Dartmouth Digital Library Program

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Geographic variation in the supply and use of inpatient post-acute care and its association with orthopedic surgery.
Hospitals -- After care -- United States. Medicare beneficiaries -- Hospital care -- Costs. Geriatric orthopedics -- Economic aspects. Health services accessibility -- United States. After care -- supply & distribution -- United States.
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Effects of mesencephalic reticular formation and mesencephalic auditory pathway lesions on long- and short-term habituation processes in the rat.
Habituation (Neuropsychology) Mesencephalon. Rats as laboratory animals.
Dartmouth Dissertations

The employment of people with severe mental illness / by Alison E. Luciano.
Study 1 This systematic review aimed to synthesize the emerging body of work on the impact of employment, with a focus on prospective cohort studies. Researchers identified relevant studies for review via PubMed, expert referral, and reference...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Learning, retention and transfer in backward masking.
Masking (Psychology). Memory. Learning.
Dartmouth Dissertations

Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations

Contributions of retrosplenial cortex to associative learning and memory.
Cerebral cortex -- Psychophysiology. Learning.
Neuroanatomical studies have defined two relatively separate corticohippocampal processing streams that contribute substantially to medial temporal lobe function. Among the cortical regions providing significant input to these processing streams is...
Dartmouth Dissertations

The role of CD40 in cutaneous and regional immune responses.
CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
Dartmouth Dissertations

Decision-analytic approaches to optimizing use of medical tests: methods and applications.
Clinical medicine -- Decision making -- Mathematical models. ; Diagnosis Laboratory. ; Medical screening -- Mathematical models. ; Osteoporosis -- Diagnosis. ; Mycobacterial diseases -- Diagnosis.
This dissertation focuses on the use of decision analysis to study the optimal use of medical tests. The classic threshold model of clinical decision making provides methodological background and motivation for the dissertation. In this model,...
Dartmouth Dissertations

Providing evidence and measurement tools to support health care reform in communities.
Community health services -- United States -- Evaluation. ; Health care reform -- United States. ; Medical care -- United States -- Evaluation. ; Evidence-based medicine.
Dartmouth Dissertations

Mechanisms of the nephrotoxicity of acetaminophen studied in the mouse kidney cortex slice system.
Renal pharmacology. ; Acetaminophen. ; Mice -- Physiology.
Dartmouth Dissertations

Self-reconfiguring robots: designs, algorithms, and applications.
Robots -- Control systems. ; Robots -- Motion. ; Computer algorithms. ; Electronic data processing -- Distributed processing.
Self-reconfiguring robots are robots composed of many physically connected modules which can change their structural configuration to support multiple functionalities. We claim that self-reconfiguring robots are more versatile, extensible, and...
Dartmouth Dissertations

Geographic access, utilization, and outcomes in lung, breast, prostate, and colorectal cancer patients at NCI-designated cancer centers.
Cancer Control Program (National Cancer Institute) -- Evaluation. Cancer -- Treatment -- United States -- Evaluation. Cancer -- Patients -- Care -- Evaluation.
Background. Disparities in access to cancer care and cancer-related outcomes have been demonstrated in the U.S. Patterns of access to National Cancer Institute-designated Cancer Centers (NCI-CCs), the most specialized cancer care settings, have not...
Dartmouth Dissertations

Budding yeast discovery tools for neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to a variety of benign and malignant nervous system tumors. NF1 is caused by a mutation in the NF1 tumor suppressor gene, which encodes neurofibromin, a...
Dartmouth Dissertations

Analysis of inpatient surveillance data for automated classification of deterioration.
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Dartmouth Dissertations

Characterization of molecular subsets of scleroderma using pathway analysis and animal models.
Scleroderma (Disease) -- Genetic aspects. Scleroderma (Disease) -- Molecular aspects. Cytokines -- Pathophysiology. Gene expression. Cellular signal transduction.
Scleroderma (systemic sclerosis; SSc) is a devastating autoimmune disease of unknown etiology for which there is no cure, and no truly effective therapies available. Immune dysfunction, fibrosis and vasculopathy are the three major features of the...
Dartmouth Dissertations

Genetic variants among G-protein coupled receptors and implications for cardiovascular disease.
G proteins -- Receptors. Cardiovascular system -- Diseases -- Genetic aspects. Medical Term Receptors, G-Protein-Coupled -- genetics.
Single-nucleotide polymorphisms (SNPs), particularly non-synonymous variants, provide opportunities for deciphering pathophysiological protein influence. An ideal group for realizing these opportunities is the GPCR-superfamily. Principles from...
Dartmouth Dissertations

Gene expression subsets and biomarkers in the genome-wide expression profiles of systemic sclerosis.
Systemic scleroderma -- Genetic aspects. Gene expression.
Systemic sclerosis (SSc) is an autoimmune disease with a heterogeneous range of skin and internal organ involvement, a progressive course, incompletely understood pathogenesis, and unpredictable outcome. The disease is most known for varying...
Dartmouth Dissertations

