (SS) on the basis of the idea proposed by Shechter that their zwitterionic structure would be...
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

Intrinsic photoconductivity in molecular crystals,
Crystals -- Electric properties.; Photoconductivity.
Dartmouth Dissertations

The influence of shared mental models of nosocomial bloodstream infections on neonatal intensive care unit infection rates.
Neonatal infections -- Prevention. Nosocomial infections -- Prevention. Neonatal intensive care -- Social aspects. Neonatal intensive care -- Psychological aspects.
Statement of the problem. Nosocomial bloodstream infections (NBSIs) are a significant source of morbidity and mortality for the very low birth weight babies (VLBW) in neonatal intensive care units (NICUs). Efforts to reduce the rates of infection...
Dartmouth Dissertations

Dynamics of magnetic flows on nilmanifolds / by Jonathan Epstein
In this thesis, we study the dynamics of magnetic flows on compact nilmanifolds. Magnetic flows are generalizations of geodesic flows. They model the motion of a particle of unit mass and unit charge in a smooth manifold M in the presence of a...
Dartmouth Dissertations

The effects of self-disclosure of emotional reactions on arousal : does what we talk about make a difference?
Self-disclosure. ; Arousal (Physiology). ; Emotions
Dartmouth Dissertations

Mechanisms of feeling of knowing in memory.
Memory -- Testing. ; Psychology Experimental.
Dartmouth Dissertations

Spontaneous and stimulated Smith-Purcell radiation experiments in the far-infrared.
Infrared radiation -- Experiments. ; Diffraction gratings -- Experiments.
Dartmouth Dissertations

RR Lyrae stars as tracers of stellar populations in the Galactic bulge and satellite galaxies.
RR Lyrae stars. Milky Way. Stars -- Populations.
This dissertation details the use of a new catalog of Galactic bulge field RR Lyrae variables to advance the understanding of the structure of the Milky Way Galaxy. The catalog contains 3667 RR0 Lyrae stars from the eight-year MACHO Project...
Dartmouth Dissertations

Molecular characterisation of microtubule dependent organelle motility in the squid giant axon and optic lobe.
Axonal transport. ; Kinesin. ; Mitochondria. ; Microtubules. ; Optic lobes. ; Squids.
Dartmouth Dissertations

The neural assembly of place cells and head direction cells.
Limbic system -- Psychophysiology. ; Neuropsychology. ; Cell interaction.
Previous research has identified neurons in a variety of limbic structures which discharge in relation to the animals ongoing head direction (HD) (Ranck 1984; Taube et al. 1990a) or location (O''Keefe & Dostrovsky 1971). Because these signals...
Dartmouth Dissertations

Nd, Sr and O isotopic study of midcrustal granitoid petrogenesis within the Acadian central Maine terrane.
Petrology -- Maine. Granite -- Maine. Isotope geology -- Maine.
Dartmouth Dissertations

Nonstigmatized individuals' reactions to the acknowledgment and valuation of a stigma by overweight individuals and physically disabled individuals.
Overweight persons -- Attitudes. ; People with disabilities -- Attitudes. ; Obesity -- Public opinion. ; Stigma (Social psychology). ; Self-presentation.
In the last few years, a new perspective on the management of obesity has emerged. Instead of focusing on dieting and weight loss efforts, the new approach focuses on size acceptance. The concept of positively accepting one's deviant features has...
Dartmouth Dissertations

Molecular cloning and analysis of arg-13, os-1 and prd-4 in Neurospora crassa.
Molecular cloning. ; Circadian rhythms. ; Neurospora crassa.
Dartmouth Dissertations

Magnet hospitals and patient outcomes.
Nursing services -- United States -- Evaluation. Nursing services -- United States -- Personnel management. Hospitals -- United States -- Administration. Outcome assessment (Medical care). Nursing Service.
Dartmouth Dissertations

Representation of auditory and visual spatial information in the intraparietal sulcus of rhesus macaques.
Auditory perception -- Physiological aspects. ; Visual perception -- Physiological aspects. ; Auditory pathways -- Physiology. ; Parietal lobes -- Psychophysiology. ; Saccadic eye movements.
The integration of visual and auditory events is thought to require a joint representation of visual and auditory space in a common reference frame. We investigated the coding of visual and auditory space in the lateral and medial intraparietal...
Dartmouth Dissertations

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