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Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.

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Author	Petryk, Alicia Ailie.
Title	Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy / by Alicia Ailie Petryk.
Date	2013
Abstract	Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical trials are being done using magnetic nanoparticle hyperthermia. The studies presented within this thesis examine several different aspects of the use of magnetic nanoparticles in hyperthermia therapies, particularly as an adjuvant treatment strategy with the chemotherapy cisplatinum. Magnetic nanoparticle (mNP) hyperthermia and microwave (915MHz) based hyperthermia were compared for treatment efficacy using induced murine flank tumors. Treatments were evaluated for normal tissue effects, cytotoxicity and resulting therapeutic ratio. In the case of the microwave comparison, mNPH demonstrated an improvement in treatment efficacy, although below statistical significance. However, there was less normal tissue damage with the mNP therapy. When examined as an adjuvant therapy with cisplatinum, it was determined that there is an enhancement of chemotherapy based therapeutic effect, when combined with magnetic nanoparticle hyperthermia. The importance of nanoparticle incubation, which results in changes in nanopartlcle distribution and cellular uptake, was also investigated. Optimization of nanoparticle distribution is essential for creating controlled and effective treatments. These studies indicated that when nanoparticles were allowed to incubate within the tumors of mice, the heating rate of the mNP was decreased. However, the tumor regrowth delay was similar to that seen with immediately activated nanoparticles. This was true both with and without cisplatinum adjuvant therapy. Systemically delivered nanoparticles for the treatment of metastatic cancer is also an attractive therapeutic approach. Cell pellets of different volumes were utilized to determine if cytotoxicity could be achieved with intracellular nanoparticles alone. Results indicate that a minimum number of cell
Description	xv, 134 leaves : ill. (some col.) 28 cm.
Format	application/pdf
Advisor	P. Jack Hoopes, Brian W. Pogue, Peter A. Kaufman, Alexander Hartov, John C. Bischof
College	Thayer School of Engineering.
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Copyright	All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means without permission in writing from the author.
DOI	http://dx.doi.org/10.1349/ddlp.1001

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