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- Vasopressin gene expression by non-neuronal cells: production in the gastrointestinal system and neoplasms of the lung.
- Vasopressin. ; Gene expression. ; Gastrointestinal system. ; Lungs -- Cancer. ; Immunocytochemistry.
- Dartmouth Dissertations
- Th-dependent B cell activation.
- B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
- Dartmouth Dissertations
- Hepatic T cells and MDSCs in TGF-ß1-deficient mice.
- Chronic active hepatitis -- Pathogenesis. ; Suppressor cells. ; Transforming growth factors-beta. ; CD4-Positive T-Lymphocytes -- immunology. ; Transforming Growth Factor beta1 -- immunology.
- Autoimmune hepatitis (AIH) is an autoimmune liver disease characterized by immune-mediated necroinflammatory liver damage associated with CD4 + T cell infiltration in liver parenchyma. Despite advances in the understanding of AIH, its etiology...
- Dartmouth Dissertations
- The role of CD40 in cutaneous and regional immune responses.
- CD antigens. ; Immune response -- Regulation. ; T cells -- Receptors. ; Antigens CD40. ; Lymphoma.
- Dartmouth Dissertations
- The role of core binding factor in the pathogenesis of the Moloney murine leukemia virus.
- Retroviruses -- Pathogenesis. ; Virus diseases -- Pathogenesis. ; Genetic transcription -- Regulation. ; Viral genetics. ; Mouse leukemia viruses.
- Dartmouth Dissertations
- Studies on the mode of action of glucocorticoids in islated rat tymus cells: investigations into the latency and site of corticol inhibition of glucose uptake and glucose 6-phosphate accumulation.
- Glucocorticoids.
- Dartmouth Dissertations
- Hypertonicity and mitogenic activation of lymphocytes.
- Lymphocytes. ; DNA -- Synthesis. ; Mitogens.
- Dartmouth Dissertations
- Synthesis, structure, and reactivity of cationic palladium secondary phosphine complexes.
- Phosphine. ; Organophosphorus compounds -- Synthesis. ; Transition metal compounds. ; Complex compounds.
- Dartmouth Dissertations
- Apoptosis as a mechanism of cell death by anticancer agents.
- Apoptosis. Antineoplastic agents.
- Dartmouth Dissertations
- Hematopoiesis in the allantois and chorion.
- Hematopoietic stem cells. ; Transcription factors. Placenta -- Cytology. Chorion -- Cytology. ; Cellular signal transduction.
- The placenta is the extra-embryonic tissue that mediates the exchange of oxygen and nutrients between the fetus and mother. It was shown that the placenta is a source of hematopoietic stem cells (HSCs). However, it is not known whether the placenta...
- Dartmouth Dissertations
- The role of mitochondria in chromium carcinogenesis.
- Chromium. Carcinogens. ; Mitochondria.
- Dartmouth Dissertations
- Functional heterogeneity and helper roles of CD4+T cells in antiviral immunity / by Zhuting Hu
- CD4+ T cells are critical for the control of virus infections, memory cell formation and immune surveillance. Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus are two γ-herpesviruses identified in humans and are strongly associated...
- Dartmouth Dissertations
- Fibroblast gene expression in proliferative connective tissue disease.
- Fibroblasts. ; Gene expression. ; Rheumatoid arthritis. ; Scleroderma (Disease).
- Dartmouth Dissertations
- An effective distributed caching strategy for partial result reuse for discrete optimization problems.
- Evolutionary computation. ; Cache memory. ; Mathematical optimization. ; Protein folding -- Computer simulation.
- Evolutionary Computation (EC) is one of the most advanced computational techniques. It has been frequently and successfully used to find good solutions to many complicated optimization problems with limited computational resources. EC is the...
- Dartmouth Dissertations
- Characterization of the molecular mechanism by which arsenic and chromium alter inducible gene expression.
