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MRI-coupled broadband near-infrared tomography for small animal brain studies.

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Call No.	Ph.D. 2005
Author	Xu, Heng, 1977-
Title	MRI-coupled broadband near-infrared tomography for small animal brain studies.
Date	2005
Abstract	Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and sensitivity. However, NIR imaging itself suffers poor spatial resolution due to the diffuse nature of NIR light in tissue. To improve the resolution and accuracy of the recovered physiological images, as well as being able to link the system into conventional imaging systems, one approach is to utilize more structural information from other available modalities such as MRI and another approach is to acquire more spectral information and utilize more wavelengths to achieve better quantification of chromophores. In this thesis, both approaches were implemented in a MRI-coupled broadband near-infrared tomography system, and several new developments in utilizing the NIR data are presented and analyzed. The system can measure complete attenuation spectra over the wavelength range 700-900nm using 8 transmit fibers and 8 separate receive fibers placed around the circumference of the rat head and is the first ever to provide NIR cross-sectional images of rat head with MRI data. Second derivative spectroscopy was used to estimate optical pathlengths at the water absorption features which allows the first ever reconstruction of both absorption and reduced scattering images using broadband NIR data. A novel reconstruction algorithm for multi-wavelength DOT is presented, which has the potential to dramatically reduce image artifacts often associated with unknown measurement errors. The in vivo performance of the system and the methods is examined by undertaking simultaneous BOLD MRI and NIR data collection during graded hypoxia in the rat brain.
Description	xiii, 195 leaves : ill. (some col.) 28 cm.
Format	application/pdf
Advisor	Brian W. Pogue.
Subject	Brain -- Tomography. Magnetic resonance imaging -- Brain. Near infrared spectroscopy. Image processing -- Digital techniques.
College	Thayer School of Engineering.
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Copyright	All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means without permission in writing from the author.
DOI	http://dx.doi.org/10.1349/ddlp.89

Title	Page 1
Format	application/pdf
Issuing Body	Dartmouth Dissertations are made available through the Dartmouth Digital Library.
Degree	Thesis (Ph.D.)--Dartmouth College.
Full Text	MRI-coupled Broadband Near-infrared Tomography for Small Animal Brain Studies A Thesis submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy by Heng Xu Thayer School of Engineering Dartmouth College Hanover, New Hampshire May 2005 Examining Committee ____________________________________ Brian W. Pogue, Ph. D., Chair ____________________________________ Jeffrey F. Dunn, Ph. D., Member ____________________________________ Hamid Dehghani, Ph. D., Member ____________________________________ Roger Springett, Ph. D., Member ____________________________________ David A. Boas, Ph. D., Member ____________________________________ Dean of Graduate Studies ____________________________________ (Signature of Author) ©2005 Trustees of Dartmouth College

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