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Distinct neuroimmune interactions in acute inflammatory pain and persistent neuropathic pain.

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Call No.	QP451.4 .S94 2001
Author	Sweitzer, Sarah Marie
Title	Distinct neuroimmune interactions in acute inflammatory pain and persistent neuropathic pain.
Date	2001
Abstract	Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma, stroke, cancer, disease or in the absence of any apparent injury. This form of pain is resistant to current therapeutics, and thus the study of the cellular and molecular mechanisms that contribute to persistent neuropathic pain are of the utmost importance. The primary objective of this work was to test the hypothesis that central neuroimmune activation, characterized by glial activation and proinflammatory cytokine production, mediates the generation and maintenance of persistent neuropathic pain following peripheral nerve injury. Intraplantar zymosan was used to model acute inflammatory pain while selective lesion of the peripheral L5 spinal nerve was used to model persistent neuropathic pain. Utilization of pharmacological agents, immunohistochemistry, transgenic mice, chimeric rats and nociceptive behavioral tests demonstrated distinct cellular and molecular contributions to acute versus persistent pain. Acute inflammatory injury is characterized by self-resolving mild neuroimmune activation that may model beneficial physiological pain. Conversely, persistent nerve injury is characterized by intense and lasting neuroimmune activation accompanied by neuroinflammation that includes expression of immunoregulatory molecules on microglia as well as infiltration of macrophages and T lymphocytes into the lumbar spinal cord. Thus, chronic neuropathic pain involves both robust neuroinimune activation as well as neuroinflammation. Neuroinflammation is hypothesized to be responsible for the maintenance of pathological pain following peripheral nerve injury.
Description	1 online resource (xvi, 286 leaves) : illustrations (some color)
Format	application/pdf
Advisor	DeLeo, Joyce A.
Subject	Pain -- Immunological aspects. ; Inflammation -- Immunological aspects. ; Nervous system -- Diseases -- Immunological aspects. ; Neuroimmunology.
College	Dartmouth Medical School -- Department of Pharmacology and Toxicology.
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D)--Dartmouth College.
Copyright	In Copyright. This material is protected by copyright and/or related rights. You are free to use this material in any way that is permitted by copyright law that applies to your use. For other uses, you need to obtain permission from the rights-holder(s). http://rightsstatements.org/page/InC/1.0/
DOI	https://doi.org/10.1349/ddlp.2891

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