- Arsenic -- Mechanism of action. ; Arsenic -- Toxicology. ; Chromium -- Mechanism of action. ; Chromium -- Toxicology. ; Gene expression.
- Metals are ubiquitous in our environment. Through evolution, many biological processes have taken advantage of and have become dependent on specific metals for various biochemical functions. Metals can also be toxic to biological systems at...
- Dartmouth Dissertations
- Immunomodulation and the prevention of pathogen-driven ileitis.
- Crohn's disease -- Prevention. Crohn's disease -- Treatment. Immune response -- Regulation. Toxoplasma gondii -- Pathophysiology.
- Oral infection with Toxoplasma gondii in susceptible C57BL/6 mice results in the morphologic, histologic and immunologic changes in the small intestine consistent with the human Inflammatory Bowel Disease (IBD) of unknown etiology, Crohn's disease....
- Dartmouth Dissertations
- Glucocorticoid receptor phosphorylation through the cell cycle.
- Glucocorticoids -- Receptors. ; Phosphorylation.
- Dartmouth Dissertations
- The role of Mediator and TFIIH in CTD-dependent transcription.
- Saccharomyces cerevisiae -- Genetics. ; Genetic transcription -- Regulation. ; RNA -- Genetic aspects.
- The C terminal domain (CTD) of Rpb1, a sub-unit of RNA Pol II, in Saccharomyces cerevisiae, contains 26 repeats of a heptapeptide sequence that is highly conserved in all eukaryotes. The CTD affects the implementation and co-ordination of...
- Dartmouth Dissertations
- The role of retinoic acid on CD4+ T cell biology.
- T cells.; Tretinoin -- Physiological effect. ; CD4-Positive T-Lymphocytes -- immunology.
- Dartmouth Dissertations
- 3D structure determination of reduced human glutaredoxin: Biophysical and biochemical characterization of CBFß proteins.
- Transcription factors. ; Glutaredoxin -- Structure. ; DNA-protein interactions.
- Dartmouth Dissertations
- On the leukemogenic mechanisms of core binding factor translocation products.
- Transcription factors -- Pathophysiology. Myeloid leukemia -- Genetic aspects. Genetic transcription -- Regulation.
- Core binding factor translocations and inversions are among the most frequently identified mutations in acute myeloid leukemia. We present work that characterizes the functional contributions of domains within the fusion proteins resulting from the...
- Dartmouth Dissertations
- Endogenous antitumor immunity elicited by adoptively transferred lymphocytes through CCL5 and CD40L signaling, and dendritic cell depletion.
- Ovaries -- Cancer -- Immunotherapy. T cells -- Therapeutic use. CD4 antigen -- Therapeutic use. Dendritic cells -- Therapeutic use. Chemokines -- Physiological effect. Cellular signal transduction.
- Adoptive cell transfer (ACT) is a promising therapy for various non-epithelial tumors but has not yet proven successful in ovarian cancer. Moreover, its effect upon endogenous antitumor immunity, and the contribution of CD4 + T cells, remain...
- Dartmouth Dissertations
- Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
- Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
- Dartmouth Dissertations
- The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
- Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
- Dartmouth Dissertations
- MLL1 plays an essential role in steady-state hematopoiesis and B Lymphopoiesis / by Tao Gan.
- The Mixed Lineage Leukemia (MLL1) gene was first cloned as a hot spot of chromosomal translocations in acute leukemia. More than 70 fusion proteins of MLL1 have been described in both lymphoid and myeloid leukemia and many are highly associated...
- Dartmouth Dissertations
- The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
- Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
- Dartmouth Dissertations
- Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
- Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
- Dartmouth Dissertations
- Structure and function of cytosolic glucocorticoid receptors in rodent lymphoid cells : studies in receptor stability, subunit composition, and phosphorylation
- Cell receptors; Glucocorticoids; Phosphorylation
- Dartmouth Dissertations
- Conformationally restricted bis(9-aminoacridine)s : a chemical and biological study
- Acridine.