A reciprocal relationship between Scavenger Receptor-A and toll-like receptor 4 in bacterial phagocytosis and endotoxic shock resistance.
Cell receptors. Phagocytosis -- Immunological aspects. Septic shock -- Immunological aspects. Bacterial diseases -- Immunological aspects. Natural immunity. Medical Term Receptors, Cell Surface -- physiology. Toll-Like Receptors -- physiology.
An organism's long-term survival is critically dependent on its ability to protect itself from pathogenic microbial infections. The first line of defense against such infections is the branch of the immune response referred to as the innate immune...
Dartmouth Dissertations

Eliciting patients' preferences for the intensity of preference-sensitive health care: An integrated research strategy.
Patients -- Decision making. Patients -- Attitudes. Motivation (Psychology) -- Social aspects. Preferences (Philosophy) Medical care -- Evaluation. Medical care -- Research -- Methodology. Medical care -- Decision making.
Statement of Problem Characterizing the public's preferential attitudes towards relatively more-/less-intense elective options in ""preference-sensitive"" health care situations is particularly relevant for the prioritization policies of...
Dartmouth Dissertations

Modifiable factor relationships with biopsychosocial disability in multiple sclerosis
Modifiable Factor Relationships with Biopsychosocial Disability in Multiple Sclerosis Brant J. Oliver Problem Statement: Multiple sclerosis (MS) is a chronic disease of the central nervous system and is among the most common neurological...
Dartmouth Dissertations

Photo forensics from partial constraints / by Eric Lee.
A variety of forensic methods have been developed to identify falsified photos, each unified by the ability to estimate and detect properties of a photo that are perturbed by forgery. There exist, however, many photos in which the required...
Dartmouth Dissertations

Advancement of magnetic resonance poroelastography for applications in brain imaging / by Adam J. Pattison.
Brain tissue mechanics are an important biomarker for neurological disorders, yet methods to obtain tissue information yield inconsistent conclusions. These techniques can be invasive or require excised tissue, where tissue function is altered from...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Utilization and health outcomes in a spatial model of the US health care system / by Laura C. Yasaitis.
Objectives: This dissertation comprises three essays on geographic variations in healthcare, and the association between utilization and health outcomes. I first explore associations between outpatient visits and Medicare beneficiaries'...
Dartmouth Dissertations

Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Dartmouth Dissertations

Intrinsic photoconductivity in molecular crystals,
Crystals -- Electric properties.; Photoconductivity.
Dartmouth Dissertations

Physical disability and the attribution dilemma : perceiving the causes of behavior in social interaction
People with disabilities -- Psychology; Social perception
Dartmouth Dissertations

C.O.A.L.1: a dynamic model for the analysis of United States energy policy.
Energy policy -- United States -- Mathematical models.
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
Dartmouth Dissertations

Spectroscopic analyses of type Ia supernovae / by Jerod Parrent.
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
Dartmouth Dissertations

Access control in and for the real world / by Sara Sinclair.
Access control is a core component of any information-security strategy. Researchers have spent tremendous energy over the past forty years defining abstract access-control models and proving various properties about them. However, surprisingly...
Dartmouth Dissertations

Characterization of an inducible model of a genetic prion disease in Drosophila melanogaster / by Archana Murali.
Prion diseases are progressive disorders that affect the central nervous system leading to memory loss, personality changes, ataxia and neurodegeneration. In humans, these disorders include Creutzfeldt-Jakob disease, kuru and...
Dartmouth Dissertations

Role of the Menin-MLL1 interaction in normal hematopoiesis and leukemia / by Bin Li.
Leukemia represents a small percentage of human cancer, accounting for about 5% of all cases of cancer in adults, but, interestingly, for about 50% of all cases of cancer in children. The behavior of leukemia is often regulated by the chromosomal...
Dartmouth Dissertations

Temperature effects on food web interactions : from lakes to landscapes / by Samuel Butler Fey.
Temperature has powerful effects on all scales of biological organization from biochemical reactions to ecosystem processes. Despite the well-appreciated influence and thorough understanding of the physiological and population consequences of...
Dartmouth Dissertations

Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Dartmouth Dissertations

Cognitive and neural mechanisms of social motivation / by Katherine E. Powers.
The need for social connection is a pervasive and powerful human drive. When this fundamental need is not fulfilled, people place greater emphasis on forming social bonds and are motivated to behave in ways consistent with accomplishing these...
Dartmouth Dissertations

MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

Late glacial and holocene fluctuations of local glaciers and the Greenland Ice Sheet eastern and western Greenland / by Laura B. Levy.
The Greenland Ice Sheet (GrIS) is responding sensitively to climate change and its meltwater has the potential to influence global sea level. Recently, large changes in the GrIS have occurred including increased velocities of outlet glaciers and...
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
Dartmouth Dissertations

The role of hypoxia and hypoxia inducible factor 1 Alpha in Aspergillus fumigatus-host pathogenesis / by Kelly M. Shedardson.
Advances in medicine such as organ transplantations and cancer therapies involve the use of immunosuppressant drugs have led to rises in at risk patients and invasive fungal infections (IFIs). The filamentous fungus Aspergillus fumigatus is the...
Dartmouth Dissertations

SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations

Targeting CFTR endocytic interactions as a therapeutic strategy in cystic fibrosis / by Lemira Sahar Al Ayyoubi.
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

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