- A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
- Dartmouth Dissertations
- Transcriptional regulation of the neuronal nACh receptor ?4 subunit gene.
- Nicotinic receptors -- Genetic aspects. Gene expression. Molecular genetics.
- Dartmouth Dissertations
- Reactive intermediates in chromium carcinogenesis.
- Chromium -- Toxicology. Carcinogenesis.
- Dartmouth Dissertations
- Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
- T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
- Dartmouth Dissertations
- Regulation of B lymphocyte proliferation and differentiation through CD40.
- B cells. CD antigens. Immune response -- Regulation.
- Dartmouth Dissertations
- Identification of steroid-binding and phosphorylated sites within the glucocorticoid receptor
- Glucocorticoids -- Receptors; Phosphorylation; Steroid-binding proteins
- Dartmouth Dissertations
- Dendritic cell Fcγ receptor expression and function
- Fc receptors. Dendritic cells. Immune recognition.
- Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
- Dartmouth Dissertations
- Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
- Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
- Dartmouth Dissertations
- Characterization of proteins that bind the conserved LVb and core sequences of mammalian type C retroviral enhancers.
- Proteins. Protein binding. Mouse leukemia viruses. Retroviruses.
- Dartmouth Dissertations
- Characterization of the monosaccharide transport system of the thioglycollate-elicited mouse peritoneal macrophage and in vitro actions of glucocorticoids on macrophage growth, glucose metabolism, and monosaccharide transport
- Glucose -- Metabolism. Macrophages. Glucocorticoids. Mice
- Dartmouth Dissertations
- The role of Estradiol in the regulation of the secretory immune system in the female reproductive tract.
- Estradiol. Generative organs Female -- Secretions. Generative organs
- Dartmouth Dissertations
- Synthetic studies of ellipticine alkaloids and structurally related compounds.
- Alkaloids -- Synthesis.
- Dartmouth Dissertations
- Electron paramagnetic resonance spectroscopy of chromium compounds.
- Chromium compounds. Electron paramagnetic resonance spectroscopy.
- Dartmouth Dissertations
- The occurrence of amino acid activating enzymes and transfer RNA in rat liver mitochondria.
- Mitochondria. Enzymes. ; Rats.
- Dartmouth Dissertations
- Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
- GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
- Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
- Dartmouth Dissertations
- The importance of dosage of core binding factors α and ß in hematopoietic development.
- Hematopoiesis -- Regulation. ; Transcription factors.
- Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
- Dartmouth Dissertations
- The immunobiology of antisecretory factor.
- Monoclonal antibodies. ; Immunoglobulins. ; Immune response -- Regulation. Intestines -- Secretions.
- Microglia are a bone marrow derived population of immune effector cells resident in the CNS. The function of these cells is manifold, and includes physiological, reparative, and immunological activities. During previous investigations of these...
- Dartmouth Dissertations
- Roles for protein phosphatases in cell survival and cell death pathways.
- Apoptosis. ; Phosphoprotein phosphatases -- Inhibitors. ; Cellular signal transduction. ; Genetic transcription -- Regulation.
- Apoptosis is important for tissue homeostasis and is the mechanism of cell death induced by many anticancer agents. The apoptotic machinery is present in all cells, such that tight regulation must exist to prevent untimely cell and tissue death. To...
- Dartmouth Dissertations
- The in vitro generation and long-term culture of tumor-specific cytotoxic T-lymphocytes
- Mouse leukemia viruses. ; Lymphocytes. ; T cells.
- Dartmouth Dissertations
- An analysis of the locomotive stimulant and the ECoG effects of L-DOPA.
- L-dihydroxphelylalanine. ; Amphetamines.
- Dartmouth Dissertations
- Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
- Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
- Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
- Dartmouth Dissertations
- Synthetic approaches to pyridocarbazoles via new indole and pyridine lithiaton methodology.
- Antineoplastic agents. ; Pyridocarbazoles.
- Dartmouth Dissertations

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